Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
22 07 2021
Historique:
received: 09 11 2020
accepted: 24 06 2021
entrez: 23 7 2021
pubmed: 24 7 2021
medline: 4 8 2021
Statut: epublish

Résumé

A comprehensive clinical and microbiological assessments of COVID-19 in front-line healthcare workers (HCWs) is needed. Between April 10th and May 28th, 2020, 319 HCWs with acute illness were reviewed. In addition to SARS-CoV-2 RT-PCR screening, a multiplex molecular panel was used for testing other respiratory pathogens. For SARS-CoV-2 positive HCWs, the normalized viral load, viral culture, and virus neutralization assays were performed weekly. For SARS-CoV-2 negative HCWs, SARS-CoV-2 serological testing was performed one month after inclusion. Among the 319 HCWs included, 67 (21.0%) were tested positive for SARS-CoV-2; 65/67 (97.0%) developed mild form of COVID-19. Other respiratory pathogens were found in 6/66 (9.1%) SARS-CoV-2 positive and 47/241 (19.5%) SARS-Cov-2 negative HCWs (p = 0.07). The proportion of HCWs with a viral load > 5.0 log

Identifiants

pubmed: 34294751
doi: 10.1038/s41598-021-93828-y
pii: 10.1038/s41598-021-93828-y
pmc: PMC8298657
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

14977

Investigateurs

Jerôme Adnot (J)
Dulce Alfaiate (D)
Alain Bergeret (A)
André Boibieux (A)
Florent Bonnet (F)
Florence Brunel-Dalmas (F)
Eurydice Caire (E)
Barbara Charbotel (B)
Pierre Chiarello (P)
Laurent Cotte (L)
Constance d'Aubarede (C)
François Durupt (F)
Vanessa Escuret (V)
Pascal Fascia (P)
Juliette Fontaine (J)
Lucie Gaillot-Durand (L)
Myriam Gillet (M)
Matthieu Godinot (M)
François Gueyffier (F)
Laurence Josset (L)
Matthieu Lahousse (M)
Hélène Lozano (H)
Djamila Makhloufi (D)
Marie-Paule Milon (MP)
Frédéric Moll (F)
David Narbey (D)
Julie-Anne Nazare (JA)
Fatima Oria (F)
Marielle Perry (M)
Virginie Pitiot (V)
Mélanie Prudent (M)
Muriel Rabilloud (M)
Audrey Samperiz (A)
Isabelle Schlienger (I)
Chantal Simon (C)
Martine Valette (M)

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2021. The Author(s).

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Auteurs

Antonin Bal (A)

Laboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.
CIRI, Centre International de Recherche en Infectiologie, Team VirPath, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007, Lyon, France.

Karen Brengel-Pesce (K)

Joint Research Unit Hospices Civils de Lyon-bioMérieux, Lyon Sud Hospital, Pierre-Bénite, France.

Alexandre Gaymard (A)

Laboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.
CIRI, Centre International de Recherche en Infectiologie, Team VirPath, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007, Lyon, France.

Grégory Quéromès (G)

CIRI, Centre International de Recherche en Infectiologie, Team VirPath, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007, Lyon, France.

Nicolas Guibert (N)

Université Claude Bernard Lyon1, Ifsttar, UMRESTTE, UMR T_9405, Lyon University, 8 Avenue Rockefeller, Lyon, France.
Occupational Health and Medicine Department, Hospices Civils de Lyon, Lyon, France.

Emilie Frobert (E)

Laboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.
CIRI, Centre International de Recherche en Infectiologie, Team VirPath, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007, Lyon, France.

Maude Bouscambert (M)

Laboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.
CIRI, Centre International de Recherche en Infectiologie, Team VirPath, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007, Lyon, France.

Mary-Anne Trabaud (MA)

Laboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.

Florence Allantaz-Frager (F)

Open Innovation and Partnerships (OIP), bioMérieux S.A., 69280, Marcy l'Etoile, France.

Guy Oriol (G)

Joint Research Unit Hospices Civils de Lyon-bioMérieux, Lyon Sud Hospital, Pierre-Bénite, France.

Valérie Cheynet (V)

Joint Research Unit Hospices Civils de Lyon-bioMérieux, Lyon Sud Hospital, Pierre-Bénite, France.

Constance d'Aubarede (C)

Université Claude Bernard Lyon1, Ifsttar, UMRESTTE, UMR T_9405, Lyon University, 8 Avenue Rockefeller, Lyon, France.
Occupational Health and Medicine Department, Hospices Civils de Lyon, Lyon, France.

Amélie Massardier-Pilonchery (A)

Université Claude Bernard Lyon1, Ifsttar, UMRESTTE, UMR T_9405, Lyon University, 8 Avenue Rockefeller, Lyon, France.
Occupational Health and Medicine Department, Hospices Civils de Lyon, Lyon, France.

Marlyse Buisson (M)

Institut de Biologie Structurale, CEA, CNRS and Centre Hospitalier Universitaire Grenoble Alpes, Université Grenoble Alpes, Grenoble, France.

Julien Lupo (J)

Institut de Biologie Structurale, CEA, CNRS and Centre Hospitalier Universitaire Grenoble Alpes, Université Grenoble Alpes, Grenoble, France.

Bruno Pozzetto (B)

GIMAP EA 3064 (Groupe Immunité des Muqueuses et Agents Pathogènes), Université Jean Monnet, Lyon University, Saint-Etienne, France.
Laboratory of Infectious Agents and Hygiene, University Hospital of Saint-Etienne, Saint-Etienne, France.

Pascal Poignard (P)

Institut de Biologie Structurale, CEA, CNRS and Centre Hospitalier Universitaire Grenoble Alpes, Université Grenoble Alpes, Grenoble, France.

Bruno Lina (B)

Laboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.
CIRI, Centre International de Recherche en Infectiologie, Team VirPath, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007, Lyon, France.

Jean-Baptiste Fassier (JB)

Université Claude Bernard Lyon1, Ifsttar, UMRESTTE, UMR T_9405, Lyon University, 8 Avenue Rockefeller, Lyon, France.
Occupational Health and Medicine Department, Hospices Civils de Lyon, Lyon, France.

Florence Morfin (F)

Laboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.
CIRI, Centre International de Recherche en Infectiologie, Team VirPath, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007, Lyon, France.

Sophie Trouillet-Assant (S)

CIRI, Centre International de Recherche en Infectiologie, Team VirPath, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007, Lyon, France. sophie.assant@chu-lyon.fr.
Joint Research Unit Hospices Civils de Lyon-bioMérieux, Lyon Sud Hospital, Pierre-Bénite, France. sophie.assant@chu-lyon.fr.

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