Performance of the GHS Mixtures Equation for Predicting Acute Oral Toxicity.

Agrochemicals / toxicity Complex Mixtures / toxicity Detergents / toxicity Dose-Response Relationship, Drug Hazardous Substances Lethal Dose 50 Mouth Diseases / chemically induced Pesticides / toxicity Toxicity Tests, Acute / standards United Nations / standards
Acute systemic toxicity Alternative approaches GHS Mixtures equation Non-animal methods Regulatory requirements

Journal

Regulatory toxicology and pharmacology : RTP
ISSN: 1096-0295
Titre abrégé: Regul Toxicol Pharmacol
Pays: Netherlands
ID NLM: 8214983

Informations de publication

Date de publication:
Oct 2021
Historique:
received: 21 04 2021
revised: 01 07 2021
accepted: 13 07 2021
pubmed: 24 7 2021
medline: 8 1 2022
entrez: 23 7 2021
Statut: ppublish

Résumé

Acute oral toxicity classifications are based on the estimated chemical dose causing lethality in 50 % of laboratory animals tested (LD

Identifiants

DOI: 10.1016/j.yrtph.2021.105007 PMID: 34298086 PMC: PMC9623877
pubmed: 34298086
pii: S0273-2300(21)00148-3
doi: 10.1016/j.yrtph.2021.105007
pmc: PMC9623877
mid: NIHMS1726572
pii:
doi:

Substances chimiques

Agrochemicals 0
Complex Mixtures 0
Detergents 0
Hazardous Substances 0
Pesticides 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105007

Subventions

Organisme : NIEHS NIH HHS
ID : HHSN273201500010C
Pays : United States

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

Références

Regul Toxicol Pharmacol. 2018 Apr;94:183-196
pubmed: 29408321
ALTEX. 1999;16(3):129-134
pubmed: 11107319
Regul Toxicol Pharmacol. 2016 Dec;82:99-110
pubmed: 27765716
Toxicol In Vitro. 2017 Jun;41:245-259
pubmed: 28069485
Regul Toxicol Pharmacol. 2018 Feb;92:407-419
pubmed: 29305950
Toxicol Sci. 2022 Jun 28;188(1):34-47
pubmed: 35426934

Auteurs

Jon Hamm (J)

ILS, P.O. Box 13501, Research Triangle Park, NC, 27709, USA. Electronic address: jhamm@ils-inc.com.

David Allen (D)

ILS, P.O. Box 13501, Research Triangle Park, NC, 27709, USA. Electronic address: dallen@ils-inc.com.

Patricia Ceger (P)

ILS, P.O. Box 13501, Research Triangle Park, NC, 27709, USA. Electronic address: pceger1@ils-inc.com.

Tara Flint (T)

Office of Pesticide Programs, U.S. Environmental Protection Agency, 1200 Pennsylvania Ave, NW, Washington, DC, 20460, USA. Electronic address: Flint.Tara@epa.gov.

Anna Lowit (A)

Office of Pesticide Programs, U.S. Environmental Protection Agency, 1200 Pennsylvania Ave, NW, Washington, DC, 20460, USA. Electronic address: Lowit.Anna@epa.gov.

Lindsay O'Dell (L)

Office of Pesticide Programs, U.S. Environmental Protection Agency, 1200 Pennsylvania Ave, NW, Washington, DC, 20460, USA. Electronic address: Odell.Lindsay@epa.gov.

Jenny Tao (J)

Office of Pesticide Programs, U.S. Environmental Protection Agency, 1200 Pennsylvania Ave, NW, Washington, DC, 20460, USA. Electronic address: Tao.Jenny@epa.gov.

Nicole Kleinstreuer (N)

National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC, 27709, USA. Electronic address: nicole.kleinstreuer@nih.gov.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agrochimie › Performance of the GHS Mixtures Equation for...
questionsmedicales.fr › Mélanges complexes › Performance of the GHS Mixtures Equation for...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits domestiques › Détergents › Performance of the GHS Mixtures Equation for...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Performance of the GHS Mixtures Equation for...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Produits dangereux › Performance of the GHS Mixtures Equation for...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Dose létale 50 › Performance of the GHS Mixtures Equation for...
questionsmedicales.fr › Maladies du système stomatognathique › Maladies de la bouche › Performance of the GHS Mixtures Equation for...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Pesticides › Performance of the GHS Mixtures Equation for...
questionsmedicales.fr › Techniques d'investigation › Tests de toxicité › Tests de toxicité aigüe › Performance of the GHS Mixtures Equation for...
questionsmedicales.fr › Organisations et économie des soins de santé › Organismes › Agences internationales › Nations Unies › Performance of the GHS Mixtures Equation for...