Regulation and Functions of Protumoral Unconventional T Cells in Solid Tumors.
MAIT
NKT
cytokines
immunoregulation
protumor
solid cancer
tumor microenvironment
unconventional T cells
γδT
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
16 Jul 2021
16 Jul 2021
Historique:
received:
23
05
2021
revised:
02
07
2021
accepted:
12
07
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
25
7
2021
Statut:
epublish
Résumé
The vast majority of studies on T cell biology in tumor immunity have focused on peptide-reactive conventional T cells that are restricted to polymorphic major histocompatibility complex molecules. However, emerging evidence indicated that unconventional T cells, including γδ T cells, natural killer T (NKT) cells and mucosal-associated invariant T (MAIT) cells are also involved in tumor immunity. Unconventional T cells span the innate-adaptive continuum and possess the unique ability to rapidly react to nonpeptide antigens via their conserved T cell receptors (TCRs) and/or to activating cytokines to orchestrate many aspects of the immune response. Since unconventional T cell lineages comprise discrete functional subsets, they can mediate both anti- and protumoral activities. Here, we review the current understanding of the functions and regulatory mechanisms of protumoral unconventional T cell subsets in the tumor environment. We also discuss the therapeutic potential of these deleterious subsets in solid cancers and why further feasibility studies are warranted.
Identifiants
pubmed: 34298791
pii: cancers13143578
doi: 10.3390/cancers13143578
pmc: PMC8304984
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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