Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family.
PIM kinases
adenosine–arginine conjugate
bisubstrate inhibitors
cellular uptake and localization
co-crystal structure
fluorescent probes
protein X-ray crystallography
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
19 Jul 2021
19 Jul 2021
Historique:
received:
01
06
2021
revised:
09
07
2021
accepted:
14
07
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
18
9
2021
Statut:
epublish
Résumé
We performed an X-ray crystallographic study of complexes of protein kinase PIM-1 with three inhibitors comprising an adenosine mimetic moiety, a linker, and a peptide-mimetic (d-Arg)
Identifiants
pubmed: 34299628
pii: molecules26144353
doi: 10.3390/molecules26144353
pmc: PMC8307404
pii:
doi:
Substances chimiques
Carbocyanines
0
Fluorescent Dyes
0
Peptidomimetics
0
Protein Kinase Inhibitors
0
cyanine dye 5
0
PIM1 protein, human
EC 2.7.11.1
Proto-Oncogene Proteins c-pim-1
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Eesti Teadusagentuur
ID : PRG454
Organisme : Eesti Teadusagentuur
ID : PSG230
Organisme : Medical Research Council and the Nuffield Department of Medicine, University of Oxford
ID : NDM Prize Studentship
Organisme : German translational cancer network
ID : (DKTK)
Organisme : Frankfurt Cancer Institute
ID : (FCI)
Organisme : Genome Canada through Ontario Genomics Institute
ID : OGI-196
Organisme : EU/EFPIA/OICR/McGill/KTH/Diamond
ID : SGC no. 1097737
Organisme : Innovative Medicines Initiative 2 Joint Undertaking EUbOPEN
ID : 875510
Organisme : Wellcome Trust
ID : 106169/ZZ14/Z
Pays : United Kingdom
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