Slowing down as we age: aging of the cardiac pacemaker's neural control.
Autonomic control
Cardiac aging
Cardiac pacemaker
Heart rate
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
10
03
2021
accepted:
07
07
2021
pubmed:
23
7
2021
medline:
15
3
2022
entrez:
22
7
2021
Statut:
ppublish
Résumé
The cardiac pacemaker ignites and coordinates the contraction of the whole heart, uninterruptedly, throughout our entire life. Pacemaker rate is constantly tuned by the autonomous nervous system to maintain body homeostasis. Sympathetic and parasympathetic terminals act over the pacemaker cells as the accelerator and the brake pedals, increasing or reducing the firing rate of pacemaker cells to match physiological demands. Despite the remarkable reliability of this tissue, the pacemaker is not exempt from the detrimental effects of aging. Mammals experience a natural and continuous decrease in the pacemaker rate throughout the entire lifespan. Why the pacemaker rhythm slows with age is poorly understood. Neural control of the pacemaker is remodeled from birth to adulthood, with strong evidence of age-related dysfunction that leads to a downshift of the pacemaker. Such evidence includes remodeling of pacemaker tissue architecture, alterations in the innervation, changes in the sympathetic acceleration and the parasympathetic deceleration, and alterations in the responsiveness of pacemaker cells to adrenergic and cholinergic modulation. In this review, we revisit the main evidence on the neural control of the pacemaker at the tissue and cellular level and the effects of aging on shaping this neural control.
Identifiants
pubmed: 34292477
doi: 10.1007/s11357-021-00420-3
pii: 10.1007/s11357-021-00420-3
pmc: PMC8811107
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-17Subventions
Organisme : NIA NIH HHS
ID : R00 AG056595
Pays : United States
Informations de copyright
© 2021. The Author(s).
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