Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues.
Adipokines
/ metabolism
Adiponectin
/ metabolism
Adipose Tissue
/ metabolism
Adipose Tissue, Beige
/ metabolism
Adipose Tissue, Brown
/ metabolism
Adipose Tissue, White
/ metabolism
Animals
Diabetes Complications
/ metabolism
Diabetes Mellitus
/ metabolism
Energy Metabolism
/ physiology
Humans
Insulin
/ metabolism
Insulin Resistance
/ physiology
Leptin
/ metabolism
Obesity
/ metabolism
adipose
diabetes mellitus
insulin resistance
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Jul 2021
16 Jul 2021
Historique:
received:
15
06
2021
revised:
08
07
2021
accepted:
12
07
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
5
8
2021
Statut:
epublish
Résumé
Many approaches have been used in the effective management of type 2 diabetes mellitus. A recent paradigm shift has focused on the role of adipose tissues in the development and treatment of the disease. Brown adipose tissues (BAT) and white adipose tissues (WAT) are the two main types of adipose tissues with beige subsets more recently identified. They play key roles in communication and insulin sensitivity. However, WAT has been shown to contribute significantly to endocrine function. WAT produces hormones and cytokines, collectively called adipocytokines, such as leptin and adiponectin. These adipocytokines have been proven to vary in conditions, such as metabolic dysfunction, type 2 diabetes, or inflammation. The regulation of fat storage, energy metabolism, satiety, and insulin release are all features of adipose tissues. As such, they are indicators that may provide insights on the development of metabolic dysfunction or type 2 diabetes and can be considered routes for therapeutic considerations. The essential roles of adipocytokines vis-a-vis satiety, appetite, regulation of fat storage and energy, glucose tolerance, and insulin release, solidifies adipose tissue role in the development and pathogenesis of diabetes mellitus and the complications associated with the disease.
Identifiants
pubmed: 34299261
pii: ijms22147644
doi: 10.3390/ijms22147644
pmc: PMC8305176
pii:
doi:
Substances chimiques
Adipokines
0
Adiponectin
0
Insulin
0
Leptin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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