GWAS
hemorrhagic transformation
parenchymal hematoma
single nucleotide variants
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
16 Jul 2021
16 Jul 2021
Historique:
received:
07
06
2021
revised:
05
07
2021
accepted:
14
07
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
25
7
2021
Statut:
epublish
Résumé
Stroke is one of the most common causes of death and disability. Reperfusion therapies are the only treatment available during the acute phase of stroke. Due to recent clinical trials, these therapies may increase their frequency of use by extending the time-window administration, which may lead to an increase in complications such as hemorrhagic transformation, with parenchymal hematoma (PH) being the more severe subtype, associated with higher mortality and disability rates. Our aim was to find genetic risk factors associated with PH, as that could provide molecular targets/pathways for their prevention/treatment and study its genetic correlations to find traits sharing genetic background. We performed a GWAS and meta-analysis, following standard quality controls and association analysis (fastGWAS), adjusting age, NIHSS, and principal components. FUMA was used to annotate, prioritize, visualize, and interpret the meta-analysis results. The total number of patients in the meta-analysis was 2034 (216 cases and 1818 controls). We found rs79770152 having a genome-wide significant association (beta 0.09,
Identifiants
pubmed: 34300314
pii: jcm10143137
doi: 10.3390/jcm10143137
pmc: PMC8305811
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Instituto de Salud Carlos III
ID : CM18/00198
Organisme : Agència de Gestió d'Ajuts Universitaris i de Recerca
ID : 2020FI_B1 00157
Organisme : European Social Fund
ID : 2020FI_B1 00157
Organisme : Instituto de Salud Carlos III
ID : CD20/00043
Organisme : European Regional Development Fund
ID : CD20/00043
Organisme : Instituto de Salud Carlos III
ID : FI19/00309
Organisme : Instituto de Salud Carlos III
ID : CP12/03298
Organisme : Instituto de Salud Carlos III
ID : CPII17/00027
Organisme : Instituto de Salud Carlos III
ID : CPII19/00020
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