Impact of asymptomatic
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Asymptomatic Infections
/ epidemiology
Child
Child, Preschool
Female
Humans
Infant
Kenya
/ epidemiology
Longitudinal Studies
Malaria, Falciparum
/ epidemiology
Male
Middle Aged
Plasmodium falciparum
/ physiology
Proportional Hazards Models
Sex Factors
Young Adult
asymptomatic infection
epidemiology
global health
infectious disease
malaria
microbiology
parasite density
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
23 07 2021
23 07 2021
Historique:
received:
26
03
2021
accepted:
20
07
2021
pubmed:
24
7
2021
medline:
21
10
2021
entrez:
23
7
2021
Statut:
epublish
Résumé
Asymptomatic In a 29-month cohort of 268 people in Western Kenya, we investigated the association between asymptomatic Compared to being uninfected, asymptomatic infections were associated with an increased 1 month likelihood of symptomatic malaria (adjusted hazard ratio [aHR]: 2.61, 95% CI: 2.05 to 3.33), and this association was modified by sex, with females (aHR: 3.71, 95% CI: 2.62 to 5.24) at higher risk for symptomaticity than males (aHR: 1.76, 95% CI: 1.24 to 2.50). This increased symptomatic malaria risk was observed for asymptomatic infections of all densities and in people of all ages. Long-term risk was attenuated but still present in children under age 5 (29-month aHR: 1.38, 95% CI: 1.05 to 1.81). In this high-transmission setting, asymptomatic This work was supported by the National Institute of Allergy and Infectious Diseases (R21AI126024 to WPO, R01AI146849 to WPO and SMT).
Sections du résumé
Background
Asymptomatic
Methods
In a 29-month cohort of 268 people in Western Kenya, we investigated the association between asymptomatic
Results
Compared to being uninfected, asymptomatic infections were associated with an increased 1 month likelihood of symptomatic malaria (adjusted hazard ratio [aHR]: 2.61, 95% CI: 2.05 to 3.33), and this association was modified by sex, with females (aHR: 3.71, 95% CI: 2.62 to 5.24) at higher risk for symptomaticity than males (aHR: 1.76, 95% CI: 1.24 to 2.50). This increased symptomatic malaria risk was observed for asymptomatic infections of all densities and in people of all ages. Long-term risk was attenuated but still present in children under age 5 (29-month aHR: 1.38, 95% CI: 1.05 to 1.81).
Conclusions
In this high-transmission setting, asymptomatic
Funding
This work was supported by the National Institute of Allergy and Infectious Diseases (R21AI126024 to WPO, R01AI146849 to WPO and SMT).
Identifiants
pubmed: 34296998
doi: 10.7554/eLife.68812
pii: 68812
pmc: PMC8337072
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI146849
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI126024
Pays : United States
Informations de copyright
© 2021, Sumner et al.
Déclaration de conflit d'intérêts
KS, JM, AO, EF, LA, SM, JE, BP, WP, ST No competing interests declared
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