There is another: H3K27me3-mediated genomic imprinting.

Animals Chromatin / genetics DNA Methylation / genetics Genomic Imprinting / genetics Histone Code Histones / genetics Mice
DNA methylation H3K27me3 embryonic development evolutionary origin mouse noncanonical imprinting

Journal

Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085

Informations de publication

Date de publication:
01 2022
Historique:
received: 06 03 2021
revised: 25 06 2021
accepted: 28 06 2021
pubmed: 27 7 2021
medline: 11 3 2022
entrez: 26 7 2021
Statut: ppublish

Résumé

DNA methylation has long been considered the primary epigenetic mediator of genomic imprinting in mammals. Recent epigenetic profiling during early mouse development revealed the presence of domains of trimethylation of lysine 27 on histone H3 (H3K27me3) and chromatin compaction specifically at the maternally derived allele, independent of DNA methylation. Within these domains, genes are exclusively expressed from the paternally derived allele. This novel mechanism of noncanonical imprinting plays a key role in the development of mouse extraembryonic tissues and in the regulation of imprinted X-chromosome inactivation, highlighting the importance of parentally inherited epigenetic histone modifications. Here, we discuss the mechanisms underlying H3K27me3-mediated noncanonical imprinting in perspective of the dynamic chromatin landscape during early mouse development and explore evolutionary origins of noncanonical imprinting.

Identifiants

DOI: 10.1016/j.tig.2021.06.017 PMID: 34304914
pubmed: 34304914
pii: S0168-9525(21)00187-6
doi: 10.1016/j.tig.2021.06.017
pii:
doi:

Substances chimiques

Chromatin 0
Histones 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

82-96

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests No interests are declared.

Auteurs

Maximilian W D Raas (MWD)

Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University, 6525GA Nijmegen, The Netherlands.

Dick W Zijlmans (DW)

Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences (RIMLS), Oncode Institute, Radboud University, 6525GA Nijmegen, The Netherlands.

Michiel Vermeulen (M)

Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences (RIMLS), Oncode Institute, Radboud University, 6525GA Nijmegen, The Netherlands.

Hendrik Marks (H)

Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University, 6525GA Nijmegen, The Netherlands. Electronic address: Hendrik.Marks@ru.nl.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › There is another: H3K27me3-mediated genomic imprinting.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › There is another: H3K27me3-mediated genomic imprinting.
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › There is another: H3K27me3-mediated genomic imprinting.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Empreinte génomique › There is another: H3K27me3-mediated genomic imprinting.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Code histone › There is another: H3K27me3-mediated genomic imprinting.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › There is another: H3K27me3-mediated genomic imprinting.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › There is another: H3K27me3-mediated genomic imprinting.