The Medial Septum as a Potential Target for Treating Brain Disorders Associated With Oscillopathies.
Alzheimer’s disease
anxiety/fear
deep brain stimulation
depression
epilepsy
medial septum
oscillation
oscillopathy
Journal
Frontiers in neural circuits
ISSN: 1662-5110
Titre abrégé: Front Neural Circuits
Pays: Switzerland
ID NLM: 101477940
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
04
2021
accepted:
14
06
2021
entrez:
26
7
2021
pubmed:
27
7
2021
medline:
24
12
2021
Statut:
epublish
Résumé
The medial septum (MS), as part of the basal forebrain, supports many physiological functions, from sensorimotor integration to cognition. With often reciprocal connections with a broad set of peers at all major divisions of the brain, the MS orchestrates oscillatory neuronal activities throughout the brain. These oscillations are critical in generating sensory and emotional salience, locomotion, maintaining mood, supporting innate anxiety, and governing learning and memory. Accumulating evidence points out that the physiological oscillations under septal influence are frequently disrupted or altered in pathological conditions. Therefore, the MS may be a potential target for treating neurological and psychiatric disorders with abnormal oscillations (oscillopathies) to restore healthy patterns or erase undesired ones. Recent studies have revealed that the patterned stimulation of the MS alleviates symptoms of epilepsy. We discuss here that stimulus timing is a critical determinant of treatment efficacy on multiple time scales. On-demand stimulation may dramatically reduce side effects by not interfering with normal physiological functions. A precise pattern-matched stimulation through adaptive timing governed by the ongoing oscillations is essential to effectively terminate pathological oscillations. The time-targeted strategy for the MS stimulation may provide an effective way of treating multiple disorders including Alzheimer's disease, anxiety/fear, schizophrenia, and depression, as well as pain.
Identifiants
pubmed: 34305537
doi: 10.3389/fncir.2021.701080
pmc: PMC8297467
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
701080Informations de copyright
Copyright © 2021 Takeuchi, Nagy, Barcsai, Li, Ohsawa, Mizuseki and Berényi.
Déclaration de conflit d'intérêts
AB and AJN are the owner of Amplipex Llc. and a shareholder of Neunos Ltd., Szeged, Hungary, manufacturers of signal-multiplexed neuronal amplifiers and neurostimulator devices. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Neurobiol Learn Mem. 2018 Jul;152:71-79
pubmed: 29783059
Trends Neurosci. 2018 Jul;41(7):418-428
pubmed: 29735372
Hippocampus. 2015 Oct;25(10):1073-188
pubmed: 26135716
BMC Neurosci. 2017 Mar 7;18(1):29
pubmed: 28264667
Nat Rev Neurosci. 2008 Mar;9(3):182-94
pubmed: 18270514
Physiol Behav. 1992 Feb;51(2):391-4
pubmed: 1313592
Synapse. 2005 Dec 1;58(3):151-64
pubmed: 16108008
Brain Res. 2004 Mar 19;1001(1-2):60-71
pubmed: 14972654
Neurobiol Learn Mem. 2016 Sep;133:39-52
pubmed: 27264248
Neuroscience. 1997 May;78(2):399-410
pubmed: 9145797
J Comp Neurol. 1993 Mar 22;329(4):438-57
pubmed: 8454735
Neurology. 2011 Sep 27;77(13):1295-304
pubmed: 21917777
World Neurosurg. 2013 Dec;80(6):e245-53
pubmed: 23044000
J Physiol. 2003 Sep 15;551(Pt 3):927-43
pubmed: 12865506
J Comp Neurol. 1986 Jan 22;243(4):488-509
pubmed: 3512629
J Neural Transm (Vienna). 2016 Jul;123(7):775-783
pubmed: 26443701
Elife. 2017 Apr 03;6:
pubmed: 28368242
Brain Res. 1989 Feb 13;479(2):225-40
pubmed: 2924157
Clin Neurophysiol. 2017 Mar;128(3):424-432
pubmed: 28160748
Electroencephalogr Clin Neurophysiol. 1962 Apr;14:202-11
pubmed: 14038334
Nat Rev Neurosci. 2006 Aug;7(8):663-78
pubmed: 16858394
Mol Psychiatry. 2020 Oct 22;:
pubmed: 33093652
Nat Commun. 2020 May 18;11(1):2469
pubmed: 32424312
J Neurosci. 1999 Jul 15;19(14):6191-9
pubmed: 10407055
Neuroscience. 1986 Feb;17(2):439-51
pubmed: 3517690
Exp Neurol. 2010 Mar;222(1):86-92
pubmed: 20026111
Neurosci Lett. 2009 Mar 20;452(3):247-51
pubmed: 19150485
J Comp Neurol. 1989 Dec 8;290(2):213-42
pubmed: 2592611
Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13535-40
pubmed: 25197052
Hippocampus. 2015 Aug;25(8):924-38
pubmed: 25601003
J Neurosurg. 2013 Dec;119(6):1546-55
pubmed: 24074498
Physiol Behav. 1996 Sep;60(3):845-53
pubmed: 8873261
Cell Rep. 2018 Mar 20;22(12):3328-3338
pubmed: 29562187
Front Synaptic Neurosci. 2013 Jul 30;5:2
pubmed: 23908628
J Comp Neurol. 1979 Feb 15;183(4):689-706
pubmed: 105019
Neuroscience. 1997 Apr;77(3):713-21
pubmed: 9070747
J Comp Neurol. 1989 Nov 8;289(2):304-14
pubmed: 2808769
Nat Neurosci. 2014 Jan;17(1):106-13
pubmed: 24241397
Science. 2011 Apr 29;332(6029):592-5
pubmed: 21527713
Sci Rep. 2020 Jan 29;10(1):1407
pubmed: 31996750
Biol Psychiatry. 2008 Jun 1;63(11):1075-83
pubmed: 18261715
Neuroscience. 2011 Sep 29;192:91-101
pubmed: 21736924
J Neurosci. 1987 Dec;7(12):4159-64
pubmed: 3694268
Behav Brain Res. 2014 Jun 1;266:174-82
pubmed: 24632470
J Comp Neurol. 1979 Aug 15;186(4):621-55
pubmed: 15116692
Brain Res. 1990 Sep 24;528(1):12-20
pubmed: 2245328
Neuron. 2014 Oct 22;84(2):470-85
pubmed: 25263753
Biomed Res Int. 2014;2014:568587
pubmed: 25101288
J Physiol. 2008 Aug 15;586(16):3893-915
pubmed: 18565991
J Neurosci. 1994 Nov;14(11 Pt 2):7040-52
pubmed: 7965097
Cell Tissue Res. 2018 Sep;373(3):565-575
pubmed: 29250747
Hippocampus. 2011 Dec;21(12):1277-89
pubmed: 20623740
J Neurosci. 2011 Aug 10;31(32):11733-43
pubmed: 21832203
Behav Brain Res. 2017 Feb 15;319:73-86
pubmed: 27845230
J Comp Neurol. 1991 Jun 8;308(2):249-76
pubmed: 1716270
Exp Neurol. 2013 Sep;247:419-28
pubmed: 23376225
Trends Neurosci. 2019 Mar;42(3):205-220
pubmed: 30621912
Nature. 2020 Oct;586(7827):87-94
pubmed: 32939091
Nat Rev Neurol. 2021 Feb;17(2):75-87
pubmed: 33244188
Neurol Med Chir (Tokyo). 2010;50(9):845-52
pubmed: 20885119
J Neurosci. 2009 Jun 24;29(25):8094-102
pubmed: 19553449
Brain Stimul. 2019 May - Jun;12(3):735-742
pubmed: 30733144
Cell Tissue Res. 1985;239(2):253-70
pubmed: 2579738
Epilepsia. 2018 Feb;59(2):273-290
pubmed: 29218702
J Neurophysiol. 2006 Jun;95(6):3645-53
pubmed: 16554504
Dis Markers. 2018 Oct 4;2018:5174815
pubmed: 30405860
Brain Res. 1982 Aug 19;246(1):77-87
pubmed: 6289975
Epilepsy Res. 1994 Jul;18(3):195-204
pubmed: 7805641
Science. 2021 Apr 2;372(6537):
pubmed: 33795429
Brain. 2021 Jun 22;144(5):1576-1589
pubmed: 33769452
Ann Neurol. 2010 Oct;68(4):521-34
pubmed: 20687206
Science. 2012 Aug 10;337(6095):735-7
pubmed: 22879515
Nat Rev Neurosci. 2010 Feb;11(2):100-13
pubmed: 20087360
Neurosci Lett. 2018 Apr 3;671:7-12
pubmed: 29410218
Pain. 2011 Nov;152(11):2528-2542
pubmed: 21903328
J Comp Neurol. 1976 May 15;167(2):227-56
pubmed: 819466
Sci Rep. 2021 Jan 22;11(1):2117
pubmed: 33483520
Brain Res Brain Res Rev. 1997 Sep 19;24(2-3):91-113
pubmed: 9385453
Sci Rep. 2017 Nov 6;7(1):14573
pubmed: 29109512
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10825-30
pubmed: 12149439
Behav Brain Res. 2000 Nov;115(2):117-41
pubmed: 11000416
Neuroreport. 2010 Feb 17;21(3):179-84
pubmed: 20042896
Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1886-E1895
pubmed: 29437952
Epilepsy Curr. 2016 Jan-Feb;16(1):48-61
pubmed: 26900382
Curr Opin Neurobiol. 1993 Dec;3(6):917-24
pubmed: 8124075
Transl Psychiatry. 2018 Sep 4;8(1):177
pubmed: 30181587
Brain Res. 1989 Jan 30;478(2):375-81
pubmed: 2924136
Neuroscience. 1989;28(3):585-610
pubmed: 2710333
Neurobiol Dis. 2019 Oct;130:104488
pubmed: 31181283
Front Psychiatry. 2020 Jun 30;11:613
pubmed: 32719622
J Neurosci. 2004 Sep 29;24(39):8470-9
pubmed: 15456820
J Neurosci. 1996 Dec 1;16(23):7699-710
pubmed: 8922426
Behav Brain Res. 2013 Jun 15;247:193-200
pubmed: 23542088
JAMA Neurol. 2018 Mar 1;75(3):279-286
pubmed: 29279892
J Neurotrauma. 2015 Nov 15;32(22):1822-32
pubmed: 26096267
Philos Trans R Soc Lond B Biol Sci. 2013 Dec 23;369(1635):20130304
pubmed: 24366145
Neuropsychopharmacology. 2018 Sep;43(10):2093-2100
pubmed: 29654260
J Physiol. 2005 Aug 1;566(Pt 3):865-84
pubmed: 15919710
Neuroendocrinology. 1987 Jan;45(1):77-85
pubmed: 3808223
J Physiol. 2004 Dec 15;561(Pt 3):657-70
pubmed: 15486020
Neuron. 2020 Aug 19;107(4):731-744.e3
pubmed: 32526196
Neuron. 2002 Jan 31;33(3):325-40
pubmed: 11832222
Electroencephalogr Clin Neurophysiol. 1969 Apr;26(4):407-18
pubmed: 4183562
Nature. 2013 May 2;497(7447):74-9
pubmed: 23594744
J Neurosci. 2009 Dec 9;29(49):15375-85
pubmed: 20007462
Front Neuroanat. 2017 Dec 12;11:120
pubmed: 29311851
J Neurosci. 1996 Sep 1;16(17):5547-54
pubmed: 8757266
Brain Res Bull. 1986 May;16(5):603-37
pubmed: 3742247
Front Neuroanat. 2018 Jan 17;11:133
pubmed: 29403361
Behav Brain Res. 2000 Jun 15;111(1-2):1-11
pubmed: 10840127
Neurosci Lett. 2017 Jan 18;638:139-144
pubmed: 27939976
Neurosurgery. 1979 Aug;5(2):277-83
pubmed: 113691
Nat Neurosci. 2013 Sep;16(9):1182-4
pubmed: 23912949
Brain Res. 1991 Dec 6;566(1-2):115-26
pubmed: 1814530
Exp Neurol. 1976 Apr;51(1):78-109
pubmed: 1261644
Cell Tissue Res. 1978 Jul 10;190(3):383-407
pubmed: 688339
Brain Stimul. 2020 Nov - Dec;13(6):1535-1547
pubmed: 32871261
Brain Struct Funct. 2020 Apr;225(3):935-954
pubmed: 32107637
Brain. 2018 Jul 1;141(7):1917-1933
pubmed: 29850777
Neuroscience. 1978;3(6):539-50
pubmed: 151244
Nat Neurosci. 2012 Nov;15(11):1524-30
pubmed: 23042082
Neuron. 2017 Mar 8;93(5):1213-1226.e5
pubmed: 28279355
J Comp Neurol. 1996 Aug 19;372(2):204-14
pubmed: 8863126
Am J Psychiatry. 1958 Nov;115(5):459-64
pubmed: 13583250
Nature. 2005 Aug 11;436(7052):801-6
pubmed: 15965463
Brain Res. 2011 Mar 25;1382:189-97
pubmed: 21295558
Synapse. 1987;1(5):455-60
pubmed: 3505373
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23242-23251
pubmed: 32503914
Neurology. 1984 Jun;34(6):741-5
pubmed: 6539435
Curr Biol. 2018 Apr 23;28(8):1179-1188.e3
pubmed: 29628373
J Neurosci. 2012 Jan 11;32(2):423-35
pubmed: 22238079
Behav Brain Res. 2012 Jul 15;233(1):224-31
pubmed: 22579972
J Comp Neurol. 1974 Jul;156(2):179-205
pubmed: 4419253
Hippocampus. 2005;15(3):381-92
pubmed: 15630696
Neuroscience. 1995 Aug;67(3):679-88
pubmed: 7675194
J Comp Neurol. 2015 Mar 1;523(4):565-88
pubmed: 25269409
Curr Opin Neurobiol. 2011 Jun;21(3):452-9
pubmed: 21371881
Am J Psychiatry. 1991 Nov;148(11):1474-86
pubmed: 1681750
Behav Brain Res. 2004 Nov 5;155(1):153-66
pubmed: 15325789
Exp Neurol. 2013 Sep;247:314-27
pubmed: 23384663
Sci Rep. 2017 Oct 27;7(1):14189
pubmed: 29079799
Sci Rep. 2016 Oct 05;6:34800
pubmed: 27703268
Brain Struct Funct. 2019 Jan;224(1):363-372
pubmed: 30341742
Behav Brain Res. 2010 Jun 26;210(1):67-73
pubmed: 20153380
Neuropsychopharmacology. 2003 May;28(5):857-64
pubmed: 12637957
Epilepsy Res. 2017 Feb;130:53-63
pubmed: 28152425
Mol Psychiatry. 2015 Mar;20(3):353-60
pubmed: 24798585
Neurosci Behav Physiol. 2009 Sep;39(7):619-23
pubmed: 19621263
Epilepsy Res Treat. 2013;2013:932790
pubmed: 23853720
Neuron. 2016 Aug 3;91(3):666-79
pubmed: 27427460
J Neurochem. 2006 Feb;96(3):609-23
pubmed: 16405497
Front Behav Neurosci. 2014 Mar 18;8:92
pubmed: 24672455
J Comp Neurol. 1985 Dec 1;242(1):1-27
pubmed: 3841131
J Comp Neurol. 1986 Jan 1;243(1):58-70
pubmed: 2419367
Eur J Neurosci. 2005 Mar;21(6):1659-70
pubmed: 15845093
Neuron. 2018 Sep 5;99(5):1016-1028.e5
pubmed: 30122379
Nat Rev Neurol. 2018 Oct;14(10):618-630
pubmed: 30131521
Brain Res Brain Res Rev. 2003 Jan;41(1):57-78
pubmed: 12505648
Neuron. 2018 Jan 3;97(1):14-31
pubmed: 29301099
Nature. 2017 Mar 29;543(7647):719-722
pubmed: 28358077
Eur J Neurosci. 2004 Apr;19(8):2299-309
pubmed: 15090056
Physiol Behav. 1996 Apr-May;59(4-5):887-95
pubmed: 8778883
Eur J Neurosci. 1998 Feb;10(2):464-77
pubmed: 9749709
Hippocampus. 1994 Dec;4(6):649-60
pubmed: 7704109
J Neurosci. 2010 Aug 18;30(33):10991-1003
pubmed: 20720106
Hippocampus. 2021 Feb;31(2):213-220
pubmed: 33263940
J Neurophysiol. 2002 Feb;87(2):889-900
pubmed: 11826054
J Neurosci. 1995 Jan;15(1 Pt 1):47-60
pubmed: 7823151
J Comp Neurol. 2003 Mar 24;458(1):11-31
pubmed: 12577320
Neuron. 2005 Mar 3;45(5):651-60
pubmed: 15748841
Neurosci Biobehav Rev. 1992 Fall;16(3):289-308
pubmed: 1528522
Physiol Rev. 1995 Apr;75(2):393-427
pubmed: 7724668
Brain Res Bull. 1982 Jul-Dec;9(1-6):321-53
pubmed: 6816390
Nat Rev Neurosci. 2016 Apr;17(4):239-49
pubmed: 26961163
J Neuroendocrinol. 1998 Sep;10(9):687-92
pubmed: 9744486
Exp Neurol. 2009 Apr;216(2):449-58
pubmed: 19168062
Hippocampus. 2011 Aug;21(8):835-46
pubmed: 20865731
J Nerv Ment Dis. 1972 Jan;154(1):3-18
pubmed: 5007439
Eur J Neurosci. 2013 Jun;37(12):1896-902
pubmed: 23773058
Brain Res. 1985 Feb 25;328(1):15-21
pubmed: 3971172
NPJ Schizophr. 2018 Sep 3;4(1):17
pubmed: 30177811
Brain Struct Funct. 2017 Aug;222(6):2727-2742
pubmed: 28161726
J Comp Neurol. 2001 Sep 10;438(1):86-122
pubmed: 11503154
Front Syst Neurosci. 2017 Jun 30;11:48
pubmed: 28713250
Life Sci. 2011 Nov 21;89(21-22):821-6
pubmed: 21983416
Brain Res. 1993 Sep 10;621(2):272-8
pubmed: 7694764
Sci Rep. 2017 Jul 24;7(1):6300
pubmed: 28740261
Z Zellforsch Mikrosk Anat. 1965 Feb 9;65:573-96
pubmed: 14263017
Lancet. 1998 Aug 22;352(9128):620-1
pubmed: 9746027
Brain. 2021 Apr 12;144(3):885-908
pubmed: 33501929
Neuron. 2010 Jan 28;65(2):257-69
pubmed: 20152131
J Neurol Sci. 1967 Jul-Aug;5(1):115-20
pubmed: 6061755
Epilepsia. 2016 Jun;57(6):977-83
pubmed: 27030321
J Comp Neurol. 1999 Aug 9;410(4):586-98
pubmed: 10398050
J Comp Physiol Psychol. 1954 Dec;47(6):419-27
pubmed: 13233369
Ann N Y Acad Sci. 2012 Aug;1265:25-35
pubmed: 22823464
J Neurophysiol. 1982 Oct;48(4):981-9
pubmed: 7143037
J Clin Psychiatry. 2015 Feb;76(2):155-62
pubmed: 25742202
J Neurosci. 2020 Aug 12;40(33):6398-6408
pubmed: 32661022
Learn Mem. 2007 Dec 17;14(12):833-41
pubmed: 18086826
Sci Rep. 2019 Dec 5;9(1):18447
pubmed: 31804517
Psychopharmacology (Berl). 2009 Oct;206(3):457-67
pubmed: 19655127
Nat Commun. 2018 Jul 20;9(1):2848
pubmed: 30030438
J Neurosci. 2019 Jun 26;39(26):5234-5242
pubmed: 31028115
Brain Res. 1977 Jan 1;119(1):1-20
pubmed: 63306
J Neurosci. 2007 Aug 15;27(33):8790-804
pubmed: 17699661
Nat Rev Neurosci. 2007 Aug;8(8):623-35
pubmed: 17637800
Pain. 2018 Aug;159(8):1550-1561
pubmed: 29624516
Nature. 2017 Nov 22;551(7682):549-550
pubmed: 29189789
Cell Rep. 2014 Apr 10;7(1):269-80
pubmed: 24656815
Hippocampus. 1993 Jul;3(3):317-30
pubmed: 8353611
J Neurochem. 2018 Mar;144(5):669-679
pubmed: 28777881
J Neurosci. 2016 Apr 13;36(15):4155-69
pubmed: 27076416
J Neurosci. 1993 Sep;13(9):3712-24
pubmed: 7690065
Brain Res. 2012 Jun 21;1461:1-9
pubmed: 22608077
Nat Commun. 2019 Nov 22;10(1):5322
pubmed: 31757962
J Hist Neurosci. 2000 Dec;9(3):262-78
pubmed: 11232368
JAMA Psychiatry. 2015 Aug;72(8):840-4
pubmed: 26039190
Neuroscience. 1998 Jul;85(1):149-78
pubmed: 9607710
Science. 2008 Jul 4;321(5885):53-7
pubmed: 18599766
Nat Neurosci. 2015 Feb;18(2):282-8
pubmed: 25531571
Neuroscience. 2000;97(4):657-69
pubmed: 10842010
J Clin Neurosci. 2005 Jun;12(5):515-9
pubmed: 15993077
Science. 2017 Oct 27;358(6362):482-485
pubmed: 29074768
Hum Neurobiol. 1982;1(4):261-72
pubmed: 7185796
Neurosurgery. 2014 Aug;61 Suppl 1:175-81
pubmed: 25032548
Neuron. 2016 Jul 6;91(1):34-40
pubmed: 27387648
Sci Rep. 2015 Oct 21;5:15419
pubmed: 26487082
Hippocampus. 2011 Sep;21(9):1021-7
pubmed: 20842629
Brain Res. 1983 Sep 5;274(1):156-9
pubmed: 6412965
Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):E2644-E2652
pubmed: 29487212
Front Syst Neurosci. 2017 Sep 20;11:67
pubmed: 28979196
Behav Brain Res. 2003 Feb 17;139(1-2):197-213
pubmed: 12642189
Nat Neurosci. 2009 Dec;12(12):1491-3
pubmed: 19881503
Brain Res. 2009 Jan 28;1251:185-94
pubmed: 19061870
Hippocampus. 1993 Oct;3(4):517-25
pubmed: 8269041
Sci Rep. 2018 Aug 8;8(1):11892
pubmed: 30089875
Neurobiol Learn Mem. 2017 Feb;138:238-251
pubmed: 27444843
Neurosci Res. 2005 May;52(1):107-19
pubmed: 15811558
J Comp Neurol. 2003 Sep 8;464(1):62-97
pubmed: 12866129
Can J Neurol Sci. 2009 Aug;36 Suppl 2:S33-5
pubmed: 19760897
Annu Rev Neurosci. 2012;35:203-25
pubmed: 22443509
Exp Brain Res. 1989;75(2):401-16
pubmed: 2721618
Prog Neurobiol. 1986;26(1):1-54
pubmed: 2870537
Science. 1996 Jun 7;272(5267):1484-6
pubmed: 8633241
Electroencephalogr Clin Neurophysiol. 1972 Mar;32(3):281-94
pubmed: 4110397
Neurosci Biobehav Rev. 1985 Winter;9(4):573-87
pubmed: 2417173
Prog Neurobiol. 2012 Sep;98(3):241-9
pubmed: 22449727
J Comp Neurol. 1988 Nov 8;277(2):281-301
pubmed: 2466060
Science. 2016 May 13;352(6287):812-6
pubmed: 27174984
Nat Neurosci. 2017 Jan;20(1):16-19
pubmed: 27893726
Nat Commun. 2020 Jan 14;11(1):262
pubmed: 31937768
Parkinsonism Relat Disord. 2013 Jul;19(7):676-9
pubmed: 23582712
Front Pharmacol. 2020 Oct 16;11:486811
pubmed: 33178010
Trends Neurosci. 2020 Jan;43(1):24-41
pubmed: 31836315
Nat Commun. 2015 Oct 12;6:8521
pubmed: 26455912
Neurobiol Aging. 2020 Oct;94:121-129
pubmed: 32619873
Neurobiol Aging. 2010 Jan;31(1):46-57
pubmed: 18547680
J Comp Neurol. 1988 Jan 15;267(3):433-53
pubmed: 2449477
Epilepsia. 2012 May;53(5):817-24
pubmed: 22429112
Cold Spring Harb Perspect Med. 2015 Sep 18;5(10):
pubmed: 26385090
Brain. 2014 Aug;137(Pt 8):2210-30
pubmed: 24919973
Neurosci Res. 2020 Mar;152:87-107
pubmed: 31954733
Neuroscience. 2001;103(4):985-98
pubmed: 11301206
Front Aging Neurosci. 2017 Sep 20;9:304
pubmed: 29081745
Brain Res Bull. 1984 Dec;13(6):751-84
pubmed: 6532518
CNS Neurosci Ther. 2021 May;27(5):577-586
pubmed: 33502829
J Comp Neurol. 1985 Sep 8;239(2):237-46
pubmed: 4044938
Neurosurg Clin N Am. 2003 Jul;14(3):389-99, vi
pubmed: 14567140
Pharmacol Biochem Behav. 2003 May;75(2):491-6
pubmed: 12873642
Trends Cogn Sci. 2010 Nov;14(11):506-15
pubmed: 20932795
Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20942-7
pubmed: 19934062
Acta Neurochir Suppl (Wien). 1993;58:154-5
pubmed: 8109280
Nat Biotechnol. 2018 Nov;36(10):954-961
pubmed: 30199076
Hippocampus. 2012 Dec;22(12):2208-18
pubmed: 22592894
J Neurosci. 2016 Nov 2;36(44):11185-11195
pubmed: 27807162
Brain Res Bull. 2020 Aug;161:166-176
pubmed: 32473192
J Comp Neurol. 1984 May 20;225(3):327-43
pubmed: 6725648
J Neurosci. 2002 Jan 15;22(2):RC200
pubmed: 11784812
Neuroreport. 1991 Nov;2(11):723-5
pubmed: 1810464
Schizophr Bull. 2008 Sep;34(5):974-80
pubmed: 18559405
Sci Adv. 2020 Oct 30;6(44):
pubmed: 33127668
Science. 1963 Apr 26;140(3565):394-6
pubmed: 13971228
Psychopharmacology (Berl). 2019 Jan;236(1):321-338
pubmed: 30417233
Biol Psychiatry. 2020 May 1;87(9):843-856
pubmed: 31987494
Adv Exp Med Biol. 2020;1191:331-346
pubmed: 32002936
Brain Res. 1992 Jun 26;583(1-2):1-11
pubmed: 1380395
Sci Rep. 2021 Jan 13;11(1):1099
pubmed: 33441788
J Neurosci. 2010 Nov 24;30(47):15951-61
pubmed: 21106833
Arch Gen Psychiatry. 1994 Mar;51(3):199-214
pubmed: 8122957
J Neurosci. 1982 Mar;2(3):292-302
pubmed: 7062110
Nature. 2009 Nov 19;462(7271):353-7
pubmed: 19924214
J Neurosci. 2015 Dec 2;35(48):15812-26
pubmed: 26631464
J Alzheimers Dis. 2014;38(4):867-79
pubmed: 24081376
Epilepsia. 2014 Apr;55(4):475-82
pubmed: 24730690
Behav Neurosci. 2004 Oct;118(5):1033-41
pubmed: 15506885
Mol Psychiatry. 2018 May;23(5):1094-1112
pubmed: 29483673
J Comp Neurol. 1990 Mar 1;293(1):103-24
pubmed: 2312788
Schizophr Bull. 2012 Sep;38(5):950-7
pubmed: 22355184
Med Hypotheses. 2015 Jun;84(6):543-50
pubmed: 25771138
Brain Res Brain Res Rev. 1997 Sep 19;24(2-3):115-95
pubmed: 9385454
Learn Mem. 2009 Oct 30;16(11):730-42
pubmed: 19880588
Hippocampus. 1996;6(4):347-470
pubmed: 8915675
Pharmacol Biochem Behav. 2001 Jul-Aug;69(3-4):391-9
pubmed: 11509196
Nature. 1988 Nov 10;336(6195):170-3
pubmed: 3185735
Nat Rev Neurol. 2014 May;10(5):271-82
pubmed: 24752120
Neuropharmacology. 2012 Sep;63(4):507-13
pubmed: 22569197
PLoS One. 2018 Nov 5;13(11):e0206532
pubmed: 30395575
N Engl J Med. 2011 Sep 8;365(10):919-26
pubmed: 21899452
Neuroscience. 1991;41(2-3):381-90
pubmed: 1714548
Neuron. 2015 Jun 3;86(5):1253-64
pubmed: 25982367
Neurosci Biobehav Rev. 2018 Feb;85:65-80
pubmed: 28887226
J Neurosci. 2016 Mar 9;36(10):3016-23
pubmed: 26961955
Physiol Behav. 1984 Oct;33(4):621-6
pubmed: 6522481
Brain Stimul. 2008 Apr;1(2):112-21
pubmed: 20633378