Intrabronchial application of extracellular histones shows no proinflammatory effects in swine in a translational pilot study.
ARDS
Experimental
Extracellular histones
Lung damage
Porcine
Sepsis
Journal
BMC research notes
ISSN: 1756-0500
Titre abrégé: BMC Res Notes
Pays: England
ID NLM: 101462768
Informations de publication
Date de publication:
23 Jul 2021
23 Jul 2021
Historique:
received:
08
03
2021
accepted:
19
07
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
28
7
2021
Statut:
epublish
Résumé
Extracellular histones have been identified as one molecular factor that can cause and sustain alveolar damage and were linked to high mortality rates in critically ill patients. In this pilot study, we wanted to validate the proinflammatory in vivo effects of local histone application in a prospective translational porcine model. This was combined with the evaluation of an experimental acute lung injury model using intrabronchial lipopolysaccharides, which has been published previously. The targeted application of histones was successful in all animals. Animals showed decreased oxygenation after instillation, but no differences could be detected between the sham and histone treatments. The histologic analyses and inflammatory responses indicated that there were no differences in tissue damage between the groups.
Identifiants
pubmed: 34301315
doi: 10.1186/s13104-021-05704-7
pii: 10.1186/s13104-021-05704-7
pmc: PMC8306385
doi:
Substances chimiques
Histones
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
285Informations de copyright
© 2021. The Author(s).
Références
Mediators Inflamm. 2017;2017:5928078
pubmed: 28694564
J Immunol. 2011 Sep 1;187(5):2626-31
pubmed: 21784973
Clinics (Sao Paulo). 2015 Aug;70(8):577-83
pubmed: 26247671
FASEB J. 2013 Dec;27(12):5010-21
pubmed: 23982144
J Trauma Acute Care Surg. 2012 Dec;73(6):1389-94
pubmed: 23188230
J Mol Med (Berl). 2014 May;92(5):465-72
pubmed: 24706102
Sci Rep. 2017 Jun 19;7(1):3795
pubmed: 28630422
F1000Res. 2013 Jul 08;2:148
pubmed: 24358859
Radiat Med. 2001 May-Jun;19(3):131-43
pubmed: 11467380
Anaesthesia. 2015 Oct;70(10):1171-9
pubmed: 26179167
N Engl J Med. 2000 May 4;342(18):1301-8
pubmed: 10793162
Lancet. 1967 Aug 12;2(7511):319-23
pubmed: 4143721
Thromb Res. 2015 Sep;136(3):542-7
pubmed: 26232351
Crit Care Med. 2019 Aug;47(8):e677-e684
pubmed: 31162199
Crit Care Med. 2015 Apr;43(4):e107-16
pubmed: 25654179
Science. 2004 Mar 5;303(5663):1532-5
pubmed: 15001782
Vet Anaesth Analg. 2021 Jan;48(1):26-34
pubmed: 33309470
Biomaterials. 2013 Jul;34(22):5670-6
pubmed: 23623426
Resuscitation. 2018 Nov;132:56-62
pubmed: 30176273
Am J Respir Crit Care Med. 2013 Jan 15;187(2):160-9
pubmed: 23220920
FASEB J. 2015 Sep;29(9):3762-72
pubmed: 25999468
J Vet Med B Infect Dis Vet Public Health. 2002 Nov;49(9):429-37
pubmed: 12489711
Respir Res. 2016 Nov 21;17(1):155
pubmed: 27871277
Mediators Inflamm. 2015;2015:205054
pubmed: 26609197
Nat Med. 2009 Nov;15(11):1318-21
pubmed: 19855397
Respir Res. 2014 Sep 06;15:101
pubmed: 25189285