Serum Irisin May Predict Cardiovascular Events in Elderly Patients With Chronic Kidney Disease Stage 3-5.
Journal
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
ISSN: 1532-8503
Titre abrégé: J Ren Nutr
Pays: United States
ID NLM: 9112938
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
18
12
2020
revised:
06
04
2021
accepted:
25
05
2021
pubmed:
24
7
2021
medline:
4
5
2022
entrez:
23
7
2021
Statut:
ppublish
Résumé
Irisin is a circulating myokine released from skeletal muscles after physical exercise. Irisin production decreases during the course of chronic kidney disease (CKD) as a potential consequence of sarcopenia and physical inactivity. This observational study explored the relationship of serum irisin with cardiovascular outcome in 79 patients with stage 3-5 CKD. Serum irisin was significantly higher in healthy subjects (n = 20) than that in CKD patients (7 ± 2 vs. 3.1 ± 0.9 μg/mL; P = .0001) and was higher in patients with CKD stage 3 (3.2 ± 1 μg/mL) than in patients at stage 4 and 5 taken together (n = 36, 2.8 ± 0.7 μg/mL, P = .05). Patients in the lowest serum irisin tertile had lower serum 1,25(OH) These findings suggest that serum irisin may be a marker of cardiovascular outcome in patients with CKD.
Identifiants
pubmed: 34294556
pii: S1051-2276(21)00158-8
doi: 10.1053/j.jrn.2021.05.007
pii:
doi:
Substances chimiques
Fibronectins
0
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
282-291Informations de copyright
Copyright © 2021 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.