Neutrophils are important for the development of pro-reparative macrophages after irreversible electroporation of the liver in mice.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 07 2021
22 07 2021
Historique:
received:
22
04
2021
accepted:
22
06
2021
entrez:
23
7
2021
pubmed:
24
7
2021
medline:
10
11
2021
Statut:
epublish
Résumé
Irreversible electroporation (IRE) is a non-thermal tissue ablative technology that has emerging applications in surgical oncology and regenerative surgery. To advance its therapeutic usefulness, it is important to understand the mechanisms through which IRE induces cell death and the role of the innate immune system in mediating subsequent regenerative repair. Through intravital imaging of the liver in mice, we show that IRE produces distinctive tissue injury features, including delayed yet robust recruitment of neutrophils, consistent with programmed necrosis. IRE treatment converts the monocyte/macrophage balance from pro-inflammatory to pro-reparative populations, and depletion of neutrophils inhibits this conversion. Reduced generation of pro-reparative Ly6C
Identifiants
pubmed: 34294763
doi: 10.1038/s41598-021-94016-8
pii: 10.1038/s41598-021-94016-8
pmc: PMC8298444
doi:
Substances chimiques
Antigens, Ly
0
Ly-6C antigen, mouse
0
SOX9 Transcription Factor
0
Sox9 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14986Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK026743
Pays : United States
Organisme : NIBIB NIH HHS
ID : R21 EB024135
Pays : United States
Organisme : NIH/NIBIB
ID : R21-EB024135
Informations de copyright
© 2021. The Author(s).
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