Nail changes in diabetes.
Journal
Clinical and experimental dermatology
ISSN: 1365-2230
Titre abrégé: Clin Exp Dermatol
Pays: England
ID NLM: 7606847
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
accepted:
20
07
2021
pubmed:
23
7
2021
medline:
4
3
2022
entrez:
22
7
2021
Statut:
ppublish
Résumé
Diabetes is a common condition that is increasing in incidence worldwide. Although the skin manifestations of this condition are well described, there is scant literature on the associated nail changes. In this review, we describe the various clinical features of nail changes associated with diabetes, which can be broadly divided into infections, vascular changes, neuropathic manifestations and miscellaneous changes, although there is overlap between them. There is no pathognomonic nail alteration, but it is important for clinicians to be aware of the potential nail manifestations in diabetes as they can facilitate investigations and thereby early diagnosis of diabetes, resulting in holistic management of the patient.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
9-15Informations de copyright
© 2021 British Association of Dermatologists.
Références
Saeedi P, Petersohn I, Salpea P et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas. Diabetes Res Clin Pract 2019; 157: 107843.
Lima AL, Illing T, Schliemann S, Elsner P. Cutaneous manifestations of diabetes mellitus: a review. Am J Clin Dermatol 2017; 18: 541-53.
McGrath JA, Uitto J. Structure and function of the skin. In: Rook's Textbook of Dermatology, 9th edn (Griffiths CEM, Barker J, Bleiker T et al., eds). West Sussex, UK: John Wiley and Sons, 2016; 65.1-65.7.
Baswan S, Kasting GB, Li SK et al. Understanding the formidable nail barrier: a review of the nail microstructure, composition and diseases. Mycoses 2017; 60: 284-95. https://doi.org/10.1111/myc.12592
Yaemsiri S, Hou N, Slining MM, He K. Growth rate of human fingernails and toenails in healthy American young adults. J Eur Acad Dermatol Venereol 2010; 24: 420-3.
de Macedo GM, Nunes S, Barreto T. Skin disorders in diabetes mellitus: an epidemiology and physiopathology review. Diabetol Metab Syndr 2016; 8: 63.
Karadag AS, Ozlu E, Lavery MJ. Cutaneous manifestations of diabetes mellitus and the metabolic syndrome. Clin Dermatol 2018; 36: 89-93.
Kishabongo AS, Katchunga P, Van Aken EH et al. Glycation of nail proteins: from basic biochemical findings to a representative marker for diabetic glycation-associated target organ damage. PLoS One 2015; 10: e0120112.
Greene RA, Scher K. Nail changes associated with diabetes mellitus. J Am Acad Dermatol 1987; 16: 1015-21.
Hillson R. Fungi and diabetes. Pract Diab 2016; 33: 151-2. https://doi.org/10.1002/pdi.2024
Saunte D, Holgersen JB, Haedersdal M et al. Prevalence of toe nail onychomycosis in diabetic patients. Acta Derm Venereol 2006; 86: 425-8.
Gupta AK, Konnikov N, MacDonald P et al. Prevalence and epidemiology of toenail onychomycosis in diabetic subjects: a multicentre survey. Br J Dermatol 1998; 139: 665-71.
Alteras I, Saryt E. Prevalance of pathogenic fungi in the toenails of a diabetic patient. Mycopathologica 1979; 67: 157-9.
Boyko EJ, Ahroni JH, Cohen V et al. Prediction of diabetic foot ulcer occurrence using commonly available clinical information. The Seattle diabetic foot study. Diabetes Care 2006; 29: 1202-7.
Rich P. Special patient populations: onychomycosis in the diabetic patient. J Am Acad Dermatol 1996; 35: S10-12.
de Berker D. Nail anatomy. Clin Dermatol 2013; 31: 509-15.
UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998; 352: 837-53.
Maldonado G, Guerrero R, Paredes C, Rios C. Nailfold capillaroscopy in diabetes mellitus. Microvasc Res 2017; 112: 41-6.
Hosking SPM, Bhatia R, Crock PA et al. Non-invasive detection of microvascular changes in a paediatric and adolescent population with type 1 diabetes: a pilot cross-sectional study. BMC Endocr Disord 2013; 13: 14.
Chakrabarty A, Norman R, Phillips T. Cutaneous manifestations of diabetes. In: Diagnosis of Aging Skin Diseases (Norman R ed). London: Springer, 2008; 253-63.
Lithner F. Purpura, pigmentation and yellow nails of the lower extremities in diabetics. Acta Medica Scand 1976; 199: 203-8.
Mann RJ, Burton JL. Nail dystrophy due to diabetic neuropathy. Br Med J (Clin Res Ed) 1982; 284: 1445.
Witkowska AB, Jasterzbski TJ, Schwartz RA. Terry's nails: a sign of systemic disease. Indian J Dermatol 2017; 62: 309-11.
Masunaga M, Mizumoto J. Terry's nails due to uncontrolled diabetes mellitus. Am J Med 2021; 134: e428.
Vural S, Bostanci S, Koçyigit P et al. Risk factors and frequency of ingrown nails in adult diabetic patients. J Foot Ankle Surg 2018; 57: 289-95.
Kessinger A, Lemon HM, Foley JF. The glucagonoma syndrome and its management. J Surg Oncol 1977; 9: 419-24.
Grover C, Bansal S. The nail as an investigative tool in medicine; what a dermatologist ought to know. Ind J Dermatol Venereol Leprol 2017; 83: 635-43.
Oimomi M, Maeda Y, Hata F et al. Glycosylation levels of nail proteins in diabetic patients with retinopathy and neuropathy. Kobe J Med Sci 1985; 31: 183-8.
Vidyasagar P, Kumar BP. Toe nail changes in diabetes mellitus. IP Indian J Clin Exp Dermatol 2021; 7: 40-6.