The two faces of cyanide: an environmental toxin and a potential novel mammalian gasotransmitter.
bioenergetics
carbon monoxide
hydrogen sulfide
metabolism
mitochondria
nitric oxide
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
15
07
2021
received:
21
05
2021
accepted:
22
07
2021
pubmed:
24
7
2021
medline:
6
5
2022
entrez:
23
7
2021
Statut:
ppublish
Résumé
Cyanide is traditionally viewed as a cytotoxic agent, with its primary mode of action being the inhibition of mitochondrial Complex IV (cytochrome c oxidase). However, recent studies demonstrate that the effect of cyanide on Complex IV in various mammalian cells is biphasic: in lower concentrations (nanomolar to low micromolar) cyanide stimulates Complex IV activity, increases ATP production and accelerates cell proliferation, while at higher concentrations (high micromolar to low millimolar) it produces the previously known ('classic') toxic effects. The first part of the article describes the cytotoxic actions of cyanide in the context of environmental toxicology, and highlights pathophysiological conditions (e.g., cystic fibrosis with Pseudomonas colonization) where bacterially produced cyanide exerts deleterious effects to the host. The second part of the article summarizes the mammalian sources of cyanide production and overviews the emerging concept that mammalian cells may produce cyanide, in low concentrations, to serve biological regulatory roles. Cyanide fulfills many of the general criteria as a 'classical' mammalian gasotransmitter and shares some common features with the current members of this class: nitric oxide, carbon monoxide, and hydrogen sulfide.
Identifiants
pubmed: 34297873
doi: 10.1111/febs.16135
pmc: PMC9291117
doi:
Substances chimiques
Cyanides
0
Gasotransmitters
0
Electron Transport Complex IV
EC 1.9.3.1
Hydrogen Sulfide
YY9FVM7NSN
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2481-2515Informations de copyright
© 2021 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
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