Linking Fibrotic Remodeling and Ultrastructural Alterations of Alveolar Epithelial Cells after Deletion of

Airway Remodeling / physiology Alveolar Epithelial Cells / metabolism Animals Epithelial Cells / metabolism Female Fibrosis / metabolism Lung / pathology Male Mice Mice, Knockout Nedd4 Ubiquitin Protein Ligases / genetics Pulmonary Alveoli / pathology Pulmonary Fibrosis / metabolism Pulmonary Surfactants Respiratory Mucosa / metabolism
Nedd4-2 alveolar epithelial type 2 cells alveolar epithelium pulmonary fibrosis regeneration stereology surfactant

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
16 Jul 2021
Historique:
received: 24 05 2021
revised: 09 07 2021
accepted: 11 07 2021
entrez: 24 7 2021
pubmed: 25 7 2021
medline: 13 8 2021
Statut: epublish

Résumé

Our previous study showed that in adult mice, conditional

Identifiants

DOI: 10.3390/ijms22147607 PMID: 34299227 PMC: PMC8306112
pubmed: 34299227
pii: ijms22147607
doi: 10.3390/ijms22147607
pmc: PMC8306112
pii:
doi:

Substances chimiques

Pulmonary Surfactants 0
Nedd4 Ubiquitin Protein Ligases EC 2.3.2.26
Nedd4l protein, mouse EC 2.3.2.26

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Bundesministerium für Bildung, Wissenschaft und Forschung
ID : 82DZL004A1, 82DZL009B1
Organisme : NHLBI NIH HHS
ID : U01 HL152970
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL145408
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES013508
Pays : United States
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB 1449 B01, SFB-TR84 B08, SFB 1449 A01, C04 and Z02, 450557679
Organisme : U.S. Department of Veterans Affairs
ID : R01 HL145408, 2I01BX001176

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Auteurs

Theresa A Engelmann (TA)

Institute for Forensic Medicine, Hannover Medical School, 30625 Hannover, Germany.
Institute of Functional and Applied Anatomy, Hannover Medical School, 30625 Hannover, Germany.

Lars Knudsen (L)

Institute of Functional and Applied Anatomy, Hannover Medical School, 30625 Hannover, Germany.
Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), 30625 Hannover, Germany.
ORCID: 0000-0002-7926-3879

Dominik H W Leitz (DHW)

Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
Department of Translational Pulmonology, Translational Lung Research Center (TLRC), Member of the German Center for Lung Research (DZL), University of Heidelberg, Im Neuenheimer Feld 156, 69120 Heidelberg, Germany.
German Center for Lung Research (DZL), Associated Partner, Augustenburger Platz 1, 13353 Berlin, Germany.
ORCID: 0000-0002-0610-9088

Julia Duerr (J)

Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
Department of Translational Pulmonology, Translational Lung Research Center (TLRC), Member of the German Center for Lung Research (DZL), University of Heidelberg, Im Neuenheimer Feld 156, 69120 Heidelberg, Germany.
German Center for Lung Research (DZL), Associated Partner, Augustenburger Platz 1, 13353 Berlin, Germany.
ORCID: 0000-0002-4862-9487

Michael F Beers (MF)

Pulmonary, Allergy, and Critical Care Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
PENN-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Marcus A Mall (MA)

Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
Department of Translational Pulmonology, Translational Lung Research Center (TLRC), Member of the German Center for Lung Research (DZL), University of Heidelberg, Im Neuenheimer Feld 156, 69120 Heidelberg, Germany.
German Center for Lung Research (DZL), Associated Partner, Augustenburger Platz 1, 13353 Berlin, Germany.
Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
ORCID: 0000-0002-4057-2199

Matthias Ochs (M)

German Center for Lung Research (DZL), Associated Partner, Augustenburger Platz 1, 13353 Berlin, Germany.
Institute of Functional Anatomy, Charité, Universitätsmedizin Berlin, 10117 Berlin, Germany.
ORCID: 0000-0002-0936-6979

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Remodelage des voies aériennes › Linking Fibrotic Remodeling and...
questionsmedicales.fr › Cellules › Cellules épithéliales › Pneumocytes › Linking Fibrotic Remodeling and...
questionsmedicales.fr › Eucaryotes › Animaux › Linking Fibrotic Remodeling and...
questionsmedicales.fr › Cellules › Cellules épithéliales › Linking Fibrotic Remodeling and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Linking Fibrotic Remodeling and...
questionsmedicales.fr › Appareil respiratoire › Poumon › Linking Fibrotic Remodeling and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Linking Fibrotic Remodeling and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Linking Fibrotic Remodeling and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › Complexes de tri endosomique requis pour le transport › Ubiquitine protéine ligases NEDD4 › Linking Fibrotic Remodeling and...
questionsmedicales.fr › Appareil respiratoire › Poumon › Alvéoles pulmonaires › Linking Fibrotic Remodeling and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Fibrose pulmonaire › Linking Fibrotic Remodeling and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents de l'appareil respiratoire › Surfactants pulmonaires › Linking Fibrotic Remodeling and...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse respiratoire › Linking Fibrotic Remodeling and...