Conservative oxygen therapy for critically ill patients: a meta-analysis of randomized controlled trials.
Conservative oxygen strategy
Critically ill
Meta-analysis
Mortality
Journal
Journal of intensive care
ISSN: 2052-0492
Titre abrégé: J Intensive Care
Pays: England
ID NLM: 101627304
Informations de publication
Date de publication:
22 Jul 2021
22 Jul 2021
Historique:
received:
04
05
2021
accepted:
12
07
2021
entrez:
23
7
2021
pubmed:
24
7
2021
medline:
24
7
2021
Statut:
epublish
Résumé
Conservative oxygen strategy is recommended in acute illness while its benefit in ICU patients remains controversial. Therefore, we sought to conduct a systematic review and meta-analysis to examine such oxygen strategies' effect and safety in ICU patients. We searched PubMed, Embase, and the Cochrane database from inception to Feb 15, 2021. Randomized controlled trials (RCTs) that compared a conservative oxygen strategy to a conventional strategy in critically ill patients were included. Results were expressed as mean difference (MD) and risk ratio (RR) with a 95% confidence interval (CI). The primary outcome was the longest follow-up mortality. Heterogeneity, sensitivity analysis, and publication bias were also investigated to test the robustness of the primary outcome. We included seven trials with a total of 5265 patients. In general, the conventional group had significantly higher SpO Our findings indicate that conservative oxygen therapy strategy did not improve the prognosis of the overall ICU patients. The subgroup of ICU patients with mild to moderate hypoxemia might obtain prognosis benefit from such a strategy without affecting other critical clinical results.
Identifiants
pubmed: 34294147
doi: 10.1186/s40560-021-00563-7
pii: 10.1186/s40560-021-00563-7
pmc: PMC8295978
doi:
Types de publication
Journal Article
Langues
eng
Pagination
47Informations de copyright
© 2021. The Author(s).
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