Oncogenic Functions and Clinical Significance of Circular RNAs in Colorectal Cancer.
circRNAs
circular RNAs
colorectal cancer
oncogenic
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
06 Jul 2021
06 Jul 2021
Historique:
received:
17
05
2021
revised:
13
06
2021
accepted:
02
07
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
25
7
2021
Statut:
epublish
Résumé
Colorectal cancer (CRC) is ranked as the second most commonly diagnosed disease in females and the third in males worldwide. Therefore, the finding of new more reliable biomarkers for early diagnosis, for prediction of metastasis, and resistance to conventional therapies is an important challenge in overcoming the disease. The current review presents circular RNAs (circRNAs) with their unique features as potential prognostic and diagnostic biomarkers in CRC. The review highlights the mechanism of action and the role of circRNAs with oncogenic functions in the CRC as well as the association between their expression and clinicopathological characteristics of CRC patients. The comprehension of the role of oncogenic circRNAs in CRC pathogenesis is growing rapidly and the next step is using them as suitable new drug targets in the personalized treatment of CRC patients.
Identifiants
pubmed: 34298612
pii: cancers13143395
doi: 10.3390/cancers13143395
pmc: PMC8303601
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Bulgarian National Science Fund
ID : К∏-06-H23/6,18.12.2018
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