Effects of Mild and Moderate Monoclonal Antibody Dose on Inflammation, Bone Loss, and Activation of the Central Nervous System in a Female Collagen Antibody-induced Arthritis Mouse Model.
Animals
Antibodies, Monoclonal
/ administration & dosage
Arthritis, Experimental
/ chemically induced
Arthritis, Rheumatoid
/ diagnosis
Bone Resorption
/ chemically induced
Cartilage, Articular
/ drug effects
Disease Models, Animal
Edema
/ chemically induced
Female
Forelimb
/ drug effects
Histocytochemistry
Lipopolysaccharides
/ administration & dosage
Mice
Mice, Inbred BALB C
Neuroglia
/ drug effects
Osteoclasts
/ drug effects
Periaqueductal Gray
/ drug effects
Severity of Illness Index
Spinal Cord
/ drug effects
bone
glial cells
inflammation
inflammatory arthritis
micro-computed tomography
osteoclast
Journal
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
ISSN: 1551-5044
Titre abrégé: J Histochem Cytochem
Pays: United States
ID NLM: 9815334
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
pubmed:
23
7
2021
medline:
3
8
2022
entrez:
22
7
2021
Statut:
ppublish
Résumé
Induction of severe inflammatory arthritis in the collagen antibody-induced arthritis (CAIA) murine model causes extensive joint damage and pain-like behavior compromising analysis. While mild models are less severe, their reduced, variable penetrance makes assessment of treatment efficacy difficult. This study aimed to compare macroscopic and microscopic changes in the paws, along with central nervous system activation between a mild and moderate CAIA model. Balb/c mice (
Identifiants
pubmed: 34291686
doi: 10.1369/00221554211033562
pmc: PMC8335846
doi:
Substances chimiques
Antibodies, Monoclonal
0
Lipopolysaccharides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
511-522Références
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