Expression of RUNX1-JAK2 in Human Induced Pluripotent Stem Cell-Derived Hematopoietic Cells Activates the JAK-STAT and MYC Pathways.
Cell Differentiation
Cells, Cultured
Core Binding Factor Alpha 2 Subunit
/ genetics
Gene Expression Profiling
/ methods
Hematopoietic Stem Cells
/ cytology
Humans
Induced Pluripotent Stem Cells
/ cytology
Janus Kinase 2
/ genetics
Oncogene Proteins, Fusion
/ genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/ genetics
Proto-Oncogene Proteins c-myc
/ metabolism
STAT Transcription Factors
/ metabolism
Signal Transduction
CRISPR/Cas9
JAK-STAT signaling
MYC pathway
hematopoiesis
hiPSC
leukemia
oncogenic fusion
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Jul 2021
15 Jul 2021
Historique:
received:
18
06
2021
accepted:
07
07
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
20
8
2021
Statut:
epublish
Résumé
A heterogeneous genetic subtype of B-cell precursor acute lymphoblastic leukemia is driven by constitutive kinase-activation, including patients with JAK2 fusions. In our study, we model the impact of a novel JAK2 fusion protein on hematopoietic development in human induced pluripotent stem cells (hiPSCs). We insert the
Identifiants
pubmed: 34299194
pii: ijms22147576
doi: 10.3390/ijms22147576
pmc: PMC8304339
pii:
doi:
Substances chimiques
Core Binding Factor Alpha 2 Subunit
0
MYC protein, human
0
Oncogene Proteins, Fusion
0
Proto-Oncogene Proteins c-myc
0
RUNX1 protein, human
0
STAT Transcription Factors
0
JAK2 protein, human
EC 2.7.10.2
Janus Kinase 2
EC 2.7.10.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Österreichische Forschungsförderungsgesellschaft
ID : 843456
Organisme : Austrian Society for Pediatrics and Adolescent Medicine
ID : ÖGKJ scientific prize 2016
Références
Cell Stem Cell. 2017 Mar 2;20(3):315-328.e7
pubmed: 28215825
Leukemia. 2010 Aug;24(8):1516-9
pubmed: 20520637
Methods Mol Biol. 2019;1953:105-119
pubmed: 30912018
Oncogene. 2013 May 23;32(21):2601-13
pubmed: 22869151
Stem Cell Res. 2019 Dec;41:101600
pubmed: 31710911
Nature. 2017 May 11;545(7653):229-233
pubmed: 28445466
Stem Cell Reports. 2016 Oct 11;7(4):602-618
pubmed: 27666791
Blood. 2013 Dec 12;122(25):4035-46
pubmed: 24124087
Stem Cell Reports. 2020 Jan 14;14(1):122-137
pubmed: 31839543
Leukemia. 2007 Aug;21(8):1843-5
pubmed: 17443220
Best Pract Res Clin Haematol. 2017 Sep;30(3):212-221
pubmed: 29050694
Stem Cells. 2004;22(7):1191-204
pubmed: 15579639
Int J Cancer. 2017 Mar 1;140(5):1000-1008
pubmed: 27778348
Blood. 1998 Jun 1;91(11):4028-37
pubmed: 9596646
Cell Stem Cell. 2017 Mar 2;20(3):329-344.e7
pubmed: 28089908
Nat Biotechnol. 2016 Feb;34(2):184-191
pubmed: 26780180
Hemasphere. 2019 Dec 16;4(1):e312
pubmed: 32072137
Blood. 2015 Feb 19;125(8):1282-91
pubmed: 25515960
Genes Dev. 2018 Jun 1;32(11-12):849-864
pubmed: 29907650
Blood. 2006 Sep 15;108(6):2095-105
pubmed: 16757688
Nature. 2009 Oct 8;461(7265):819-22
pubmed: 19783980
Genes (Basel). 2017 May 13;8(5):
pubmed: 28505071
Acta Haematol. 2019;142(2):105-112
pubmed: 31063994
Genome Biol. 2014;15(12):550
pubmed: 25516281
Stem Cells. 2017 Sep;35(9):2095-2102
pubmed: 28758276
Nat Rev Cancer. 2008 Jan;8(1):51-6
pubmed: 18046334
Cancer Genet Cytogenet. 2002 Jun;135(2):110-9
pubmed: 12127395
Nucleic Acids Res. 2013 May 1;41(10):e108
pubmed: 23558742
Blood. 2017 Apr 13;129(15):2070-2082
pubmed: 28179279
Nature. 2009 Feb 12;457(7231):887-91
pubmed: 19129762
Curr Opin Oncol. 2007 Jan;19(1):55-60
pubmed: 17133113
Blood. 2013 Apr 11;121(15):2882-90
pubmed: 23372166
J Exp Med. 2011 Jun 6;208(6):1135-49
pubmed: 21606506
Science. 1997 Nov 14;278(5341):1309-12
pubmed: 9360930
J Exp Med. 2004 Sep 6;200(5):623-35
pubmed: 15353555
Development. 2018 Mar 12;145(5):
pubmed: 29530939
Hemasphere. 2018 Jun 20;2(4):e53
pubmed: 31723781
Hepatology. 2010 Nov;52(5):1808-18
pubmed: 21038417
Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10431-4
pubmed: 1720541
Front Cell Dev Biol. 2017 Dec 20;5:111
pubmed: 29326930
Nat Methods. 2015 Sep;12(9):823-6
pubmed: 26167643
Blood. 2007 Oct 15;110(8):2880-8
pubmed: 17630355
Leukemia. 2018 Aug;32(8):1713-1726
pubmed: 29728695
Cell. 2012 Sep 28;151(1):56-67
pubmed: 23021215
Biostatistics. 2017 Apr 1;18(2):275-294
pubmed: 27756721
Exp Hematol. 2007 Nov;35(11):1668-76
pubmed: 17976519
Stem Cells Dev. 2018 Oct 1;27(19):1376-1384
pubmed: 30009677
J Cell Sci. 2004 Mar 15;117(Pt 8):1281-3
pubmed: 15020666
Br J Haematol. 2017 Mar;176(6):867-882
pubmed: 27984637
Nat Chem Biol. 2018 May;14(5):431-441
pubmed: 29581585
Haematologica. 2016 Apr;101(4):407-16
pubmed: 27033238
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Front Oncol. 2018 Jul 31;8:287
pubmed: 30109213
Eur J Hum Genet. 2017 Aug;25(8):1020-1024
pubmed: 28513614
J Biochem. 1997 Nov;122(5):977-82
pubmed: 9443813
Dev Cell. 2018 Feb 5;44(3):362-377.e7
pubmed: 29290585
Methods Mol Biol. 2004;263:67-94
pubmed: 14976361
Cell Res. 2018 Feb;28(2):172-186
pubmed: 29148541
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Cancer Lett. 2013 May 10;332(1):30-4
pubmed: 23340173
Mol Cell Biol. 2008 Nov;28(21):6668-80
pubmed: 18779318
Curr Opin Immunol. 2010 Apr;22(2):168-76
pubmed: 20227268
Leukemia. 2018 Jan;32(1):38-48
pubmed: 28555080
Nat Genet. 2020 Jul;52(7):662-668
pubmed: 32424350
Cytokine. 2019 Jun;118:48-63
pubmed: 29685781
Cold Spring Harb Perspect Med. 2020 Jul 1;10(7):
pubmed: 31653664
Blood. 2015 Jun 4;125(23):3570-9
pubmed: 25911237
Haematologica. 2015 Oct;100(10):1240-53
pubmed: 26432382
Growth Factors. 2011 Dec;29(6):245-52
pubmed: 21892841
Semin Cancer Biol. 2006 Aug;16(4):288-302
pubmed: 16938463
Nat Methods. 2015 Feb;12(2):115-21
pubmed: 25633503
Haematologica. 2014 Apr;99(4):e52-4
pubmed: 24510341
Adv Exp Med Biol. 2017;962:47-64
pubmed: 28299650
Nature. 2017 May 25;545(7655):432-438
pubmed: 28514439
Nature. 2020 Jul;583(7818):845-851
pubmed: 32699415
Nucleic Acids Res. 2020 Jan 24;48(2):974-995
pubmed: 31799604
Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3444-9
pubmed: 8622955
Nat Commun. 2017 Sep 22;8(1):657
pubmed: 28939824
Bioinformatics. 2015 Sep 15;31(18):3078-80
pubmed: 25979474
N Engl J Med. 2014 Sep 11;371(11):1005-15
pubmed: 25207766