Primary Central Nervous System Lymphoma in Elderly Patients: Management and Perspectives.
chemotherapy
elderly
immunotherapy
primary CNS lymphoma
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
12 Jul 2021
12 Jul 2021
Historique:
received:
01
05
2021
revised:
05
07
2021
accepted:
08
07
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
25
7
2021
Statut:
epublish
Résumé
The management of elderly patients suffering from primary central nervous system (CNS) lymphoma, who represent a rapidly growing population, is challenging. Despite the advances made in PCNSL treatment, the prognosis in older patients remains unsatisfactory. The high risk of systemic and CNS toxicity induced by a high-dose chemotherapy regimen and radiation therapy, respectively, limits the use of consolidation phase treatments in elderly patients and contributes to the poor outcome of these patients. Here, we review the current treatment strategies and ongoing trials proposed for elderly PCNSL patients.
Identifiants
pubmed: 34298693
pii: cancers13143479
doi: 10.3390/cancers13143479
pmc: PMC8303711
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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