Gender and Sex Are Key Determinants in Osteoarthritis Not Only Confounding Variables. A Systematic Review of Clinical Data.
clinical studies
gender
men
osteoarthritis
patients
sex
women
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
19 Jul 2021
19 Jul 2021
Historique:
received:
23
06
2021
revised:
08
07
2021
accepted:
16
07
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
25
7
2021
Statut:
epublish
Résumé
Many risk factors for osteoarthritis (OA) have been noted, while gender/sex differences have been understated. The work aimed to systematically review literature investigating as primary aim the relationship between gender/sex related discriminants and OA. The search was performed in PubMed, Science Direct and Web of Knowledge in the last 10 years. Inclusion criteria were limited to clinical studies of patients affected by OA in any joints, analyzing as primary aim gender/sex differences. Exclusion criteria were review articles, in vitro, in vivo and ex vivo studies, case series studies and papers in which gender/sex differences were adjusted as confounding variable. Of the 120 records screened, 42 studies were included. Different clinical outcomes were analyzed: morphometric differences, followed by kinematics, pain, functional outcomes after arthroplasty and health care needs of patients. Women appear to use more health care, have higher OA prevalence, clinical pain and inflammation, decreased cartilage volume, physical difficulty, and smaller joint parameters and dimensions, as compared to men. No in-depth studies or mechanistic studies analyzing biomarker differential expressions, molecular pathways and omic profiles were found that might drive preclinical and clinical research towards sex-/gender-oriented protocols.
Identifiants
pubmed: 34300344
pii: jcm10143178
doi: 10.3390/jcm10143178
pmc: PMC8303951
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Ministero della Salute
ID : RCR-2020-23670069_001
Références
Int J Mol Sci. 2020 May 24;21(10):
pubmed: 32456298
Osteoarthritis Cartilage. 2017 Jul;25(7):1100-1106
pubmed: 28163248
Pain Rep. 2017 Apr 20;2(3):e595
pubmed: 29392211
Osteoarthritis Cartilage. 2005 Sep;13(9):769-81
pubmed: 15978850
Br J Anaesth. 2013 Jul;111(1):52-8
pubmed: 23794645
J Womens Health (Larchmt). 2018 Nov;27(11):1342-1348
pubmed: 30307789
Osteoarthritis Cartilage. 2014 Aug;22(8):1100-6
pubmed: 24999111
Pain Med. 2016 Dec;17(12):2305-2310
pubmed: 28025364
Osteoarthritis Cartilage. 2021 Aug;29(8):1096-1116
pubmed: 33971205
J Shoulder Elbow Surg. 2017 Nov;26(11):1889-1896
pubmed: 28911814
Exp Gerontol. 2015 Dec;72:16-21
pubmed: 26343257
Am J Sports Med. 2016 Mar;44(3):664-71
pubmed: 26797697
Clin Biomech (Bristol, Avon). 2017 Oct;48:24-29
pubmed: 28708989
Rheumatology (Oxford). 2009 Sep;48(9):1160-5
pubmed: 19608726
Gene. 2014 Mar 10;537(2):184-8
pubmed: 24333346
Osteoarthritis Cartilage. 2016 Mar;24(3):443-50
pubmed: 26497609
Osteoarthritis Cartilage. 2010 May;18(5):640-5
pubmed: 20167302
Biol Sex Differ. 2011 Nov 10;2:12
pubmed: 22074728
Arthritis Rheumatol. 2020 Feb;72(2):220-233
pubmed: 31908163
Nat Neurosci. 2015 Aug;18(8):1081-3
pubmed: 26120961
PLoS Med. 2009 Jul 21;6(7):e1000097
pubmed: 19621072
Womens Health (Lond). 2010 Jul;6(4):601-15
pubmed: 20597623
Clin Biomech (Bristol, Avon). 2017 Nov;49:72-77
pubmed: 28892670
Arch Phys Med Rehabil. 2016 Jul;97(7):1154-62
pubmed: 27063363
Clin Exp Rheumatol. 2019 Sep-Oct;37 Suppl 120(5):3-6
pubmed: 31621562
Arthritis Res Ther. 2010;12(4):212
pubmed: 20701741
Skeletal Radiol. 2001 Mar;30(3):144-50
pubmed: 11357452
Clin Biomech (Bristol, Avon). 2012 Jul;27(6):584-7
pubmed: 22406298
Clin Orthop Relat Res. 2011 Jul;469(7):1846-51
pubmed: 21267799
Osteoarthritis Cartilage. 2017 Jan;25(1):53-59
pubmed: 27546883
Front Biosci (Elite Ed). 2012 Jun 01;4:2586-606
pubmed: 22652670
Ann Phys Rehabil Med. 2016 Jun;59(3):134-138
pubmed: 26904959
Semin Arthritis Rheum. 2015 Dec;45(3):268-74
pubmed: 26250956
J Arthroplasty. 2015 Jul;30(7):1220-7
pubmed: 25752826
J Gerontol A Biol Sci Med Sci. 2015 Mar;70(3):339-44
pubmed: 25063080
Osteoarthritis Cartilage. 2014 Aug;22(8):1129-35
pubmed: 24971867
Semin Arthritis Rheum. 2018 Jun;47(6):805-813
pubmed: 29157670
Gend Med. 2012 Dec;9(6):457-62
pubmed: 23141296
Curr Opin Rheumatol. 2001 Sep;13(5):447-51
pubmed: 11604603
Bone. 2013 Jan;52(1):516-23
pubmed: 23103329
Pain Med. 2018 Nov 1;19(11):2146-2153
pubmed: 29206993
Arch Phys Med Rehabil. 2014 Dec;95(12):2376-81
pubmed: 25152171
BMC Musculoskelet Disord. 2016 Apr 12;17:157
pubmed: 27072641
J Bone Joint Surg Br. 2012 May;94(5):638-41
pubmed: 22529083
Mech Ageing Dev. 2019 Jun;180:21-28
pubmed: 30898635
J Arthroplasty. 2013 Aug;28(7):1117-20
pubmed: 23123041
Knee. 2018 Jan;25(1):40-50
pubmed: 29174844
Knee Surg Sports Traumatol Arthrosc. 2017 Feb;25(2):468-476
pubmed: 27262696
Pain Med. 2003 Sep;4(3):277-94
pubmed: 12974827
BMC Musculoskelet Disord. 2010 Jun 22;11:129
pubmed: 20569450
Curr Opin Rheumatol. 2018 Mar;30(2):160-167
pubmed: 29227353
J Arthroplasty. 2011 Oct;26(7):994-9
pubmed: 21414750
J Cell Physiol. 2017 Jun;232(6):1478-1488
pubmed: 27739057
Clin J Pain. 2017 Feb;33(2):174-180
pubmed: 28060784
Trends Biotechnol. 2019 Oct;37(10):1063-1077
pubmed: 31000204
Arthritis Care Res (Hoboken). 2020 Jul;72(7):991-1000
pubmed: 31207113
J Arthroplasty. 2011 Oct;26(7):984-8
pubmed: 21316917
Hum Mol Genet. 2005 Jan 1;14(1):135-43
pubmed: 15537663
Aging Dis. 2021 Apr 1;12(2):625-645
pubmed: 33815887
Int J Sports Med. 2012 Nov;33(11):926-33
pubmed: 22706942
BMC Musculoskelet Disord. 2015 Nov 17;16:359
pubmed: 26578262
Pain. 2001 Nov;94(2):133-137
pubmed: 11690726
Pain Med. 2017 Mar 1;18(3):414-427
pubmed: 27497322
J Bone Miner Metab. 2011 Nov;29(6):633-44
pubmed: 21898177
J Orthop Surg (Hong Kong). 2015 Aug;23(2):194-7
pubmed: 26321549
Spine (Phila Pa 1976). 2012 May 15;37(11):915-22
pubmed: 22024896
J Gerontol A Biol Sci Med Sci. 2020 Jul 13;75(8):1465-1472
pubmed: 31412104
Gait Posture. 2018 Sep;65:234-239
pubmed: 30558937
J Arthroplasty. 2016 Oct;31(10):2115-2118.e1
pubmed: 27157824
Biol Sex Differ. 2012 Dec 17;3(1):26
pubmed: 23244577
Semin Arthritis Rheum. 2018 Feb;47(4):464-471
pubmed: 28941552
Rheumatol Int. 2018 May;38(5):917-924
pubmed: 29147763
CMAJ. 2021 Feb 16;193(7):E244-E250
pubmed: 33593950
Int J Mol Sci. 2019 Dec 31;21(1):
pubmed: 31906252
BMJ Open. 2019 Nov 21;9(11):e033334
pubmed: 31753902
Scand J Pain. 2017 Jul;16:66-73
pubmed: 28850415
BMC Musculoskelet Disord. 2015 Oct 20;16:308
pubmed: 26480822
Bone. 2015 Aug;77:91-7
pubmed: 25892484
J Neuroimmunol. 2018 Aug 15;321:49-60
pubmed: 29957388
Cells. 2020 Jun 28;9(7):
pubmed: 32605161
Sci Rep. 2019 Sep 19;9(1):13603
pubmed: 31537813
J Gerontol A Biol Sci Med Sci. 2014 May;69(5):602-8
pubmed: 24253535
Pain Ther. 2021 Apr 19;:
pubmed: 33876393
Knee. 2016 Jan;23(1):35-42
pubmed: 26365575
J Electromyogr Kinesiol. 2011 Oct;21(5):695-703
pubmed: 21840223
Osteoarthritis Cartilage. 2021 May;29(5):728-738
pubmed: 33609695
Menopause. 2009 Jul-Aug;16(4):666-70
pubmed: 19598333
Clin Orthop Relat Res. 2011 Feb;469(2):348-54
pubmed: 20700673
J Biomech. 2014 Dec 18;47(16):3787-93
pubmed: 25468667
Mol Med. 2021 Jan 15;27(1):5
pubmed: 33446092