Hypertrophy of Rat Skeletal Muscle Is Associated with Increased SIRT1/Akt/mTOR/S6 and Suppressed Sestrin2/SIRT3/FOXO1 Levels.
Animals
Cystathionine beta-Synthase
/ metabolism
Hypertrophy
/ genetics
Male
Muscle Proteins
/ genetics
Muscle, Skeletal
/ metabolism
Nerve Tissue Proteins
/ antagonists & inhibitors
Nuclear Proteins
/ antagonists & inhibitors
Proto-Oncogene Proteins c-akt
/ genetics
Rats
Rats, Wistar
Ribosomal Protein S6 Kinases
/ genetics
Sirtuin 1
/ genetics
Sirtuins
/ antagonists & inhibitors
TOR Serine-Threonine Kinases
/ genetics
anabolic signaling pathways
overload-induced hypertrophy
redox regulation
skeletal muscle
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Jul 2021
15 Jul 2021
Historique:
received:
26
06
2021
revised:
12
07
2021
accepted:
13
07
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
18
8
2021
Statut:
epublish
Résumé
Despite the intensive investigation of the molecular mechanism of skeletal muscle hypertrophy, the underlying signaling processes are not completely understood. Therefore, we used an overload model, in which the main synergist muscles (gastrocnemius, soleus) of the plantaris muscle were surgically removed, to cause a significant overload in the remaining plantaris muscle of 8-month-old Wistar male rats. SIRT1-associated pro-anabolic, pro-catabolic molecular signaling pathways, NAD and H
Identifiants
pubmed: 34299206
pii: ijms22147588
doi: 10.3390/ijms22147588
pmc: PMC8305659
pii:
doi:
Substances chimiques
Muscle Proteins
0
Nerve Tissue Proteins
0
Nuclear Proteins
0
SIRT3 protein, rat
0
Sesn2 protein, rat
0
Foxo1 protein, rat
0
mTOR protein, rat
EC 2.7.1.1
Akt1 protein, rat
EC 2.7.11.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Ribosomal Protein S6 Kinases
EC 2.7.11.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Sirt1 protein, rat
EC 3.5.1.-
Sirtuin 1
EC 3.5.1.-
Sirtuins
EC 3.5.1.-
Cystathionine beta-Synthase
EC 4.2.1.22
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Innovation and Technology Ministry, Hungary
ID : TKP2020-NKA-26
Références
Physiology (Bethesda). 2019 Jul 1;34(4):232-239
pubmed: 31165685
Redox Biol. 2018 Oct;19:46-51
pubmed: 30107294
Oxid Med Cell Longev. 2019 Apr 7;2019:9752698
pubmed: 31089421
Gerontology. 2018;64(2):127-134
pubmed: 29190625
Physiol Rep. 2021 Mar;9(5):e14789
pubmed: 33660929
Toxicol Appl Pharmacol. 2013 Aug 15;271(1):95-105
pubmed: 23651738
Exp Gerontol. 2018 Sep;110:23-34
pubmed: 29751091
Development. 2016 Sep 1;143(17):3050-60
pubmed: 27578176
Acta Physiol (Oxf). 2013 May;208(1):57-65
pubmed: 23181439
Pharmacol Rev. 2017 Oct;69(4):497-564
pubmed: 28978633
F1000Res. 2019 Sep 11;8:
pubmed: 31559011
Arch Biochem Biophys. 2019 Feb 15;662:49-60
pubmed: 30452895
Lipids Health Dis. 2012 Feb 08;11:23
pubmed: 22316301
Cell Mol Life Sci. 2014 May;71(9):1657-71
pubmed: 24232446
Am J Physiol Cell Physiol. 2021 Apr 1;320(4):C591-C601
pubmed: 33471625
Cell Metab. 2013 Jan 8;17(1):73-84
pubmed: 23274085
Science. 2004 Apr 23;304(5670):596-600
pubmed: 15105503
Sports Med. 2014 Aug;44(8):1125-38
pubmed: 24696049
J Inherit Metab Dis. 2011 Feb;34(1):49-55
pubmed: 20821054
Sci Adv. 2020 Jan 01;6(1):eaax8358
pubmed: 31911946
Science. 2010 Mar 5;327(5970):1223-8
pubmed: 20203043
Oncotarget. 2018 Jun 5;9(43):27318
pubmed: 29930768
Science. 2004 Jul 16;305(5682):390-2
pubmed: 15205477
J Physiol. 2017 Jun 1;595(11):3361-3376
pubmed: 28251652
Nat Commun. 2020 Jan 13;11(1):190
pubmed: 31929512
Mol Cell Biol. 2013 Mar;33(6):1104-13
pubmed: 23297346
J Pharm Pharmacol. 2020 Mar;72(3):424-436
pubmed: 31846093
J Clin Med. 2020 Feb 09;9(2):
pubmed: 32050426
Antioxid Redox Signal. 2019 Jan 10;30(2):184-197
pubmed: 29343087
Front Physiol. 2020 Dec 03;11:608474
pubmed: 33343399
Nat Cell Biol. 2001 Nov;3(11):1014-9
pubmed: 11715023
Mediators Inflamm. 2018 Jul 5;2018:6209140
pubmed: 30116150
Int J Mol Sci. 2018 Oct 11;19(10):
pubmed: 30314396
J Biol Chem. 2013 Oct 18;288(42):30515-30526
pubmed: 24003218
Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R1132-9
pubmed: 19176887
Free Radic Biol Med. 2013 May;58:87-97
pubmed: 23339850
Cell. 2008 Aug 8;134(3):451-60
pubmed: 18692468
Methods Enzymol. 2015;554:3-29
pubmed: 25725513
Adv Exp Med Biol. 2018;1088:109-137
pubmed: 30390250
Cell. 2015 Jan 15;160(1-2):132-44
pubmed: 25542313
Am J Physiol Endocrinol Metab. 2016 Sep 1;311(3):E594-604
pubmed: 27382036
FASEB J. 2018 Apr;32(4):1741-1777
pubmed: 29242278
Free Radic Biol Med. 2019 May 20;136:146-158
pubmed: 30970274