Regulation of cardiovascular biology by microsomal epoxide hydrolase.
Cancer
Cardiovascular
EPHX1
Epoxyeicosatrienoic acid
mEH
sEH
Journal
Toxicological research
ISSN: 1976-8257
Titre abrégé: Toxicol Res
Pays: Singapore
ID NLM: 101483324
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
23
12
2020
accepted:
06
01
2021
entrez:
23
7
2021
pubmed:
24
7
2021
medline:
24
7
2021
Statut:
epublish
Résumé
Microsomal epoxide hydrolase/epoxide hydrolase 1 (mEH/EPHX1) works in conjunction with cytochromes P450 to metabolize a variety of compounds, including xenobiotics, pharmaceuticals and endogenous lipids. mEH has been most widely studied for its role in metabolism of xenobiotic and pharmaceutical compounds where it converts hydrophobic and reactive epoxides to hydrophilic diols that are more readily excreted. Inhibition or genetic disruption of mEH can be deleterious in the face of many industrial, environmental or pharmaceutical exposures and
Identifiants
pubmed: 34295793
doi: 10.1007/s43188-021-00088-z
pii: 88
pmc: PMC8249505
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
285-292Subventions
Organisme : Intramural NIH HHS
ID : Z01 ES025034
Pays : United States
Informations de copyright
© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021.
Déclaration de conflit d'intérêts
Conflict of interestThe authors have no conflict of interest to disclose.
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