Drugs and Epigenetic Molecular Functions. A Pharmacological Data Scientometric Analysis.
computational knowledge-discovery
pharmacoepigenetics
pharmacological data science
pharmacological plasticity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Jul 2021
06 Jul 2021
Historique:
received:
15
05
2021
revised:
25
06
2021
accepted:
30
06
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
6
8
2021
Statut:
epublish
Résumé
Interactions of drugs with the classical epigenetic mechanism of DNA methylation or histone modification are increasingly being elucidated mechanistically and used to develop novel classes of epigenetic therapeutics. A data science approach is used to synthesize current knowledge on the pharmacological implications of epigenetic regulation of gene expression. Computer-aided knowledge discovery for epigenetic implications of current approved or investigational drugs was performed by querying information from multiple publicly available gold-standard sources to (i) identify enzymes involved in classical epigenetic processes, (ii) screen original biomedical scientific publications including bibliometric analyses, (iii) identify drugs that interact with epigenetic enzymes, including their additional non-epigenetic targets, and (iv) analyze computational functional genomics of drugs with epigenetic interactions. PubMed database search yielded 3051 hits on epigenetics and drugs, starting in 1992 and peaking in 2016. Annual citations increased to a plateau in 2000 and show a downward trend since 2008. Approved and investigational drugs in the DrugBank database included 122 compounds that interacted with 68 unique epigenetic enzymes. Additional molecular functions modulated by these drugs included other enzyme interactions, whereas modulation of ion channels or G-protein-coupled receptors were underrepresented. Epigenetic interactions included (i) drug-induced modulation of DNA methylation, (ii) drug-induced modulation of histone conformations, and (iii) epigenetic modulation of drug effects by interference with pharmacokinetics or pharmacodynamics. Interactions of epigenetic molecular functions and drugs are mutual. Recent research activities on the discovery and development of novel epigenetic therapeutics have passed successfully, whereas epigenetic effects of non-epigenetic drugs or epigenetically induced changes in the targets of common drugs have not yet received the necessary systematic attention in the context of pharmacological plasticity.
Identifiants
pubmed: 34298869
pii: ijms22147250
doi: 10.3390/ijms22147250
pmc: PMC8311652
pii:
doi:
Substances chimiques
Histones
0
Ion Channels
0
Pharmaceutical Preparations
0
Receptors, G-Protein-Coupled
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Acta Neurol Scand. 2003 Dec;108(6):443-4
pubmed: 14616298
Cancer Lett. 2009 Aug 8;280(2):201-10
pubmed: 19181442
Therapie. 2020 Apr;75(2):161-167
pubmed: 32164975
BMJ. 1995 Oct 21;311(7012):1047-52
pubmed: 7580659
Int J Biol Sci. 2018 Oct 20;14(13):1845-1858
pubmed: 30443188
Transl Psychiatry. 2014 Mar 04;4:e368
pubmed: 24594779
Haematologica. 2017 May;102(5):903-909
pubmed: 28126962
Stroke. 2018 Jan;49(1):54-61
pubmed: 29247141
World J Biol Psychiatry. 2014 May;15(4):334-45
pubmed: 24690014
Invest New Drugs. 2018 Aug;36(4):571-580
pubmed: 29504068
Mol Cell Biol. 2009 Apr;29(8):2278-95
pubmed: 19223465
Am Health Drug Benefits. 2016 Mar;9(Spec Feature):84-7
pubmed: 27668050
Clin Cancer Res. 2001 Apr;7(4):971-6
pubmed: 11309348
Bioinformatics. 2009 Jan 15;25(2):288-9
pubmed: 19033274
Genome Res. 2003 Apr;13(4):662-72
pubmed: 12654719
Blood Cancer J. 2011 Dec;1(12):e48
pubmed: 22829096
EBioMedicine. 2018 Nov;37:214-220
pubmed: 30389506
Genome Med. 2019 Dec 17;11(1):84
pubmed: 31847873
Nucleic Acids Res. 2001 Jan 1;29(1):308-11
pubmed: 11125122
Pharmacogenet Genomics. 2009 Jul;19(7):556-8
pubmed: 19512957
Expert Opin Investig Drugs. 2007 Jul;16(7):1111-20
pubmed: 17594194
Front Pharmacol. 2019 Aug 14;10:897
pubmed: 31474860
Nature. 2012 Dec 6;492(7427):108-12
pubmed: 23051747
J Neurotrauma. 2011 Feb;28(2):259-68
pubmed: 21175261
Biochem Biophys Res Commun. 1992 Mar 31;183(3):1184-90
pubmed: 1348932
Oncologist. 2007 Oct;12(10):1247-52
pubmed: 17962618
Heliyon. 2017 May 10;3(5):e00300
pubmed: 28560354
Cancer Chemother Pharmacol. 2015 Apr;75(4):869-74
pubmed: 25666183
Acta Pharm Sin B. 2015 Mar;5(2):106-12
pubmed: 26579435
Trends Pharmacol Sci. 2021 Apr;42(4):255-267
pubmed: 33563480
Pharmacol Res Perspect. 2019 Nov 21;7(6):e00532
pubmed: 31768257
Expert Rev Anticancer Ther. 2010 Jul;10(7):997-1008
pubmed: 20645688
Prostate. 2011 Mar 1;71(4):333-43
pubmed: 20809552
Nature. 2011 May 26;473(7348):478-83
pubmed: 21516106
J Med Genet. 2018 Jul;55(7):497-504
pubmed: 29574422
Expert Opin Investig Drugs. 2007 May;16(5):659-78
pubmed: 17461739
Epigenomics. 2016 Feb;8(2):167-79
pubmed: 26340303
Pain. 2009 Dec;146(3):231-232
pubmed: 19679395
Mol Cell Biochem. 2012 Jan;359(1-2):245-61
pubmed: 21842375
Cancer Immunol Immunother. 2018 Mar;67(3):381-392
pubmed: 29124315
Cancers (Basel). 2020 Mar 23;12(3):
pubmed: 32210076
Br J Pharmacol. 2013 Oct;170(3):581-91
pubmed: 23869687
Clin Epigenetics. 2019 Dec 11;11(1):190
pubmed: 31829238
Front Pharmacol. 2020 Dec 03;11:549191
pubmed: 33343343
PLoS One. 2015 Jun 10;10(6):e0129767
pubmed: 26061064
Nat Genet. 2000 May;25(1):25-9
pubmed: 10802651
Nucleic Acids Res. 2004 Jan 1;32(Database issue):D262-6
pubmed: 14681408
Nat Genet. 1999 Jan;21(1):103-7
pubmed: 9916800
Cell Res. 2011 Mar;21(3):381-95
pubmed: 21321607
Nucleic Acids Res. 2011 Jan;39(Database issue):D514-9
pubmed: 20929869
Proc Natl Acad Sci U S A. 2004 May 18;101(20):7499-504
pubmed: 15136719
Pharmacogenomics J. 2020 Jun;20(3):367-379
pubmed: 31819161
Mol Cancer Ther. 2006 Aug;5(8):1967-74
pubmed: 16928817
Life Sci. 2020 May 1;248:117469
pubmed: 32109485
PLoS One. 2014 Feb 25;9(2):e90191
pubmed: 24587272
J Biol Chem. 2014 Jul 25;289(30):20502-15
pubmed: 24895125
Orphanet J Rare Dis. 2015 May 07;10:55
pubmed: 25947946
Epigenetics. 2015;10(7):574-80
pubmed: 26023847
Lifestyle Genom. 2019;12(1-6):25-44
pubmed: 31546245
Trends Genet. 2016 Jul;32(7):444-455
pubmed: 27235113
Oncologist. 2018 May;23(5):631-636
pubmed: 29192015
PLoS One. 2020 Jul 10;15(7):e0235705
pubmed: 32649682
Dig Dis. 2011;29(2):130-5
pubmed: 21734376
Mol Pharmacol. 2006 Aug;70(2):487-92
pubmed: 16670375
Epigenomics. 2016 Dec;8(12):1583-1599
pubmed: 27685027
Cancer Prev Res (Phila). 2015 Aug;8(8):712-9
pubmed: 25968598
Nat Rev Genet. 2019 Apr;20(4):235-248
pubmed: 30647469
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3035-40
pubmed: 21300862
Transl Res. 2019 Jun;208:105-118
pubmed: 30904443
J Clin Res Pediatr Endocrinol. 2019 Apr 10;12(1):1-16
pubmed: 30968677
Rev Bras Ginecol Obstet. 2018 Dec;40(12):794-799
pubmed: 30536272
Bioinformatics. 2016 Sep 15;32(18):2847-9
pubmed: 27207943
Behav Brain Res. 2020 Jun 18;388:112627
pubmed: 32348868
Br J Cancer. 2012 Jan 3;106(1):77-84
pubmed: 22134508
CPT Pharmacometrics Syst Pharmacol. 2016 Apr;5(4):192-200
pubmed: 27069773
J Clin Oncol. 2012 Sep 20;30(27):3361-7
pubmed: 22915658
EMBO J. 2001 Dec 17;20(24):6969-78
pubmed: 11742974
Science. 1997 Sep 12;277(5332):1659-62
pubmed: 9287218
Br J Neurosurg. 2012 Jun;26(3):347-54
pubmed: 22168970
PLoS One. 2012;7(7):e40466
pubmed: 22808167
Anaesthesia. 1981 Dec;36(12):1129-32
pubmed: 6798892
Curr Opin Rheumatol. 2015 Jan;27(1):76-82
pubmed: 25415526
Pharmacogenomics. 2018 Jun 1;19(9):783-797
pubmed: 29792109
Drugs Today (Barc). 2007 Jun;43(6):395-422
pubmed: 17612710
Annu Rev Genet. 2018 Nov 23;52:21-41
pubmed: 30160987
Mol Psychiatry. 2015 May;20(5):621-31
pubmed: 25092246
Neuron. 2012 Feb 9;73(3):435-44
pubmed: 22325197
J Mol Neurosci. 2013 Feb;49(2):312-9
pubmed: 22684622
J Transl Med. 2006 Feb 28;4:10
pubmed: 16507100
Biosocieties. 2011 Jun;6(2):167-194
pubmed: 23227106
Nucleic Acids Res. 1999 Jan 1;27(1):29-34
pubmed: 9847135
Drugs. 2018 Jun;78(9):959-963
pubmed: 29869203
Nat Neurosci. 2004 Aug;7(8):847-54
pubmed: 15220929
Am J Psychiatry. 2014 Aug;171(8):872-880
pubmed: 24832930
Nat Rev Neurosci. 2011 Oct 12;12(11):623-37
pubmed: 21989194
Biomark Insights. 2019 May 08;14:1177271919846454
pubmed: 31105426
Pain. 2013 Jan;154(1):15-23
pubmed: 23273101
EMBO J. 2003 Jul 1;22(13):3411-20
pubmed: 12840003
Arthritis Rheum. 2011 May;63(5):1452-8
pubmed: 21538322
Carcinogenesis. 2004 Oct;25(10):1917-23
pubmed: 15205357
BMC Med Genomics. 2009 Nov 30;2:67
pubmed: 19948057
J Med Chem. 1995 Apr 14;38(8):1411-3
pubmed: 7731025
J Neurosci. 2012 Nov 28;32(48):17454-64
pubmed: 23197736
Br J Haematol. 2010 May;149(4):518-28
pubmed: 20201941
Br J Haematol. 2010 Aug;150(4):446-55
pubmed: 20560970
Drugs Today (Barc). 2020 Jun;56(6):377-387
pubmed: 32525136
Epilepsia. 1975 Nov;16(4):549-73
pubmed: 812693
Sci Transl Med. 2011 Nov 2;3(107):107ra109
pubmed: 22049069
Lancet Neurol. 2016 Feb;15(2):141
pubmed: 28463122
Front Mol Neurosci. 2017 Aug 08;10:252
pubmed: 28848388
Nucleic Acids Res. 2021 Jan 8;49(D1):D480-D489
pubmed: 33237286
Clin Cancer Res. 2009 Jun 15;15(12):3938-46
pubmed: 19509174
PLoS One. 2010 Nov 19;5(11):e14060
pubmed: 21124914
Hum Mol Genet. 2012 Nov 1;21(21):4751-60
pubmed: 22875838
ChemMedChem. 2009 May;4(5):792-9
pubmed: 19322801
Oncogene. 2002 Aug 12;21(35):5427-40
pubmed: 12154405
Curr Opin HIV AIDS. 2013 May;8(3):230-5
pubmed: 23446138
Trends Mol Med. 2013 Dec;19(12):742-53
pubmed: 24054876
Syst Rev. 2018 Sep 27;7(1):147
pubmed: 30261915
Sci Rep. 2019 Nov 14;9(1):16862
pubmed: 31727944
Eur Rev Med Pharmacol Sci. 2020 Jul;24(13):7412-7419
pubmed: 32706080
Int J Neuropsychopharmacol. 2012 Jun;15(5):669-79
pubmed: 21682946
Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082
pubmed: 29126136
Front Genet. 2020 Jun 30;11:654
pubmed: 32695141
Clin Cancer Res. 2017 Jul 1;23(13):3307-3315
pubmed: 28053023
Clin Epigenetics. 2020 Sep 14;12(1):139
pubmed: 32928291
Neurosci Biobehav Rev. 2015 Aug;55:520-35
pubmed: 26073068
PLoS One. 2012;7(6):e39917
pubmed: 22761927
Drugs Today (Barc). 2007 Sep;43(9):585-99
pubmed: 17940636
Cancer Res. 2007 Feb 1;67(3):876-80
pubmed: 17283117
PLoS One. 2014 Jan 22;9(1):e86787
pubmed: 24466240
Genes (Basel). 2020 Oct 30;11(11):
pubmed: 33143137
Blood Cancer J. 2015 May 15;5:e313
pubmed: 25978433
Clin Epigenetics. 2015 Nov 14;7:123
pubmed: 26583054
BJPsych Bull. 2020 Apr;44(2):81-83
pubmed: 33858525