Multipurpose peptides: The venoms of Amazonian stinging ants contain anthelmintic ponericins with diverse predatory and defensive activities.
Amino Acid Sequence
Animals
Ant Venoms
/ genetics
Anthelmintics
/ isolation & purification
Anti-Infective Agents
/ isolation & purification
Ants
Brugia malayi
/ drug effects
Calliphoridae
Dose-Response Relationship, Drug
HEK293 Cells
Haemonchus
/ drug effects
Hemolytic Agents
/ isolation & purification
Humans
Insecticides
/ isolation & purification
Male
Mice
Mice, Inbred C57BL
Peptides
/ genetics
Sheep
Ant
Anthelmintic
Antimicrobial
Pain
Ponericin
Venom peptide
Journal
Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
06
05
2021
revised:
14
07
2021
accepted:
16
07
2021
pubmed:
25
7
2021
medline:
17
11
2021
entrez:
24
7
2021
Statut:
ppublish
Résumé
In the face of increasing drug resistance, the development of new anthelmintics is critical for controlling nematodes that parasitise livestock. Although hymenopteran venom toxins have attracted attention for applications in agriculture and medicine, few studies have explored their potential as anthelmintics. Here we assessed hymenopteran venoms as a possible source of new anthelmintic compounds by screening a panel of ten hymenopteran venoms against Haemonchus contortus, a major pathogenic nematode of ruminants. Using bioassay-guided fractionation coupled with liquid chromatography-tandem mass spectrometry, we identified four novel anthelmintic peptides (ponericins) from the venom of the neotropical ant Neoponera commutata and the previously described ponericin M-PONTX-Na1b from Neoponera apicalis venom. These peptides inhibit H. contortus development with IC
Identifiants
pubmed: 34302796
pii: S0006-2952(21)00306-3
doi: 10.1016/j.bcp.2021.114693
pmc: PMC10167921
mid: NIHMS1883451
pii:
doi:
Substances chimiques
Ant Venoms
0
Anthelmintics
0
Anti-Infective Agents
0
Hemolytic Agents
0
Insecticides
0
Peptides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
114693Subventions
Organisme : Intramural NIH HHS
ID : ZIA BC012003
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Références
J Biol Chem. 2018 Jun 8;293(23):9041-9052
pubmed: 29703751
Front Microbiol. 2020 May 28;11:1146
pubmed: 32670215
Prev Vet Med. 2020 Sep;182:105103
pubmed: 32750638
Amino Acids. 2011 Jan;40(1):69-76
pubmed: 20140690
Biol Chem. 2018 Jan 26;399(2):187-196
pubmed: 28976889
J Biol Chem. 2001 May 25;276(21):17823-9
pubmed: 11279030
Neurotoxicology. 2008 May;29(3):471-5
pubmed: 18423874
Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14243-8
pubmed: 23940362
Toxins (Basel). 2019 Jul 21;11(7):
pubmed: 31330893
Toxicon. 2018 Jun 15;148:172-196
pubmed: 29715467
Angew Chem Int Ed Engl. 2017 Jul 10;56(29):8495-8499
pubmed: 28513074
Sci Adv. 2018 Sep 12;4(9):eaau4640
pubmed: 30214940
Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3750-3755
pubmed: 28320941
Vet Parasitol. 1988 Jun;28(4):303-6
pubmed: 3420791
Bioconjug Chem. 2018 Oct 17;29(10):3309-3319
pubmed: 30148615
Biomedicines. 2020 Jun 30;8(7):
pubmed: 32629771
Parasit Vectors. 2019 Jun 17;12(1):306
pubmed: 31208455
Toxins (Basel). 2016 Jan 20;8(1):
pubmed: 26805882
Antibiotics (Basel). 2020 Jun 23;9(6):
pubmed: 32585881
Toxicon. 2014 Dec 15;92:166-78
pubmed: 25448389
Vet Parasitol. 2019 Jun;270:40-46
pubmed: 31213240
J Proteome Res. 2020 Apr 3;19(4):1800-1811
pubmed: 32182430
Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2553-2562
pubmed: 27474999
Biochemistry. 2008 May 20;47(20):5581-9
pubmed: 18426225
Int J Parasitol Drugs Drug Resist. 2020 Dec;14:8-16
pubmed: 32814269
Vet Parasitol. 2018 Jan 15;249:57-62
pubmed: 29279087
Biochim Biophys Acta Biomembr. 2017 May;1859(5):835-844
pubmed: 28115115
Vet Parasitol. 2012 May 4;186(1-2):70-8
pubmed: 22154968
Adv Parasitol. 2016;93:429-63
pubmed: 27238010
J Biol Chem. 2003 Oct 10;278(41):40050-6
pubmed: 12882967
Int J Parasitol Drugs Drug Resist. 2014 Aug 28;4(3):233-43
pubmed: 25516834
PLoS Negl Trop Dis. 2012 Jan;6(1):e1494
pubmed: 22303493
PLoS One. 2014 Jan 31;9(1):e87556
pubmed: 24498135
Toxicon. 2018 Aug;150:297-303
pubmed: 29920256
Proc Natl Acad Sci U S A. 2021 May 4;118(18):
pubmed: 33893140
Toxicon. 2008 Aug 1;52(2):264-76
pubmed: 18619481
Proc SPIE Int Soc Opt Eng. 2009 Aug 20;7397:
pubmed: 25593677
J Chem Ecol. 2015 Oct;41(10):884-95
pubmed: 26385230
Biochimie. 2014 Dec;107 Pt B:211-5
pubmed: 25220871
J Venom Anim Toxins Incl Trop Dis. 2018 Feb 17;24:6
pubmed: 29467797
Toxicon. 2017 Oct;137:168-172
pubmed: 28826757
Curr Biol. 2017 Apr 3;27(7):1013-1018
pubmed: 28343967
Parasitology. 2009 Aug;136(9):1065-80
pubmed: 19523255
Pept Sci (Hoboken). 2020 May;112(3):
pubmed: 33937618
Trends Ecol Evol. 2014 Nov;29(11):625-34
pubmed: 25278329
Cell Mol Life Sci. 2003 Dec;60(12):2651-68
pubmed: 14685689
Arch Biochem Biophys. 2005 Feb 15;434(2):358-64
pubmed: 15639237
Vet Parasitol. 2016 Apr 15;220:77-82
pubmed: 26995725
Toxicon. 2001 Feb-Mar;39(2-3):195-201
pubmed: 10978736
Peptides. 2012 Dec;38(2):363-70
pubmed: 22960382
ACS Pharmacol Transl Sci. 2020 Oct 06;3(6):1211-1224
pubmed: 33344898
Biochem Pharmacol. 2020 Nov;181:114096
pubmed: 32535105