Micro- and Mycobiota Dysbiosis in Pancreatic Ductal Adenocarcinoma Development.
Malassezia
Proteobacteria
immunosuppression
inflammation
microbiome
mycobiome
pancreatic cancer
tumor initiation
tumor progression
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
08 Jul 2021
08 Jul 2021
Historique:
received:
23
05
2021
revised:
30
06
2021
accepted:
05
07
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
25
7
2021
Statut:
epublish
Résumé
Dysbiosis of the intestinal flora has emerged as an oncogenic contributor in different malignancies. Recent findings suggest a crucial tumor-promoting role of micro- and mycobiome alterations also in the development of pancreatic ductal adenocarcinoma (PDAC). To summarize the current knowledge about this topic, a systematic literature search of articles published until October 2020 was performed in MEDLINE (PubMed). An increasing number of publications describe associations between bacterial and fungal species and PDAC development. Despite the high inter-individual variability of the commensal flora, some studies identify specific microbial signatures in PDAC patients, including oral commensals like The presence of micro- and mycobial dysbiosis in pancreatic tumor tissue opens a fascinating perspective on PDAC oncogenesis. Further studies will pave the way for novel tumor markers and treatment strategies.
Sections du résumé
BACKGROUND
BACKGROUND
Dysbiosis of the intestinal flora has emerged as an oncogenic contributor in different malignancies. Recent findings suggest a crucial tumor-promoting role of micro- and mycobiome alterations also in the development of pancreatic ductal adenocarcinoma (PDAC).
METHODS
METHODS
To summarize the current knowledge about this topic, a systematic literature search of articles published until October 2020 was performed in MEDLINE (PubMed).
RESULTS
RESULTS
An increasing number of publications describe associations between bacterial and fungal species and PDAC development. Despite the high inter-individual variability of the commensal flora, some studies identify specific microbial signatures in PDAC patients, including oral commensals like
CONCLUSIONS
CONCLUSIONS
The presence of micro- and mycobial dysbiosis in pancreatic tumor tissue opens a fascinating perspective on PDAC oncogenesis. Further studies will pave the way for novel tumor markers and treatment strategies.
Identifiants
pubmed: 34298645
pii: cancers13143431
doi: 10.3390/cancers13143431
pmc: PMC8303110
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : In memoriam Dr. Gabriel Salzner Stiftung
ID : not applicable
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