Does the Interaction between Local and Systemic Inflammation Provide a Link from Psychology and Lifestyle to Tissue Health in Musculoskeletal Conditions?
fibrosis
lifestyle factors
local inflammation
psychological factors
systemic inflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Jul 2021
07 Jul 2021
Historique:
received:
31
05
2021
revised:
02
07
2021
accepted:
04
07
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
4
8
2021
Statut:
epublish
Résumé
Musculoskeletal conditions are known to involve biological, psychological, social and, often, lifestyle elements. However, these domains are generally considered in isolation from each other. This siloed approach is unlikely to be adequate to understand the complexity of these conditions and likely explains a major component of the disappointing effects of treatment. This paper presents a hypothesis that aims to provide a foundation to understand the interaction and integration between these domains. We propose a hypothesis that provides a plausible link between psychology and lifestyle factors with tissue level effects (such as connective tissue dysregulation/accumulation) in musculoskeletal conditions that is founded on understanding the molecular basis for interaction between systemic and local inflammation. The hypothesis provides plausible and testable links between mind and body, for which empirical evidence can be found for many aspects. We present this hypothesis from the perspective of connective tissue biology and pathology (fibrosis), the role of inflammation locally (tissue level), and how this inflammation is shaped by systemic inflammation through bidirectional pathways, and various psychological and lifestyle factors via their influence on systemic inflammation. This hypothesis provides a foundation for new consideration of the development and refinement of personalized multidimensional treatments for individuals with musculoskeletal conditions.
Identifiants
pubmed: 34298917
pii: ijms22147299
doi: 10.3390/ijms22147299
pmc: PMC8304860
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR056019
Pays : United States
Organisme : National Health and Medical Research Council NHMRC of Australia
ID : Project Grant: ID631369; Program Grant: APP1091302; PWH supported by NHMRC Fellowship APP1194937
Organisme : U.S. Department of Defense
ID : Grant ID: W81XWH2010909
Références
J Cachexia Sarcopenia Muscle. 2017 Feb;8(1):131-144
pubmed: 27897392
Muscle Nerve. 2011 Sep;44(3):318-31
pubmed: 21949456
Exp Cell Res. 2008 Aug 1;314(13):2334-51
pubmed: 18555216
Diabetes. 2005 Oct;54(10):2939-45
pubmed: 16186396
Mediators Inflamm. 2015;2015:816460
pubmed: 26089604
Psychol Bull. 2004 Jul;130(4):601-30
pubmed: 15250815
J Orthop Res. 2008 Oct;26(10):1320-6
pubmed: 18464247
FASEB J. 2017 Sep;31(9):3719-3728
pubmed: 28507168
Pain. 2008 Nov 15;140(1):135-144
pubmed: 18778895
Hum Factors. 2014 Aug;56(5):864-72
pubmed: 25141594
Respir Res. 2018 Jan 18;19(1):14
pubmed: 29347981
J Neuroinflammation. 2015 Jun 06;12:114
pubmed: 26048578
Cell Tissue Res. 2016 Jun;364(3):647-660
pubmed: 26742767
J Clin Invest. 2012 Dec;122(12):4519-32
pubmed: 23143303
Am J Epidemiol. 2001 Feb 1;153(3):242-50
pubmed: 11157411
Bone. 2015 Nov;80:115-125
pubmed: 26453501
Occup Environ Med. 2005 Jun;62(6):363-7
pubmed: 15901882
Neuroscience. 2013 Aug 29;246:199-229
pubmed: 23644052
Arthritis Rheum. 2009 Aug 15;61(8):1018-24
pubmed: 19644894
Eur J Transl Myol. 2019 Feb 28;29(1):8060
pubmed: 31019664
Curr Pain Headache Rep. 2007 Apr;11(2):98-103
pubmed: 17367587
J Psychopharmacol. 2006 Jul;20(4 Suppl):79-84
pubmed: 16785275
Regen Med Res. 2013 Oct 01;1(1):2
pubmed: 25984321
Am J Physiol Regul Integr Comp Physiol. 2002 Sep;283(3):R698-709
pubmed: 12185005
Alcohol Clin Exp Res. 2014 Nov;38(11):2697-706
pubmed: 25421506
Neuroimmunomodulation. 2006;13(5-6):277-82
pubmed: 17709949
Muscle Nerve. 2003 Oct;28(4):449-59
pubmed: 14506717
Nat Rev Neurosci. 2009 Jun;10(6):397-409
pubmed: 19469025
J Neuroimmune Pharmacol. 2010 Mar;5(1):83-91
pubmed: 20020329
Exp Ther Med. 2017 Apr;13(4):1209-1214
pubmed: 28413459
Front Physiol. 2019 Jan 30;10:42
pubmed: 30761018
Eur Respir J. 2006 Jan;27(1):51-9
pubmed: 16387935
Fibrogenesis Tissue Repair. 2012 Jun 06;5(Suppl 1):S24
pubmed: 23259531
Arthritis Rheum. 2006 Feb;54(2):682; author reply 682-3
pubmed: 16447248
Clin Transl Gastroenterol. 2019 Jun;10(6):e00052
pubmed: 31211759
PLoS One. 2013 Aug 28;8(8):e71875
pubmed: 24015193
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Apr 29;35(3):744-59
pubmed: 20828592
Connect Tissue Res. 2021 Jan;62(1):133-149
pubmed: 33030055
J Pharm Bioallied Sci. 2011 Jan;3(1):118-27
pubmed: 21430962
Exerc Immunol Rev. 2004;10:66-74
pubmed: 15633587
J Immunol. 2010 Jan 15;184(2):540-4
pubmed: 20018617
Ann N Y Acad Sci. 2004 Dec;1032:141-53
pubmed: 15677401
Int J Mol Sci. 2020 Dec 04;21(23):
pubmed: 33291708
Biochim Biophys Acta. 2013 Jul;1832(7):989-97
pubmed: 23246690
Cytokine. 2011 Nov;56(2):318-24
pubmed: 21737301
Brain Behav Immun. 2007 Aug;21(6):727-35
pubmed: 17604598
Mediators Inflamm. 2013;2013:540370
pubmed: 24302815
Scand J Med Sci Sports. 2007 Oct;17(5):580-7
pubmed: 17076827
FASEB J. 2003 May;17(8):884-6
pubmed: 12626436
J Orthop Res. 2017 Dec;35(12):2700-2706
pubmed: 28480978
Physiol Rev. 2019 Jul 1;99(3):1325-1380
pubmed: 30920354
J Anat. 2006 Apr;208(4):459-70
pubmed: 16637872
BMJ. 2014 Feb 13;348:g1151
pubmed: 24524926
Am J Phys Med Rehabil. 2009 Jun;88(6):502-22
pubmed: 19454857
Am J Lifestyle Med. 2007 May;1(3):220-235
pubmed: 25431545
PLoS One. 2012;7(5):e38359
pubmed: 22675458
Oxid Med Cell Longev. 2019 Mar 26;2019:2484678
pubmed: 31049128
Biol Psychiatry. 2016 Jul 1;80(1):40-52
pubmed: 26140821
Spine (Phila Pa 1976). 1994 Jan 15;19(2):165-72
pubmed: 8153825
Br J Sports Med. 2018 Dec;52(23):1497
pubmed: 30072398
Cell Tissue Res. 2018 Mar;371(3):531-539
pubmed: 29383445
J Pathol. 2013 Jan;229(2):298-309
pubmed: 22996908
J Orthop Res. 2017 Jul;35(7):1539-1547
pubmed: 27505847
FASEB J. 2020 May;34(5):6554-6569
pubmed: 32227398
J Bone Miner Res. 2011 Aug;26(8):1891-903
pubmed: 21509823
Alcohol Clin Exp Res. 2006 Apr;30(4):720-30
pubmed: 16573591
Am J Psychiatry. 2003 Sep;160(9):1554-65
pubmed: 12944327
J Intern Med. 2005 Feb;257(2):139-55
pubmed: 15656873
Aust N Z J Psychiatry. 2019 Aug;53(8):742-759
pubmed: 30864461
J Cell Physiol. 2008 May;215(2):410-21
pubmed: 18064627
World J Gastroenterol. 2007 Oct 7;13(37):4974-8
pubmed: 17854140
Psychol Bull. 2014 May;140(3):774-815
pubmed: 24417575
Obes Rev. 2003 Nov;4(4):257-90
pubmed: 14649376
Int J Inflam. 2011;2011:529061
pubmed: 21837268
Spine (Phila Pa 1976). 2015 Jul 15;40(14):1057-71
pubmed: 25943090
Alcohol Clin Exp Res. 2008 Jan;32(1):138-47
pubmed: 18028526
J Cell Commun Signal. 2021 Sep;15(3):317-334
pubmed: 33689121
JAMA Psychiatry. 2020 Oct 1;77(10):1031-1043
pubmed: 32492090
World J Gastroenterol. 2014 Oct 28;20(40):14660-71
pubmed: 25356029
Clin J Pain. 2008 Mar-Apr;24(3):273-8
pubmed: 18287835
Eur Respir J. 2004 Mar;23(3):464-76
pubmed: 15065840
Eur Cardiol. 2019 Apr;14(1):50-59
pubmed: 31131037
Brain Behav Immun. 2007 Nov;21(8):1050-7
pubmed: 17524614
Best Pract Res Clin Endocrinol Metab. 2010 Oct;24(5):775-84
pubmed: 21112025
Obes Rev. 2019 Nov;20(11):1572-1596
pubmed: 31410961
J Physiol. 1999 Feb 15;515 ( Pt 1):287-91
pubmed: 9925898
Mol Pain. 2008 Oct 28;4:49
pubmed: 18957097
J Biol Chem. 2018 Nov 16;293(46):17953-17970
pubmed: 30262666
Front Psychiatry. 2015 Apr 30;6:59
pubmed: 25983695
J Pain. 2018 Oct;19(10):1147-1156
pubmed: 29715519
Brain Behav Immun. 2015 May;46:319-26
pubmed: 25733101
Exerc Immunol Rev. 2006;12:6-33
pubmed: 17201070
BMC Musculoskelet Disord. 2021 May 5;22(1):417
pubmed: 33952219
Br J Nutr. 2015 Oct 14;114(7):999-1012
pubmed: 26228057
Sci Rep. 2020 Jan 20;10(1):694
pubmed: 31959927
J Clin Endocrinol Metab. 2000 Oct;85(10):3597-603
pubmed: 11061508
Adv Exp Med Biol. 1999;461:117-27
pubmed: 10442171
J Cell Physiol. 2007 Feb;210(2):398-410
pubmed: 17111364
Brain Behav Immun. 2017 Aug;64:208-219
pubmed: 28089638
BMC Musculoskelet Disord. 2010 Jul 20;11:165
pubmed: 20646281
Pain. 2004 Dec;112(3):324-334
pubmed: 15561388
Semin Arthritis Rheum. 2021 Feb;51(1):219-229
pubmed: 33385862
Exp Physiol. 2002 Sep;87(5):519-25
pubmed: 12481925
Ageing Res Rev. 2020 Dec;64:101185
pubmed: 32992047
Emotion. 2012 Oct;12(5):1015-20
pubmed: 22309720
Lancet. 2001 Mar 10;357(9258):763-7
pubmed: 11253971
FASEB J. 2006 Oct;20(12):2174-6
pubmed: 16912152
Neurology. 2013 Jan 1;80(1):106-17
pubmed: 23267031
Sleep Med. 2014 Dec;15(12):1565-70
pubmed: 25311836
Ann N Y Acad Sci. 2019 Feb;1437(1):57-67
pubmed: 29752710
J Am Acad Orthop Surg. 2013 Oct;21(10):644-6
pubmed: 24084439
PLoS One. 2014 Oct 22;9(10):e110653
pubmed: 25337938
J Orthop Res. 2010 Mar;28(3):298-307
pubmed: 19743505
Eur Spine J. 2018 Apr;27(4):763-777
pubmed: 29460011
Neurosci Biobehav Rev. 2009 Apr;33(4):493-7
pubmed: 19415818
Mol Med Rep. 2013 Sep;8(3):877-82
pubmed: 23827951
BMC Musculoskelet Disord. 2020 Jan 30;21(1):57
pubmed: 32000751
Clin Sci (Lond). 2007 Mar;112(5):305-14
pubmed: 17064252
Am J Physiol Renal Physiol. 2010 Sep;299(3):F545-58
pubmed: 20576680
Cancer Lett. 2020 Aug 1;484:29-39
pubmed: 32344015
Skelet Muscle. 2011 May 04;1(1):21
pubmed: 21798099
J Orthop Res. 2003 Jan;21(1):167-76
pubmed: 12507595
Spine (Phila Pa 1976). 2018 Oct 15;43(20):E1184-E1194
pubmed: 30273227
Phys Ther. 2002 Feb;82(2):173-87
pubmed: 11856068
Exp Gerontol. 2020 Aug;137:110964
pubmed: 32407865
Mol Cell Biol. 2016 Nov 14;36(23):2956-2966
pubmed: 27644327
Pain. 2019 Mar;160(3):632-644
pubmed: 30461558
Metabolism. 2002 Jul;51(7):887-92
pubmed: 12077736
J Neurol Sci. 2016 Feb 15;361:168-80
pubmed: 26810536
BMC Musculoskelet Disord. 2013 Oct 25;14:303
pubmed: 24156755
J Allergy Clin Immunol. 2005 May;115(5):911-9; quiz 920
pubmed: 15867843
Br J Nutr. 2011 Dec;106 Suppl 3:S5-78
pubmed: 22133051
FASEB J. 2014 Apr;28(4):1711-23
pubmed: 24378873
Alcohol Clin Exp Res. 2006 Dec;30(12):2065-78
pubmed: 17117972
Am J Physiol Regul Integr Comp Physiol. 2010 May;298(5):R1173-87
pubmed: 20219869
BMC Med. 2013 Sep 12;11:200
pubmed: 24228900
Arch Intern Med. 2006 Sep 18;166(16):1756-62
pubmed: 16983055
J Stud Alcohol. 1992 Jan;53(1):5-16
pubmed: 1556858
Trends Immunol. 2006 Jan;27(1):24-31
pubmed: 16316783
Biol Psychiatry. 2010 Mar 1;67(5):446-57
pubmed: 20015486
PLoS One. 2013 Nov 19;8(11):e80471
pubmed: 24260397
Int J Mol Sci. 2020 May 18;21(10):
pubmed: 32443588
Eur J Pain. 2009 Aug;13(7):731-6
pubmed: 18976942
Psychopharmacology (Berl). 2003 Dec;170(4):429-33
pubmed: 12955291
Ann Behav Med. 1997 Summer;19(3):279-86
pubmed: 9603702
J Pathol. 2011 Dec;225(4):490-501
pubmed: 21826667
Curr Pharm Des. 2008;14(32):3408-16
pubmed: 19075717
Alcohol Alcohol. 2011 Sep-Oct;46(5):529-33
pubmed: 21636604
Hum Mol Genet. 2009 Feb 1;18(3):482-96
pubmed: 18996917
Sports Med. 2001 Feb;31(2):115-44
pubmed: 11227979
J Mot Behav. 2011;43(6):465-76
pubmed: 22087754
Chronic Stress (Thousand Oaks). 2017 Feb;1:
pubmed: 28795169
Pain Med. 2020 Nov 1;21(11):2975-2985
pubmed: 32232467
Front Psychol. 2018 Apr 27;9:509
pubmed: 29755380
BMJ Open. 2013 Aug 19;3(8):e003036
pubmed: 23959751
Clin Rheumatol. 1992 Jun;11(2):202-5
pubmed: 1617893
J Cell Commun Signal. 2015 Mar;9(1):37-54
pubmed: 25617052
Eur Spine J. 2018 Aug;27(8):1744-1756
pubmed: 29948327
Pain. 2014 Oct;155(10):1976-85
pubmed: 25016218
Nat Rev Neurosci. 2008 Jan;9(1):46-56
pubmed: 18073775
PLoS One. 2012;7(12):e51097
pubmed: 23227240
Alcohol Res Health. 2003;27(3):209-19
pubmed: 15535449
Eur J Appl Physiol. 2013 Jan;113(1):241-8
pubmed: 22677919
BMC Neurosci. 2017 Mar 29;18(1):36
pubmed: 28356066
Obes Rev. 2017 Jul;18(7):776-790
pubmed: 28474421
Sleep. 2007 Sep;30(9):1145-52
pubmed: 17910386
Nat Rev Rheumatol. 2015 Feb;11(2):86-97
pubmed: 25422002
J Immunol. 2020 Sep 15;205(6):1664-1677
pubmed: 32817369
J Clin Invest. 2005 Jan;115(1):56-65
pubmed: 15630444
J Neuroendocrinol. 2001 Dec;13(12):1009-23
pubmed: 11722697
Aging Dis. 2012 Feb;3(1):130-40
pubmed: 22500274
J Cell Death. 2014 May 08;7:15-23
pubmed: 25278783
Med Sci Monit. 2015 Dec 24;21:4030-8
pubmed: 26704133
Shock. 2003 Jun;19(6):538-46
pubmed: 12785009
Pharmacol Ther. 2011 May;130(2):226-38
pubmed: 21334376
Curr Neuropharmacol. 2018;16(5):533-558
pubmed: 29173175
J Orthop Translat. 2018 Feb 07;13:25-32
pubmed: 29662788
Nicotine Tob Res. 2021 Jan 7;23(1):143-151
pubmed: 31965191
Am J Respir Cell Mol Biol. 2006 Dec;35(6):689-96
pubmed: 16794259
Connect Tissue Res. 2020 Nov;61(6):604-619
pubmed: 31443618
Atherosclerosis. 2005 Dec;183(2):308-15
pubmed: 16285994
J Biomed Sci. 2021 Mar 3;28(1):15
pubmed: 33658022
Scand J Work Environ Health. 2002 Jun;28(3):168-75
pubmed: 12109556
J Natl Cancer Inst. 2017 Aug 1;109(8):
pubmed: 28376190
J Cell Physiol. 2010 Oct;225(1):152-67
pubmed: 20458732
Biol Psychiatry. 2008 Sep 15;64(6):538-40
pubmed: 18561896
J Dent Res. 2012 Feb;91(2):142-9
pubmed: 21876032
Spine (Phila Pa 1976). 2020 Feb 15;45(4):E189-E195
pubmed: 31513095
J Orthop Res. 2019 Sep;37(9):2004-2018
pubmed: 31041999
Int J Mol Sci. 2020 May 28;21(11):
pubmed: 32481704
Mol Med Rep. 2012 Jul;6(1):93-9
pubmed: 22552745
Mediators Inflamm. 2008;2008:109502
pubmed: 19148295
Nutrients. 2018 Mar 23;10(4):
pubmed: 29570618
J Physiol. 2001 Oct 15;536(Pt 2):329-37
pubmed: 11600669
World J Gastroenterol. 2010 Mar 21;16(11):1304-13
pubmed: 20238396
Appl Physiol Nutr Metab. 2007 Oct;32(5):833-9
pubmed: 18059606
Eur J Pharmacol. 2004 Oct 1;500(1-3):399-411
pubmed: 15464048
Immunity. 2016 Mar 15;44(3):450-462
pubmed: 26982353
Arthritis Res Ther. 2010;12(3):R89
pubmed: 20478029
Aging Cell. 2015 Aug;14(4):678-88
pubmed: 26009878
Physiol Rev. 2004 Apr;84(2):649-98
pubmed: 15044685
Spine (Phila Pa 1976). 2014 Jun 1;39(13):1010-7
pubmed: 24718080
Neuropsychopharmacology. 2017 Jan;42(1):129-155
pubmed: 27510422
Nat Med. 2015 Jul;21(7):665-6
pubmed: 26151325
Semin Arthritis Rheum. 1987 Feb;16(3):153-7
pubmed: 3547654
Nat Rev Immunol. 2019 Nov;19(11):702-715
pubmed: 31289370
FEBS J. 2013 Sep;280(17):4131-48
pubmed: 23663276
JAMA Psychiatry. 2014 Dec 1;71(12):1381-91
pubmed: 25322082
J Clin Endocrinol Metab. 1999 Aug;84(8):2603-7
pubmed: 10443646
Brain Behav Immun. 2017 Feb;60:84-92
pubmed: 27720935
Respir Med. 2014 Jul;108(7):999-1006
pubmed: 24863424
Neurosci Biobehav Rev. 2015 Jun;53:139-59
pubmed: 25857253
Br J Nutr. 2013 Jan;109 Suppl 1:S1-34
pubmed: 23343744
Br J Surg. 2006 Oct;93(10):1290-6
pubmed: 16838391
Pain. 2008 Dec;140(3):479-490
pubmed: 19006649
Physiol Rev. 2000 Jul;80(3):1055-81
pubmed: 10893431
Nat Rev Immunol. 2011 Aug 05;11(9):607-15
pubmed: 21818123
J Immunol. 2011 Nov 15;187(10):5419-28
pubmed: 22013114
Annu Rev Psychol. 2015 Jan 3;66:143-72
pubmed: 25061767
Brain Behav Immun. 2015 Jul;47:86-92
pubmed: 25451613
Alcohol Res. 2017;38(2):207-217
pubmed: 28988574
Psychosom Med. 2003 Jan-Feb;65(1):75-85
pubmed: 12554818
Hum Mol Genet. 2015 Apr 15;24(8):2147-62
pubmed: 25552658
Arthritis Res Ther. 2017 Jan 23;19(1):12
pubmed: 28114971
Brain Behav Immun. 2017 Feb;60:1-12
pubmed: 26995317
Eur Spine J. 2019 May;28(5):893-904
pubmed: 30737621
Sleep Med Rev. 2015 Apr;20:59-72
pubmed: 25127157
Oncotarget. 2018 Apr 6;9(26):18494-18509
pubmed: 29719620