Psychosocial stress and immunosuppression in cancer: what can we learn from new research?
Anxiety disorders
depressive disorders
epidemiology
neuroendocrinology
neuroimmunology
Journal
BJPsych advances
ISSN: 2056-4678
Titre abrégé: BJPsych Adv
Pays: England
ID NLM: 101654172
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
entrez:
23
7
2021
pubmed:
24
7
2021
medline:
24
7
2021
Statut:
ppublish
Résumé
It is generally believed that the physiological consequences of stress could contribute to poor outcomes for patients being treated for cancer. However, despite preclinical and clinical evidence suggesting that stress promotes increased cancer-related mortality, a comprehensive understanding of the mechanisms involved in mediating these effects does not yet exist. We reviewed 47 clinical studies published between 2007 and 2020 to determine whether psychosocial stress affects clinical outcomes in cancer: 6.4% of studies showed a protective effect; 44.6% showed a harmful effect; 48.9% showed no association. These data suggest that psychosocial stress could affect cancer incidence and/or mortality, but the association is unclear. To shed light on this potentially important relationship, objective biomarkers of stress are needed to more accurately evaluate levels of stress and its downstream effects. As a potential candidate, the neuroendocrine signalling pathways initiated by stress are known to affect anti-tumour immune cells, and here we summarise how this may promote an immunosuppressive, pro-tumour microenvironment. Further research must be done to understand the relationships between stress and immunity to more accurately measure how stress affects cancer progression and outcome.
Identifiants
pubmed: 34295535
doi: 10.1192/bja.2021.9
pmc: PMC8294471
mid: NIHMS1704137
doi:
Types de publication
Journal Article
Langues
eng
Pagination
187-197Subventions
Organisme : NCI NIH HHS
ID : P30 CA016056
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA205246
Pays : United States
Organisme : NCI NIH HHS
ID : F30 CA265127
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA085183
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA236390
Pays : United States
Déclaration de conflit d'intérêts
Declaration of interest None.
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