A Causal Role of Area hMST for Self-Motion Perception in Humans.
heading
medial-superior-temporal area
self-motion
transcranial magnetic stimulation
visually guided navigation
Journal
Cerebral cortex communications
ISSN: 2632-7376
Titre abrégé: Cereb Cortex Commun
Pays: United States
ID NLM: 101767128
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
05
2020
revised:
12
07
2020
accepted:
22
07
2020
entrez:
23
7
2021
pubmed:
24
7
2021
medline:
24
7
2021
Statut:
epublish
Résumé
Previous studies in the macaque monkey have provided clear causal evidence for an involvement of the medial-superior-temporal area (MST) in the perception of self-motion. These studies also revealed an overrepresentation of contraversive heading. Human imaging studies have identified a functional equivalent (hMST) of macaque area MST. Yet, causal evidence of hMST in heading perception is lacking. We employed neuronavigated transcranial magnetic stimulation (TMS) to test for such a causal relationship. We expected TMS over hMST to induce increased perceptual variance (i.e., impaired precision), while leaving mean heading perception (accuracy) unaffected. We presented 8 human participants with an optic flow stimulus simulating forward self-motion across a ground plane in one of 3 directions. Participants indicated perceived heading. In 57% of the trials, TMS pulses were applied, temporally centered on self-motion onset. TMS stimulation site was either right-hemisphere hMST, identified by a functional magnetic resonance imaging (fMRI) localizer, or a control-area, just outside the fMRI localizer activation. As predicted, TMS over area hMST, but not over the control-area, increased response variance of perceived heading as compared with noTMS stimulation trials. As hypothesized, this effect was strongest for contraversive self-motion. These data provide a first causal evidence for a critical role of hMST in visually guided navigation.
Identifiants
pubmed: 34296111
doi: 10.1093/texcom/tgaa042
pii: tgaa042
pmc: PMC8152865
doi:
Types de publication
Journal Article
Langues
eng
Pagination
tgaa042Informations de copyright
© The Author(s) 2020. Published by Oxford University Press.
Références
J Neurophysiol. 2012 Aug 1;108(3):794-801
pubmed: 22592304
Eur J Neurosci. 2008 May;27(10):2747-57
pubmed: 18547254
Seeing Perceiving. 2011;24(3):203-22
pubmed: 21864463
Nat Commun. 2019 Jun 14;10(1):2642
pubmed: 31201331
J Neurosci. 2013 Nov 13;33(46):18288-97
pubmed: 24227738
J Physiol. 2011 Feb 15;589(Pt 4):825-33
pubmed: 20679353
Cereb Cortex. 2017 Jan 1;27(1):1-10
pubmed: 28365777
J Neurophysiol. 2003 Aug;90(2):549-58
pubmed: 12750416
Behav Res Methods. 2009 Nov;41(4):1149-60
pubmed: 19897823
J Neurophysiol. 2000 Aug;84(2):730-43
pubmed: 10938300
Neuron. 2001 Jan;29(1):287-96
pubmed: 11182099
Trends Cogn Sci. 1999 Sep;3(9):329-336
pubmed: 10461195
PLoS One. 2012;7(12):e51383
pubmed: 23236490
J Neurosci. 2007 Sep 5;27(36):9742-56
pubmed: 17804635
Eur J Neurosci. 2002 Oct;16(8):1569-86
pubmed: 12405971
Vision Res. 2007 Mar;47(6):869-78
pubmed: 17178144
J Neurosci. 2010 Sep 29;30(39):13053-65
pubmed: 20881123
Front Hum Neurosci. 2016 Aug 17;10:415
pubmed: 27582701
J Neurophysiol. 2001 Oct;86(4):1991-2000
pubmed: 11600656
Electroencephalogr Clin Neurophysiol. 1994 Aug;91(2):79-92
pubmed: 7519144
Exp Brain Res. 2010 Jan;200(1):51-60
pubmed: 19727690
J Neurosci. 1996 Oct 1;16(19):6265-85
pubmed: 8815907
J Neurophysiol. 2007 Sep;98(3):1253-62
pubmed: 17634339
Brain Topogr. 2010 Jan;22(4):219-32
pubmed: 19862614
J Neurophysiol. 2017 Sep 1;118(3):1650-1663
pubmed: 28659463
Clin Neurophysiol. 2009 Dec;120(12):2008-2039
pubmed: 19833552
Nat Neurosci. 1998 May;1(1):59-63
pubmed: 10195110
Front Hum Neurosci. 2014 Sep 15;8:681
pubmed: 25309379
Annu Rev Neurosci. 2008;31:389-410
pubmed: 18558861
J Neurosci. 2011 Feb 16;31(7):2569-75
pubmed: 21325524
Front Behav Neurosci. 2013 Mar 05;7:15
pubmed: 23468002
J Neurosci. 1986 Jan;6(1):145-57
pubmed: 3944616
Eur J Neurosci. 2006 Jan;23(2):561-9
pubmed: 16420463
Eur J Neurosci. 2002 Nov;16(10):1877-86
pubmed: 12453051
Neuropsychologia. 2002;40(13):2280-7
pubmed: 12417458
Sci Rep. 2016 Dec 09;6:38919
pubmed: 27934947
Neuron. 2007 Jul 19;55(2):187-99
pubmed: 17640522
J Neurosci. 2002 Aug 15;22(16):7195-205
pubmed: 12177214
J Neurophysiol. 2009 Nov;102(5):2704-18
pubmed: 19587323
Neurosci Biobehav Rev. 2017 Dec;83:381-404
pubmed: 29032089
Behav Brain Res. 2019 Oct 17;372:112060
pubmed: 31251957
J Neurosci. 2011 Aug 17;31(33):12036-52
pubmed: 21849564
Brain Stimul. 2012 Apr;5(2):124-9
pubmed: 22494831
Neuroimage. 2013 Feb 15;67:89-100
pubmed: 23186916
Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):E3305-E3312
pubmed: 29555744
Curr Biol. 2008 Feb 12;18(3):191-4
pubmed: 18221876
J Neurophysiol. 2014 Nov 15;112(10):2470-80
pubmed: 25122709
J Neurosci. 2016 Mar 30;36(13):3789-98
pubmed: 27030763
Neuroimage. 2006 Feb 15;29(4):1326-35
pubmed: 16185899
J Neurosci. 2012 Feb 15;32(7):2299-313
pubmed: 22396405
J Neurosci. 2006 Jan 4;26(1):73-85
pubmed: 16399674
Cereb Cortex. 2010 Apr;20(4):759-72
pubmed: 19641017
Science. 1994 Apr 8;264(5156):231-7
pubmed: 8146653
Cereb Cortex. 2002 Jul;12(7):692-701
pubmed: 12050081
J Neurophysiol. 1991 Jun;65(6):1329-45
pubmed: 1875243
J Neurophysiol. 2018 Mar 1;119(3):1113-1126
pubmed: 29187554
Nat Neurosci. 2000 Dec;3(12):1322-8
pubmed: 11100154
J Neurophysiol. 2017 Jun 1;117(6):2209-2217
pubmed: 28298300
Neurosci Lett. 1996 May 31;210(2):83-6
pubmed: 8783278
Nat Commun. 2017 Oct 13;8(1):920
pubmed: 29030557
Neuropsychologia. 1999 Feb;37(2):169-79
pubmed: 10080374