The avian W chromosome is a refugium for endogenous retroviruses with likely effects on female-biased mutational load and genetic incompatibilities.


Journal

Philosophical transactions of the Royal Society of London. Series B, Biological sciences
ISSN: 1471-2970
Titre abrégé: Philos Trans R Soc Lond B Biol Sci
Pays: England
ID NLM: 7503623

Informations de publication

Date de publication:
13 09 2021
Historique:
entrez: 26 7 2021
pubmed: 27 7 2021
medline: 3 11 2021
Statut: ppublish

Résumé

It is a broadly observed pattern that the non-recombining regions of sex-limited chromosomes (Y and W) accumulate more repeats than the rest of the genome, even in species like birds with a low genome-wide repeat content. Here, we show that in birds with highly heteromorphic sex chromosomes, the W chromosome has a transposable element (TE) density of greater than 55% compared to the genome-wide density of less than 10%, and contains over half of all full-length (thus potentially active) endogenous retroviruses (ERVs) of the entire genome. Using RNA-seq and protein mass spectrometry data, we were able to detect signatures of female-specific ERV expression. We hypothesize that the avian W chromosome acts as a refugium for active ERVs, probably leading to female-biased mutational load that may influence female physiology similar to the 'toxic-Y' effect in

Identifiants

pubmed: 34304594
doi: 10.1098/rstb.2020.0186
pmc: PMC8310711
doi:

Banques de données

figshare
['10.6084/m9.figshare.c.5450746']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

20200186

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Auteurs

Valentina Peona (V)

Department of Organismal Biology-Systematic Biology, Uppsala University, Uppsala, Sweden.

Octavio M Palacios-Gimenez (OM)

Department of Organismal Biology-Systematic Biology, Uppsala University, Uppsala, Sweden.

Julie Blommaert (J)

Department of Organismal Biology-Systematic Biology, Uppsala University, Uppsala, Sweden.

Jing Liu (J)

MOE Laboratory of Biosystems Homeostasis and Protection, Life Sciences Institute, Zhejiang University, Hangzhou, People's Republic of China.
Department of Neuroscience and Development, University of Vienna, Vienna, Austria.

Tri Haryoko (T)

Museum Zoologicum Bogoriense, Research Centre for Biology, Indonesian Institute of Sciences (LIPI), Cibinong, Indonesia.

Knud A Jønsson (KA)

Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark.

Martin Irestedt (M)

Department of Bioinformatics and Genetics, Swedish Museum of Natural History, Stockholm, Sweden.

Qi Zhou (Q)

MOE Laboratory of Biosystems Homeostasis and Protection, Life Sciences Institute, Zhejiang University, Hangzhou, People's Republic of China.
Department of Neuroscience and Development, University of Vienna, Vienna, Austria.
Center for Reproductive Medicine, The 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310052, People's Republic of China.

Patric Jern (P)

Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

Alexander Suh (A)

Department of Organismal Biology-Systematic Biology, Uppsala University, Uppsala, Sweden.
School of Biological Sciences-Organisms and the Environment, University of East Anglia, Norwich, UK.

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