Genomic Analysis of Response to Neoadjuvant Chemotherapy in Esophageal Adenocarcinoma.
NAV3
chemotherapy
esophageal adenocarcinoma
genomics
mutation
response
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
06 Jul 2021
06 Jul 2021
Historique:
received:
10
06
2021
revised:
28
06
2021
accepted:
01
07
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
25
7
2021
Statut:
epublish
Résumé
Neoadjuvant therapy followed by surgery is the standard of care for locally advanced esophageal adenocarcinoma (EAC). Unfortunately, response to neoadjuvant chemotherapy (NAC) is poor (20-37%), as is the overall survival benefit at five years (9%). The EAC genome is complex and heterogeneous between patients, and it is not yet understood whether specific mutational patterns may result in chemotherapy sensitivity or resistance. To identify associations between genomic events and response to NAC in EAC, a comparative genomic analysis was performed in 65 patients with extensive clinical and pathological annotation using whole-genome sequencing (WGS). We defined response using Mandard Tumor Regression Grade (TRG), with responders classified as TRG1-2 (
Identifiants
pubmed: 34298611
pii: cancers13143394
doi: 10.3390/cancers13143394
pmc: PMC8308111
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Cancer Research UK
ID : RG66287
Pays : United Kingdom
Organisme : Cancer Research UK
ID : RG81771/84119
Pays : United Kingdom
Organisme : Leukaemia UK
ID : 2016/JGF/0003
Organisme : NIHR Cambridge Biomedical Research Centre
ID : BRC-1215-20014
Organisme : Wessex Medical Research
ID : 2014 U10
Organisme : Medical Research Council
ID : RG84369
Pays : United Kingdom
Organisme : Southampton CRUK Centre Development Fund
ID : N/A
Organisme : Cancer Research UK
ID : A23924
Pays : United Kingdom
Organisme : Wessex Medical Research
ID : 2011 R06
Références
Gynecol Oncol. 2015 Apr;137(1):143-51
pubmed: 25579119
Genome Biol. 2011;12(4):R41
pubmed: 21527027
Clin Colorectal Cancer. 2018 Mar;17(1):e13-e19
pubmed: 28865674
Sci Adv. 2020 Feb 26;6(9):eaay4211
pubmed: 32133402
Nat Methods. 2016 Sep 29;13(10):806-7
pubmed: 27684579
Lancet Oncol. 2017 Sep;18(9):1249-1260
pubmed: 28784312
Nat Genet. 2019 Mar;51(3):506-516
pubmed: 30718927
Int J Cancer. 2021 Sep 15;149(6):1322-1331
pubmed: 34019698
Lancet. 2010 Aug 28;376(9742):687-97
pubmed: 20728210
Br J Cancer. 2018 Apr;118(8):1042-1050
pubmed: 29551775
Nat Genet. 2013 May;45(5):478-86
pubmed: 23525077
N Engl J Med. 2014 Dec 4;371(23):2189-2199
pubmed: 25409260
Science. 2015 Apr 3;348(6230):124-8
pubmed: 25765070
Science. 2015 Oct 9;350(6257):207-211
pubmed: 26359337
Springerplus. 2016 Apr 16;5:467
pubmed: 27119071
Lancet Oncol. 2017 Mar;18(3):357-370
pubmed: 28163000
Nat Rev Cancer. 2015 Mar;15(3):166-80
pubmed: 25709118
Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16910-5
pubmed: 20837533
Br J Cancer. 2012 Jan 31;106(3):517-24
pubmed: 22173670
Cancer Discov. 2015 Aug;5(8):821-831
pubmed: 26003801
Genome Res. 2018 Nov;28(11):1747-1756
pubmed: 30341162
J Clin Oncol. 2009 Oct 20;27(30):5062-7
pubmed: 19770374
Nat Protoc. 2015 Oct;10(10):1556-66
pubmed: 26379229
JAMA Oncol. 2017 Nov 1;3(11):1520-1528
pubmed: 28687830
JCO Precis Oncol. 2017 Jul;2017:
pubmed: 28890946
Genome Biol. 2016 Jun 06;17(1):122
pubmed: 27268795
J Thorac Dis. 2018 Aug;10(Suppl 21):S2565-S2573
pubmed: 30206500
Cancer Treat Rev. 2020 Jun;86:102024
pubmed: 32388292
Nat Rev Dis Primers. 2017 Jul 27;3:17048
pubmed: 28748917
BMC Cancer. 2011 Dec 07;11:509
pubmed: 22152101
Lancet Oncol. 2013 Jun;14(7):627-37
pubmed: 23623280
Nat Genet. 2016 Oct;48(10):1131-41
pubmed: 27595477
BMC Genomics. 2018 Aug 3;19(1):582
pubmed: 30075702
Clin Cancer Res. 2003 Oct 15;9(13):4819-25
pubmed: 14581353
Genes Chromosomes Cancer. 2013 Feb;52(2):191-201
pubmed: 23097141
Ann Oncol. 2011 Jun;22(6):1367-1373
pubmed: 21217058
Br J Surg. 2017 Dec;104(13):1816-1828
pubmed: 28944954
J Natl Cancer Inst. 2000 Aug 16;92(16):1316-21
pubmed: 10944553
Cancer Res. 2006 Apr 15;66(8):3992-5
pubmed: 16618717
Transl Oncol. 2018 Oct;11(5):1171-1187
pubmed: 30059832
Cell. 2016 Mar 24;165(1):35-44
pubmed: 26997480
Eur J Cancer. 2013 Sep;49(13):2823-31
pubmed: 23747051
BMC Bioinformatics. 2010 Jul 02;11:367
pubmed: 20598126
EMBO Mol Med. 2015 Feb 12;7(3):299-314
pubmed: 25678558
Nat Commun. 2018 Jul 30;9(1):2983
pubmed: 30061675
Lancet Oncol. 2011 Jul;12(7):681-92
pubmed: 21684205
Nat Commun. 2016 Apr 05;7:11111
pubmed: 27045317
Nat Genet. 2013 Oct;45(10):1127-33
pubmed: 24071851
Cancer Immunol Immunother. 2016 Jun;65(6):651-62
pubmed: 27020682
Gut. 2019 Nov;68(11):1918-1927
pubmed: 30852560
Eur J Surg Oncol. 1999 Aug;25(4):364-7
pubmed: 10419705
Int J Radiat Oncol Biol Phys. 2002 Feb 1;52(2):514-21
pubmed: 11872299
Nature. 2020 Feb;578(7793):94-101
pubmed: 32025018
J Thorac Dis. 2017 Jul;9(Suppl 8):S773-S780
pubmed: 28815073
Oncogenesis. 2020 Feb 6;9(2):12
pubmed: 32029709
Cancer Discov. 2016 Jul;6(7):740-53
pubmed: 27217383
Nat Commun. 2019 Jul 15;10(1):3101
pubmed: 31308377
Ann Oncol. 2017 May 1;28(5):1070-1077
pubmed: 28453704
Sci Rep. 2020 May 18;10(1):8188
pubmed: 32424219
Nature. 2017 Nov 23;551(7681):517-520
pubmed: 29132144
Genome Med. 2018 Nov 29;10(1):92
pubmed: 30497530
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Nat Commun. 2014 Oct 29;5:5224
pubmed: 25351503
N Engl J Med. 2009 Apr 2;360(14):1408-17
pubmed: 19339720
Genome Res. 2017 Jun;27(6):902-912
pubmed: 28465312
Oncol Rep. 2005 Dec;14(6):1453-9
pubmed: 16273238
Front Oncol. 2019 May 14;9:395
pubmed: 31192117
Nat Genet. 2006 Sep;38(9):1043-8
pubmed: 16921376
BMC Bioinformatics. 2019 May 22;20(1):264
pubmed: 31117948
Lancet Oncol. 2016 Dec;17(12):1697-1708
pubmed: 27776843
Cochrane Database Syst Rev. 2013 May 31;(5):CD008107
pubmed: 23728671
N Engl J Med. 2006 Jul 6;355(1):11-20
pubmed: 16822992
Cancer Discov. 2021 Feb;11(2):308-325
pubmed: 33234578
Ann Cardiothorac Surg. 2017 Mar;6(2):119-130
pubmed: 28447000
Hum Pathol. 1999 Sep;30(9):1087-92
pubmed: 10492044
Int J Cancer. 2010 Nov 1;127(9):2076-87
pubmed: 20473902
Clin Colorectal Cancer. 2019 Jun;18(2):102-109
pubmed: 30935775
Eur J Cancer. 2021 Mar;145:158-167
pubmed: 33485079
Oncotarget. 2017 Nov 1;8(59):100421-100432
pubmed: 29245989
Ann Oncol. 2018 Jun 1;29(6):1386-1393
pubmed: 29635438
J Cancer. 2015 Sep 15;6(11):1179-86
pubmed: 26516367
Bioinformatics. 2012 Jul 15;28(14):1811-7
pubmed: 22581179
Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6388-93
pubmed: 23547110
Lancet. 2002 May 18;359(9319):1727-33
pubmed: 12049861
Cancer. 1994 Jun 1;73(11):2680-6
pubmed: 8194005
Ann Oncol. 2014 Nov;25(11):2267-2271
pubmed: 25070544
Lancet. 2019 May 11;393(10184):1948-1957
pubmed: 30982686