Upper Reference Limits for High-Sensitivity Cardiac Troponin T and N-Terminal Fragment of the Prohormone Brain Natriuretic Peptide in Patients With CKD.

Biomarkers Glomerular Filtration Rate Humans Natriuretic Peptide, Brain Peptide Fragments Renal Insufficiency, Chronic / epidemiology Troponin T
Cardiac biomarkers N-terminal pro–brain natriuretic peptide (NT-proBNP) cardiovascular disease chronic kidney disease (CKD) diagnostic threshold heart failure (HF) high-sensitivity cardiac troponin T (hsTnT) laboratory measurement myocardial infarction (MI) troponin upper limit of normal (ULN)

Journal

American journal of kidney diseases : the official journal of the National Kidney Foundation
ISSN: 1523-6838
Titre abrégé: Am J Kidney Dis
Pays: United States
ID NLM: 8110075

Informations de publication

Date de publication:
Mar 2022
Historique:
received: 28 12 2020
accepted: 03 06 2021
pubmed: 23 7 2021
medline: 8 4 2022
entrez: 22 7 2021
Statut: ppublish

Résumé

The utility of conventional upper reference limits (URL) for N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hsTnT) in chronic kidney disease (CKD) remains debated. We analyzed the distribution of hsTnT and NT-proBNP in people with CKD in ambulatory settings to examine the diagnostic value of conventional URL in this population. Observational study. We studied participants of the Chronic Renal Insufficiency Cohort (CRIC) with CKD and no self-reported history of cardiovascular disease. Estimated glomerular filtration rate (eGFR). NT-proBNP and hsTnT at baseline. We described the proportion of participants above the conventional URL for NT-proBNP (125pg/mL) and hsTnT (14ng/L) overall and by eGFR. We then estimated 99th percentile URL for NT-proBNP and hsTnT. Using quantile regression of the 99th percentile, we modeled the association of eGFR with NT-proBNP and hsTnT. Among 2,312 CKD participants, 40% and 43% had levels of NT-proBNP and hsTnT above the conventional URL, respectively. In those with eGFR <30mL/min/1.73m Study included ambulatory patients, and we could not test the accuracy of the URL of NT-proBNP and hsTnT in the acute care setting. In this ambulatory CKD population with no self-reported history of cardiovascular disease, a range of 40%-88% of participants had concentrations of NT-proBNP and hsTnT above the conventional URL, depending on eGFR strata. Developing eGFR-specific thresholds for these commonly used cardiac biomarkers in the setting of CKD may improve their utility for evaluation of suspected heart failure and myocardial infarction.

Identifiants

DOI: 10.1053/j.ajkd.2021.06.017 PMID: 34293394 PMC: PMC8766621
pubmed: 34293394
pii: S0272-6386(21)00760-5
doi: 10.1053/j.ajkd.2021.06.017
pmc: PMC8766621
mid: NIHMS1725815
pii:
doi:

Substances chimiques

Biomarkers 0
Peptide Fragments 0
Troponin T 0
Natriuretic Peptide, Brain 114471-18-0

Types de publication

Journal Article Observational Study Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

383-392

Subventions

Organisme : NCATS NIH HHS
ID : UL1 TR002548
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK060963
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024131
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK119199
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000003
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000439
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK060990
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR029879
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061028
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000433
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK060984
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061021
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK060990
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK060980
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061022
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK103612
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000424
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR016500
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM109036
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK060902
Pays : United States

Investigateurs

Lawrence J Appel (LJ)
Harold I Feldman (HI)
James P Lash (JP)
Robert G Nelson (RG)
Panduranga S Rao (PS)
Mahboob Rahman (M)
Vallabh O Shah (VO)
Raymond R Townsend (RR)
Mark L Unruh (ML)

Informations de copyright

Copyright © 2021 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Références

J Am Coll Cardiol. 2014 Apr 15;63(14):1441-8
pubmed: 24530665
N Engl J Med. 2009 Aug 27;361(9):858-67
pubmed: 19710484
Clin Chem. 2005 Nov;51(11):2059-66
pubmed: 16166165
Clin Chem. 1999 Jun;45(6 Pt 1):882-94
pubmed: 10351998
Nephrol Dial Transplant. 2008 Nov;23(11):3546-53
pubmed: 18562472
Clin Biochem. 2017 Jun;50(9):468-474
pubmed: 28193484
Curr Heart Fail Rep. 2018 Aug;15(4):239-249
pubmed: 29987498
J Am Coll Cardiol. 2006 Nov 7;48(9):1808-12
pubmed: 17084254
Am J Kidney Dis. 2011 Nov;58(5):717-28
pubmed: 21820220
J Am Coll Cardiol. 2013 Jan 15;61(2):187-95
pubmed: 23219305
Ann Intern Med. 2014 Oct 7;161(7):491-501
pubmed: 25111499
Clin J Am Soc Nephrol. 2015 Mar 6;10(3):515-29
pubmed: 25403922
Am J Kidney Dis. 2010 Dec;56(6):1082-94
pubmed: 21035932
Eur J Intern Med. 2011 Feb;22(1):108-11
pubmed: 21238905
Eur Heart J. 2012 Apr;33(8):988-97
pubmed: 22044927
Circulation. 2018 Jan 30;137(5):425-435
pubmed: 28978551
J Am Coll Cardiol. 2002 Jan 16;39(2):202-9
pubmed: 11788208
Clin J Am Soc Nephrol. 2009 Aug;4(8):1302-11
pubmed: 19541818
Am J Kidney Dis. 2018 Oct;72(4):519-528
pubmed: 29866459
Clin Chem. 2007 Apr;53(4):766-72
pubmed: 17332152
Circulation. 1991 Mar;83(3):902-12
pubmed: 1999039
J Am Heart Assoc. 2019 Aug 6;8(15):e012200
pubmed: 31379242
Coron Artery Dis. 2013 Dec;24(8):720-3
pubmed: 24128885
Ann Emerg Med. 2005 Jun;45(6):573-80
pubmed: 15940086
J Am Heart Assoc. 2019 Nov 5;8(21):e012336
pubmed: 31645163
J Am Soc Nephrol. 2003 Jul;14(7 Suppl 2):S148-53
pubmed: 12819321
N Engl J Med. 2004 Sep 23;351(13):1296-305
pubmed: 15385656
Ann Intern Med. 2014 Oct 7;161(7):502-12
pubmed: 25111593
J Am Coll Cardiol. 2009 Mar 10;53(10):884-90
pubmed: 19264247
Heart Fail Rev. 2014 Mar;19(2):267-84
pubmed: 23563622
Am Heart J. 2004 Jun;147(6):1078-84
pubmed: 15199359
Circulation. 2002 Jul 23;106(4):416-22
pubmed: 12135939
J Am Soc Nephrol. 2015 Apr;26(4):946-56
pubmed: 25278510
Clin Chem. 2012 Sep;58(9):1342-51
pubmed: 22791885
Clin Chem. 2007 Aug;53(8):1511-9
pubmed: 17586595
Ann Intern Med. 2009 May 5;150(9):604-12
pubmed: 19414839
Am J Nephrol. 2010;31(5):426-34
pubmed: 20389058
Clin Chem. 2018 Sep;64(9):1347-1360
pubmed: 29941469
J Am Coll Cardiol. 2006 Jan 3;47(1):91-7
pubmed: 16386670
Clin Biochem. 2015 Mar;48(4-5):247-53
pubmed: 25617663
Eur Heart J. 2008 Oct;29(19):2388-442
pubmed: 18799522
JAMA Cardiol. 2017 Mar 1;2(3):314-318
pubmed: 28002548
Am J Kidney Dis. 2003 Mar;41(3):571-9
pubmed: 12612980
Clin Chem. 2019 Nov;65(11):1448-1457
pubmed: 31578216
Evid Based Med. 2017 Dec;22(6):226
pubmed: 28924057
Circ Cardiovasc Interv. 2012 Apr;5(2):157-65
pubmed: 22354934
Am J Cardiol. 2008 Aug 15;102(4):469-74
pubmed: 18678308

Auteurs

Nisha Bansal (N)

Kidney Research Institute and Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington. Electronic address: nbansal@nephrology.washington.edu.

Leila R Zelnick (LR)

Kidney Research Institute and Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington.

Christie M Ballantyne (CM)

Center for Cardiometabolic Disease Prevention, Baylor College of Medicine, Houston, Texas.

Paulo H M Chaves (PHM)

Benjamin Leon Center for Geriatric Research and Education, Department of Translational Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida.

Robert H Christenson (RH)

Department of Pathology, School of Medicine, University of Maryland, Baltimore, Maryland.

Josef Coresh (J)

Department of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Christopher R deFilippi (CR)

Inova Center of Outcomes Research, Inova Heart and Vascular Institute, Falls Church, Virginia.

James A de Lemos (JA)

Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.

Lori B Daniels (LB)

Division of Cardiovascular Medicine, Department of Medicine, and Division of Epidemiology, Department of Family Medicine and Public Health, University of California San Diego, La Jolla, California.

Alan S Go (AS)

Division of Research, Kaiser Permanente Northern California, Oakland, California.

Jiang He (J)

Tulane University Translational Science Institute, Department of Epidemiology, School of Public Health & Tropical Medicine, Tulane University, New Orleans, Louisiana.

S Susan Hedayati (SS)

Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.

Kunihiro Matsushita (K)

Department of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Vijay Nambi (V)

Center for Cardiometabolic Disease Prevention, Baylor College of Medicine, Houston, Texas; Michael E. DeBakey Veterans Affairs Hospital, Houston, Texas.

Michael G Shlipak (MG)

Department of Medicine, and Department of Epidemiology and Biostatistics, University of California-San Francisco, and San Francisco VA Medical Center, San Francisco, California.

Jonathan J Taliercio (JJ)

Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio.

Stephen L Seliger (SL)

Division of Nephrology, School of Medicine, University of Maryland, Baltimore, Maryland.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Upper Reference Limits for High-Sensitivity...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques des voies urinaires › Débit de filtration glomérulaire › Upper Reference Limits for High-Sensitivity...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Upper Reference Limits for High-Sensitivity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Peptide natriurétique cérébral › Upper Reference Limits for High-Sensitivity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Fragments peptidiques › Upper Reference Limits for High-Sensitivity...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Insuffisance rénale chronique › Upper Reference Limits for High-Sensitivity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Troponine › Troponine T › Upper Reference Limits for High-Sensitivity...