Cutaneous manifestations of chimeric antigen receptor T-cell therapy: An introduction for dermatologists.
CAR T
chimeric antigen receptor T-cell therapy
cutaneous reactions
immunotherapy
skin toxicity
Journal
Journal of the American Academy of Dermatology
ISSN: 1097-6787
Titre abrégé: J Am Acad Dermatol
Pays: United States
ID NLM: 7907132
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
12
05
2021
revised:
28
06
2021
accepted:
13
07
2021
pubmed:
23
7
2021
medline:
24
8
2022
entrez:
22
7
2021
Statut:
ppublish
Résumé
Chimeric antigen receptor T-cell therapy is an emerging immunotherapy with promising efficacy for the treatment of previously refractory or relapsed malignancies. As a personalized medicine approach, T cells are genetically engineered to express a receptor designed to bind a specific tumor antigen, leading to selective immune-mediated destruction of tumor cells. Due to the novelty of chimeric antigen receptor T-cell therapy, the safety profile continues to evolve with limited information currently available on cutaneous adverse events. Improved understanding of the spectrum of cutaneous adverse events may facilitate earlier recognition and appropriate management of these toxicities. To explore this knowledge gap, we discuss the available case reports and clinical trial results of cutaneous reactions associated with chimeric antigen receptor T-cell therapy.
Identifiants
pubmed: 34293386
pii: S0190-9622(21)02144-7
doi: 10.1016/j.jaad.2021.07.017
pii:
doi:
Substances chimiques
Receptors, Antigen, T-Cell
0
Receptors, Chimeric Antigen
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
597-604Informations de copyright
Copyright © 2021 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of interest None disclosed.