A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+Foxp3+ T-Regulatory Cells.
IL-10
Icos
Mef2c
Mef2d
Treg
anti-cancer immunity
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
04
2021
accepted:
09
06
2021
entrez:
22
7
2021
pubmed:
23
7
2021
medline:
18
12
2021
Statut:
epublish
Résumé
The Mads/Mef2 (Mef2a/b/c/d) family of transcription factors (TFs) regulates differentiation of muscle cells, neurons and hematopoietic cells. By functioning in physiological feedback loops, Mef2 TFs promote the transcription of their repressor, Hdac9, thereby providing temporal control of Mef2-driven differentiation. Disruption of this feedback is associated with the development of various pathologic states, including cancer. Beside their direct involvement in oncogenesis, Mef2 TFs indirectly control tumor progression by regulating antitumor immunity. We recently reported that in CD4+CD25+Foxp3+ T-regulatory (Treg) cells, Mef2d is required for the acquisition of an effector Treg (eTreg) phenotype and for the activation of an epigenetic program that suppresses the anti-tumor immune responses of conventional T and B cells. We now report that as with Mef2d, the deletion of Mef2c in Tregs switches off the expression of
Identifiants
pubmed: 34290714
doi: 10.3389/fimmu.2021.703632
pmc: PMC8287581
doi:
Substances chimiques
MEF2 Transcription Factors
0
Mef2c protein, mouse
0
Mef2d protein, mouse
0
Repressor Proteins
0
Hdac9 protein, mouse
EC 3.5.1.98
Histone Deacetylases
EC 3.5.1.98
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
703632Subventions
Organisme : NIAID NIH HHS
ID : R01 AI123241
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA177852
Pays : United States
Informations de copyright
Copyright © 2021 Di Giorgio, Wang, Xiong, Christensen, Akimova, Han, Samanta, Trevisanut, Brancolini, Beier and Hancock.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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