Opportunities and Challenges of Liquid Biopsy in Thyroid Cancer.
anaplastic thyroid cancer
diagnosis
differentiated thyroid cancer
liquid biopsy
medullary thyroid cancer
prognosis
therapy
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Jul 2021
19 Jul 2021
Historique:
received:
22
06
2021
revised:
09
07
2021
accepted:
12
07
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
12
8
2021
Statut:
epublish
Résumé
Thyroid cancer is the most common malignancy of the endocrine system, encompassing different entities with distinct histological features and clinical behavior. The diagnostic definition, therapeutic approach, and follow-up of thyroid cancers display some controversial aspects that represent unmet medical needs. Liquid biopsy is a non-invasive approach that detects and analyzes biological samples released from the tumor into the bloodstream. With the use of different technologies, tumor cells, free nucleic acids, and extracellular vesicles can be retrieved in the serum of cancer patients and valuable molecular information can be obtained. Recently, a growing body of evidence is accumulating concerning the use of liquid biopsy in thyroid cancer, as it can be exploited to define a patient's diagnosis, estimate their prognosis, and monitor tumor recurrence or treatment response. Indeed, liquid biopsy can be a valuable tool to overcome the limits of conventional management of thyroid malignancies. In this review, we summarize currently available data about liquid biopsy in differentiated, poorly differentiated/anaplastic, and medullary thyroid cancer, focusing on circulating tumor cells, circulating free nucleic acids, and extracellular vesicles.
Identifiants
pubmed: 34299334
pii: ijms22147707
doi: 10.3390/ijms22147707
pmc: PMC8303548
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Cell-Free Nucleic Acids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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