SARS-CoV-2 anti-spike antibody titres after vaccination with BNT162b2 in naïve and previously infected individuals.
BNT162b2
COVID-19
Healthcare workers
Vaccination
Journal
Journal of infection and public health
ISSN: 1876-035X
Titre abrégé: J Infect Public Health
Pays: England
ID NLM: 101487384
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
24
05
2021
revised:
03
07
2021
accepted:
07
07
2021
pubmed:
23
7
2021
medline:
4
8
2021
entrez:
22
7
2021
Statut:
ppublish
Résumé
Great expectations are placed in vaccines against COVID-19 to control the pandemic. We reviewed the antibody titres in a cohort of healthcare workers (HCWs) vaccinated with BNT162b2 to assess the influence of a previous infection on them. We stratified the results according to the individual history of nasopharyngeal swab (NPS) and symptoms. Among 3475 HCWs the highest titres were recorded among those infected more than 6 months before vaccination, independently of symptoms, followed by those infected less than 6 months before vaccination, especially in those with symptoms, and by uninfected HCWs. Vaccination with BNT162b2 can boost immunity acquired through infection, particularly in those infected more than 6 months before vaccination.
Identifiants
pubmed: 34293641
pii: S1876-0341(21)00192-1
doi: 10.1016/j.jiph.2021.07.005
pmc: PMC8285930
pii:
doi:
Substances chimiques
COVID-19 Vaccines
0
BNT162 Vaccine
N38TVC63NU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1120-1122Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Références
BMJ Open. 2021 Feb 22;11(2):e047216
pubmed: 33619203
Int J Obes (Lond). 2012 Aug;36(8):1072-7
pubmed: 22024641
N Engl J Med. 2021 Jul 1;385(1):90-92
pubmed: 33852796
Nat Med. 2021 Jun;27(6):981-984
pubmed: 33795870
PLoS One. 2021 Mar 24;16(3):e0245424
pubmed: 33760825
N Engl J Med. 2021 Apr 8;384(14):1372-1374
pubmed: 33691060
Clin Exp Immunol. 1982 Feb;47(2):467-73
pubmed: 7042142
Nat Commun. 2021 Jan 4;12(1):63
pubmed: 33397909
Front Immunol. 2021 Mar 12;12:657711
pubmed: 33777055
Lancet. 2021 Mar 20;397(10279):1057-1058
pubmed: 33640038
Cell Mol Immunol. 2021 Feb;18(2):318-327
pubmed: 33408342
Clin Microbiol Infect. 2020 Oct;26(10):1413.e9-1413.e13
pubmed: 32569835
N Engl J Med. 2021 Feb 11;384(6):533-540
pubmed: 33369366
Ann Am Thorac Soc. 2017 Nov;14(Supplement_5):S406-S409
pubmed: 29161078