Myelination of Callosal Axons Is Hampered by Early and Late Forelimb Amputation in Rats.
amputation
corpus callosum
morphological plasticity
myelination
somatosensory cortex
Journal
Cerebral cortex communications
ISSN: 2632-7376
Titre abrégé: Cereb Cortex Commun
Pays: United States
ID NLM: 101767128
Informations de publication
Date de publication:
2021
2021
Historique:
received:
17
11
2020
revised:
17
11
2020
accepted:
22
11
2020
entrez:
23
7
2021
pubmed:
24
7
2021
medline:
24
7
2021
Statut:
epublish
Résumé
Deafferentation is an important determinant of plastic changes in the CNS, which consists of a loss of inputs from the body periphery or from the CNS itself. Although cortical reorganization has been well documented, white matter plasticity was less explored. Our goal was to investigate microstructural interhemispheric connectivity changes in early and late amputated rats. For that purpose, we employed diffusion-weighted magnetic resonance imaging, as well as Western blotting, immunohistochemistry, and electron microscopy of sections of the white matter tracts to analyze the microstructural changes in the corticospinal tract and in the corpus callosum (CC) sector that contains somatosensory fibers integrating cortical areas representing the forelimbs and compare differences in rats undergoing forelimb amputation as neonates, with those amputated as adults. Results showed that early amputation induced decreased fractional anisotropy values and reduction of total myelin amount in the cerebral peduncle contralateral to the amputation. Both early and late forelimb amputations induced decreased myelination of callosal fibers. While early amputation affected myelination of thinner axons, late amputation disrupted axons of all calibers. Since the CC provides a modulation of inhibition and excitation between the hemispheres, we suggest that the demyelination observed among callosal fibers may misbalance this modulation.
Identifiants
pubmed: 34296146
doi: 10.1093/texcom/tgaa090
pii: tgaa090
pmc: PMC8152840
doi:
Types de publication
Journal Article
Langues
eng
Pagination
tgaa090Informations de copyright
© The Author(s) 2020. Published by Oxford University Press.
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