Clinical utility of a serum biomarker panel in distinguishing prostate cancer from benign prostate hyperplasia.

Aged Biomarkers, Tumor / blood Diagnosis, Differential Humans Male Middle Aged Neoplasm Grading Prostate / metabolism Prostate-Specific Antigen / blood Prostatic Hyperplasia / blood Prostatic Neoplasms / blood

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
23 07 2021
Historique:
received: 11 03 2021
accepted: 06 07 2021
entrez: 24 7 2021
pubmed: 25 7 2021
medline: 28 10 2021
Statut: epublish

Résumé

Prostate-specific antigen (PSA) screening for prostate cancer (PCa) is limited by the lack of specificity but is further complicated in the benign prostatic hyperplasia (BPH) population which also exhibit elevated PSA, representing a clear unmet need to distinguish BPH from PCa. Herein, we evaluated the utility of FLNA IP-MRM, age, and prostate volume to stratify men with BPH from those with PCa. Diagnostic performance of the biomarker panel was better than PSA alone in discriminating patients with negative biopsy from those with PCa, as well as those who have had multiple prior biopsies (AUC 0.75 and 0.87 compared to AUC of PSA alone 0.55 and 0.57 for patients who have had single compared to multiple negative biopsies, respectively). Of interest, in patients with PCa, the panel demonstrated improved performance than PSA alone in those with Gleason scores of 5-7 (AUC 0.76 vs. 0.56) and Gleason scores of 8-10 (AUC 0.74 vs. 0.47). With Gleason scores (8-10), the negative predictive value of the panel is 0.97, indicating potential to limit false negatives in aggressive cancers. Together, these data demonstrate the ability of the biomarker panel to perform better than PSA alone in men with BPH, thus preventing unnecessary biopsies.

Identifiants

DOI: 10.1038/s41598-021-94438-4 PMID: 34302010 PMC: PMC8302659
pubmed: 34302010
doi: 10.1038/s41598-021-94438-4
pii: 10.1038/s41598-021-94438-4
pmc: PMC8302659
doi:

Substances chimiques

Biomarkers, Tumor 0
Prostate-Specific Antigen EC 3.4.21.77

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

15052

Informations de copyright

© 2021. The Author(s).

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Auteurs

Michael A Kiebish (MA)

BERG, 500 Old Connecticut Path, Building B, Framingham, MA, 01701, USA.

Poornima Tekumalla (P)

BERG, 500 Old Connecticut Path, Building B, Framingham, MA, 01701, USA.

Shobha Ravipaty (S)

BERG, 500 Old Connecticut Path, Building B, Framingham, MA, 01701, USA.

Albert Dobi (A)

Center for Prostate Disease Research, John P. Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center, Bethesda, MD, 20817, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20817, USA.

Shiv Srivastava (S)

Center for Prostate Disease Research, John P. Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center, Bethesda, MD, 20817, USA.
Department of Biochemistry and Molecular and Cell Biology, Georgetown University School of Medicine, Washington, DC, 20057, USA.

Wenfang Wu (W)

BERG, 500 Old Connecticut Path, Building B, Framingham, MA, 01701, USA.

Saurabh Patil (S)

BERG, 500 Old Connecticut Path, Building B, Framingham, MA, 01701, USA.

Tracey Friss (T)

BERG, 500 Old Connecticut Path, Building B, Framingham, MA, 01701, USA.

Allison Klotz (A)

BERG, 500 Old Connecticut Path, Building B, Framingham, MA, 01701, USA.

Alagarsamy Srinivasan (A)

Center for Prostate Disease Research, John P. Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center, Bethesda, MD, 20817, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20817, USA.
Nano Bio Diagnostics LLC, West Chester, PA, 19382, USA.

Jennifer Cullen (J)

Center for Prostate Disease Research, John P. Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center, Bethesda, MD, 20817, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20817, USA.
Case Comprehensive Cancer Center, Cleveland, OH, 44106, USA.

Inger L Rosner (IL)

Center for Prostate Disease Research, John P. Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center, Bethesda, MD, 20817, USA.
Inova Health System, Fairfax, VA, 22031, USA.

Amina Ali (A)

Center for Prostate Disease Research, John P. Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center, Bethesda, MD, 20817, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20817, USA.

Sandra Laszlo (S)

University Health Network, Toronto, ON, M5G 2C4, Canada.

Michele Petrovic (M)

University Health Network, Toronto, ON, M5G 2C4, Canada.

Neil Fleshner (N)

University Health Network, Toronto, ON, M5G 2C4, Canada.

Jeonifer Garren (J)

BERG, 500 Old Connecticut Path, Building B, Framingham, MA, 01701, USA.

Greg Miller (G)

BERG, 500 Old Connecticut Path, Building B, Framingham, MA, 01701, USA.

Nischal Mahaveer Chand (N)

BERG, 500 Old Connecticut Path, Building B, Framingham, MA, 01701, USA.

Leonardo O Rodrigues (LO)

BERG, 500 Old Connecticut Path, Building B, Framingham, MA, 01701, USA.

Elder Granger (E)

BERG, 500 Old Connecticut Path, Building B, Framingham, MA, 01701, USA.

Mark D Kellogg (MD)

BERG, 500 Old Connecticut Path, Building B, Framingham, MA, 01701, USA.
Department of Laboratory Medicine and Pathology, Harvard Medical School, Boston Children's Hospital, Boston, MA, 02115, USA.

Shen Luan (S)

BERG, 500 Old Connecticut Path, Building B, Framingham, MA, 01701, USA.

Eleftherios Diamandis (E)

Mount Sinai Hospital, Toronto, ON, M5T 3L9, Canada.

Viatcheslav R Akmaev (VR)

BERG, 500 Old Connecticut Path, Building B, Framingham, MA, 01701, USA.

Rangaprasad Sarangarajan (R)

BERG, 500 Old Connecticut Path, Building B, Framingham, MA, 01701, USA.

Chas Bountra (C)

Department of Clinical Medicine, University of Oxford, Oxford, OX3 7LF, UK.

Stephen J Freedland (SJ)

Center for Integrated Research in Cancer and Lifestyle, Cedar-Sinai, Los Angeles, CA, 90048, USA.
Durham VA Medical Center, Durham, NC, 27705, USA.

David G McLeod (DG)

Center for Prostate Disease Research, John P. Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center, Bethesda, MD, 20817, USA.

Niven R Narain (NR)

BERG, 500 Old Connecticut Path, Building B, Framingham, MA, 01701, USA. Niven.Narain@berghealth.com.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Clinical utility of a serum biomarker panel in...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Clinical utility of a serum biomarker panel in...
questionsmedicales.fr › Diagnostic › Diagnostic différentiel › Clinical utility of a serum biomarker panel in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Clinical utility of a serum biomarker panel in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Clinical utility of a serum biomarker panel in...
questionsmedicales.fr › Diagnostic › Pronostic › Grading des tumeurs › Clinical utility of a serum biomarker panel in...
questionsmedicales.fr › Tissus › Glandes exocrines › Prostate › Clinical utility of a serum biomarker panel in...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Antigène spécifique de la prostate › Clinical utility of a serum biomarker panel in...
questionsmedicales.fr › Maladies urogénitales › Maladies urogénitales de l'homme › Maladies de l'appareil génital mâle › Maladies de la prostate › Hyperplasie de la prostate › Clinical utility of a serum biomarker panel in...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital mâle › Tumeurs de la prostate › Clinical utility of a serum biomarker panel in...