Impaired SNF2L Chromatin Remodeling Prolongs Accessibility at Promoters Enriched for Fos/Jun Binding Sites and Delays Granule Neuron Differentiation.

ATAC-seq ISWI chromatin remodeler SMARCA1 Snf2L cerebellar granule neuron progenitors chromatin accessibility

Journal

Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914

Informations de publication

Date de publication:
2021
Historique:
received: 13 03 2021
accepted: 10 06 2021
entrez: 23 7 2021
pubmed: 24 7 2021
medline: 24 7 2021
Statut: epublish

Résumé

Chromatin remodeling proteins utilize the energy from ATP hydrolysis to mobilize nucleosomes often creating accessibility for transcription factors within gene regulatory elements. Aberrant chromatin remodeling has diverse effects on neuroprogenitor homeostasis altering progenitor competence, proliferation, survival, or cell fate. Previous work has shown that inactivation of the

Identifiants

pubmed: 34295220
doi: 10.3389/fnmol.2021.680280
pmc: PMC8290069
doi:

Types de publication

Journal Article

Langues

eng

Pagination

680280

Informations de copyright

Copyright © 2021 Goodwin, Zapata, Timpano, Marenger and Picketts.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Laura R Goodwin (LR)

Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.

Gerardo Zapata (G)

Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.

Sara Timpano (S)

Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Jacob Marenger (J)

Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

David J Picketts (DJ)

Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.

Classifications MeSH