Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Autophagic cell death
Curcumin
Mercury
Nuclear factor (erythroid-derived-2)-like 2 protein
Spleen
Journal
Ecotoxicology and environmental safety
ISSN: 1090-2414
Titre abrégé: Ecotoxicol Environ Saf
Pays: Netherlands
ID NLM: 7805381
Informations de publication
Date de publication:
01 Oct 2021
01 Oct 2021
Historique:
received:
31
03
2021
revised:
27
06
2021
accepted:
14
07
2021
pubmed:
23
7
2021
medline:
20
8
2021
entrez:
22
7
2021
Statut:
ppublish
Résumé
Mercury is a naturally occurring element and highly toxic to humans even at a low dosage. Curcumin is a polyphenol found in turmeric (Curcuma longa), widely used as a treatment strategy to improve antioxidant and anti-inflammatory properties. The purpose of this study was to investigate the potential protective mechanisms of curcumin in spleen damage induced by HgCl
Identifiants
pubmed: 34293585
pii: S0147-6513(21)00641-2
doi: 10.1016/j.ecoenv.2021.112529
pii:
doi:
Substances chimiques
NF-E2-Related Factor 2
0
Trace Elements
0
Phosphatidylinositol 3-Kinase
EC 2.7.1.137
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Mercury
FXS1BY2PGL
Curcumin
IT942ZTH98
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112529Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.