Methyltransferases in the Pathogenesis of Keratinocyte Cancers.
basal cell carcinoma
cutaneous squamous cell carcinoma
epigenetics
keratinocytes
methylation
skin cancer
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
07 Jul 2021
07 Jul 2021
Historique:
received:
09
06
2021
revised:
02
07
2021
accepted:
04
07
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
25
7
2021
Statut:
epublish
Résumé
Recent evidence suggests that the disruption of gene expression by alterations in DNA, RNA, and histone methylation may be critical contributors to the pathogenesis of keratinocyte cancers (KCs), made up of basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), which collectively outnumber all other human cancers combined. While it is clear that methylation modifiers are frequently dysregulated in KCs, the underlying molecular and mechanistic changes are only beginning to be understood. Intriguingly, it has recently emerged that there is extensive cross-talk amongst these distinct methylation processes. Here, we summarize and synthesize the latest findings in this space and highlight how these discoveries may uncover novel therapeutic approaches for these ubiquitous cancers.
Identifiants
pubmed: 34298617
pii: cancers13143402
doi: 10.3390/cancers13143402
pmc: PMC8304454
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NIAMS NIH HHS
ID : K08 AR070289
Pays : United States
Organisme : Dermatology Foundation
ID : Charles and Daneen Stiefel Award
Organisme : NIEHS NIH HHS
ID : P30 ES013508
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01AR077615
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR077615
Pays : United States
Organisme : Damon Runyon Cancer Research Foundation
ID : Clinical Investigator Award
Pays : United States
Organisme : NIAMS NIH HHS
ID : K08AR070289
Pays : United States
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