Progranulin deficiency in Iba-1
Animals
Calcium-Binding Proteins
Cells, Cultured
Choroidal Neovascularization
/ metabolism
Cytokines
/ metabolism
Disease Models, Animal
Inflammation
/ metabolism
Lysosomes
/ metabolism
Macrophages
/ metabolism
Macular Degeneration
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Microfilament Proteins
Myeloid Cells
/ metabolism
Neurons
/ metabolism
Progranulins
/ metabolism
Inflammation
Lysosome
Macrophage
Microglia
Neovascularization
Progranulin
Journal
Journal of neuroinflammation
ISSN: 1742-2094
Titre abrégé: J Neuroinflammation
Pays: England
ID NLM: 101222974
Informations de publication
Date de publication:
25 Jul 2021
25 Jul 2021
Historique:
received:
27
01
2021
accepted:
23
06
2021
entrez:
26
7
2021
pubmed:
27
7
2021
medline:
8
2
2022
Statut:
epublish
Résumé
Age-related macular degeneration (AMD) is the principal cause of permanent blindness among elderly individuals worldwide. Chronic inflammation in the subretinal space is associated with a progression of exudative AMD. Progranulin (PGRN) is a growth factor secreted from myeloid cells and plays an important role in controlling the lysosomal function. A deficiency in PGRN leads to inflammation of the neurons in the central nervous system. The purpose of this study was to investigate the role played by PGRN in the size of the choroidal neovascularization (CNV) in laser-induced CNV mice. CNVs were induced in C57BL/6J mice by laser photocoagulation of the retina. The expression of PGRN and the accumulation of Iba-1 Iba-1 These findings indicate that PGRN deficiency in Iba-1
Sections du résumé
BACKGROUND
BACKGROUND
Age-related macular degeneration (AMD) is the principal cause of permanent blindness among elderly individuals worldwide. Chronic inflammation in the subretinal space is associated with a progression of exudative AMD. Progranulin (PGRN) is a growth factor secreted from myeloid cells and plays an important role in controlling the lysosomal function. A deficiency in PGRN leads to inflammation of the neurons in the central nervous system. The purpose of this study was to investigate the role played by PGRN in the size of the choroidal neovascularization (CNV) in laser-induced CNV mice.
METHODS
METHODS
CNVs were induced in C57BL/6J mice by laser photocoagulation of the retina. The expression of PGRN and the accumulation of Iba-1
RESULTS
RESULTS
Iba-1
CONCLUSIONS
CONCLUSIONS
These findings indicate that PGRN deficiency in Iba-1
Identifiants
pubmed: 34304733
doi: 10.1186/s12974-021-02203-1
pii: 10.1186/s12974-021-02203-1
pmc: PMC8310601
doi:
Substances chimiques
Aif1 protein, mouse
0
Calcium-Binding Proteins
0
Cytokines
0
Microfilament Proteins
0
Progranulins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
164Informations de copyright
© 2021. The Author(s).
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