A case of gastric signet-ring cell carcinoma with a long-term retrospective follow-up of 17 years.
Early gastric cancer
Helicobacter pylori-negative
Natural history
Signet-ring cell carcinoma
Journal
Clinical journal of gastroenterology
ISSN: 1865-7265
Titre abrégé: Clin J Gastroenterol
Pays: Japan
ID NLM: 101477246
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
24
03
2021
accepted:
15
05
2021
pubmed:
24
7
2021
medline:
16
9
2021
entrez:
23
7
2021
Statut:
ppublish
Résumé
A man in his 60s underwent esophagogastroduodenoscopy (EGD) for gastric cancer screening in 2006. A pale, oval, depressed lesion, 8 mm in diameter, was seen in the greater curvature of the gastric antrum. The patient was followed up every 1-2 years. EGD performed 13 years after 2006 showed the lesion with an irregular margin. Histopathological diagnosis of a target biopsy was signet-ring cell carcinoma. The lesion was resected by endoscopic submucosal dissection. The resected specimen was 8 × 3 mm in size, and histopathological examination showed type 0-IIc, signet-ring cell carcinoma, pT1a, Ly0, V0, UL0, pHM0, pVM0. The patient had no history of Helicobacter pylori infection. The serum anti-H. pylori IgG antibody test result and the urea breath test result was negative. Histopathological examination did not reveal the presence of H. pylori. No evidence of atrophic gastritis on endoscopy was found. Based on these findings, the patient was confirmed as not having H. pylori infection. We retrospectively reviewed all previous endoscopic images and confirmed that the lesion was already present in the images taken 17 years ago. To our knowledge, this is the longest retrospective follow-up (17 years) of gastric signet-ring cell carcinoma remaining in the mucosa, without H. pylori infection.
Identifiants
pubmed: 34296396
doi: 10.1007/s12328-021-01443-1
pii: 10.1007/s12328-021-01443-1
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1337-1343Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021. Japanese Society of Gastroenterology.
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