Exposure to Perfluoroalkyl Chemicals and Cardiovascular Disease: Experimental and Epidemiological Evidence.
arterial hypertension
cardiovascular disease
diabetes mellitus
obesity
perfluoroalkyl substances
platelets
thrombosis
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2021
2021
Historique:
received:
07
05
2021
accepted:
28
06
2021
entrez:
26
7
2021
pubmed:
27
7
2021
medline:
12
2
2022
Statut:
epublish
Résumé
Polyfluoro- and perfluoro-alkyl substances (PFAS) are organic chemicals extensively used worldwide for industry and consumer products. Due to their chemical stability, PFAS represent a major cause of environmental pollution. PFAS accumulate in animal and human blood and tissues exerting their toxicity. We performed a review of the epidemiological studies exploring the relationship between exposure to PFAS and thromboembolic cardiovascular disease. An increase in cardiovascular disease or death related to PFAS exposure has been reported from cross-sectional and longitudinal observational studies with evidence concerning the relation with early vascular lesions and atherosclerosis. Several studies indicate an alteration in lipid and glucose metabolism disorders and increased blood pressure as a possible link with cardiovascular thromboembolic events. We also examined the recent evidence indicating that legacy and new PFAS can be incorporated in platelet cell membranes giving a solid rationale to the observed increase risk of cardiovascular events in the populations exposed to PFAS by directly promoting thrombus formation. Exposure to PFAS has been related to altered plasma membrane fluidity and associated with altered calcium signal and increased platelet response to agonists, both
Identifiants
pubmed: 34305819
doi: 10.3389/fendo.2021.706352
pmc: PMC8298860
doi:
Substances chimiques
Environmental Pollutants
0
Fluorocarbons
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
706352Informations de copyright
Copyright © 2021 Meneguzzi, Fava, Castelli and Minuz.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Sci Total Environ. 2019 Sep 15;683:29-36
pubmed: 31129329
Environ Int. 2017 Dec;109:128-135
pubmed: 28890218
Eur J Public Health. 2018 Feb 1;28(1):180-185
pubmed: 28541558
Environ Int. 2018 Oct;119:37-46
pubmed: 29933236
Ann Epidemiol. 2008 Jan;18(1):15-22
pubmed: 17900928
Int J Cardiol. 2013 Oct 9;168(4):3309-16
pubmed: 23664439
Environ Health Perspect. 2017 Mar;125(3):481-487
pubmed: 27586368
Environ Health. 2020 Sep 21;19(1):102
pubmed: 32958007
Int J Environ Res Public Health. 2021 Jan 29;18(3):
pubmed: 33572770
Environ Int. 2019 May;126:445-453
pubmed: 30844580
Environ Int. 2018 Jul;116:101-107
pubmed: 29660612
Front Cardiovasc Med. 2018 Apr 04;5:29
pubmed: 29670887
Front Cardiovasc Med. 2017 Nov 21;4:74
pubmed: 29209618
Int J Hyg Environ Health. 2018 Aug;221(7):1054-1060
pubmed: 30056006
Environ Health Perspect. 2009 Dec;117(12):1873-82
pubmed: 20049206
Environ Health. 2020 Mar 14;19(1):33
pubmed: 32169067
Environ Sci Pollut Res Int. 2017 Oct;24(30):23436-23440
pubmed: 28913736
Environ Int. 2016 May;91:312-8
pubmed: 27003842
Environ Res. 2019 Dec;179(Pt A):108743
pubmed: 31542491
Environ Int. 2019 Jun;127:85-93
pubmed: 30909097
Sci Total Environ. 2018 Apr 15;621:1542-1549
pubmed: 29054655
Ann Med. 2019 May - Jun;51(3-4):193-223
pubmed: 31007084
Environ Sci Technol. 2017 Feb 21;51(4):2047-2057
pubmed: 28098989
Int J Hyg Environ Health. 2021 Jun;235:113754
pubmed: 33984600
Occup Environ Med. 2012 Sep;69(9):658-62
pubmed: 22652006
Environ Int. 2015 Feb;75:172-9
pubmed: 25461427
Fertil Steril. 2015 Jan;103(1):184-9
pubmed: 25450302
Environ Sci Technol. 2011 Oct 1;45(19):7954-61
pubmed: 21866930
Environ Health Perspect. 2018 Mar 01;126(3):037001
pubmed: 29498927
Environ Int. 2019 Mar;124:58-65
pubmed: 30639908
Environ Health. 2018 Jul 3;17(1):59
pubmed: 29970113
Environ Pollut. 2019 Nov;254(Pt A):112971
pubmed: 31394346
J Diabetes Complications. 2016 Aug;30(6):993-8
pubmed: 27311784
Environ Int. 2021 Sep;154:106584
pubmed: 33895438
Environ Health Perspect. 2007 Sep;115(9):1298-305
pubmed: 17805419
Environ Int. 2019 Aug;129:343-353
pubmed: 31150976
Environ Res. 2009 Nov;109(8):997-1003
pubmed: 19740462
Environ Int. 2020 Dec;145:106095
pubmed: 32919259
Nat Rev Cardiol. 2019 Mar;16(3):166-179
pubmed: 30429532
Environ Res. 2013 Nov;127:22-8
pubmed: 24199934
Ecotoxicol Environ Saf. 2020 Jun 15;196:110589
pubmed: 32278136
Arch Environ Contam Toxicol. 2021 Jul;81(1):133-141
pubmed: 34037834
Environ Int. 2018 Jun;115:295-300
pubmed: 29621717
J Lipid Atheroscler. 2020 Sep;9(3):334-348
pubmed: 33024729
Environ Health Perspect. 2007 Nov;115(11):1596-602
pubmed: 18007991
Environ Health Perspect. 2017 Nov 13;125(11):117004
pubmed: 29135438
Environ Int. 2020 Dec;145:106117
pubmed: 32971418
J Thromb Haemost. 2015 Jun;13 Suppl 1:S40-6
pubmed: 26149049
Environ Pollut. 2018 Jan;232:73-79
pubmed: 28923343
Environ Res. 2013 Feb;121:95-103
pubmed: 23266098
PLoS Med. 2018 Feb 13;15(2):e1002502
pubmed: 29438414
Diabetes Care. 2019 Sep;42(9):1824-1832
pubmed: 31296647
Environ Int. 2018 May;114:12-20
pubmed: 29459131
Environ Health Perspect. 2010 Feb;118(2):197-202
pubmed: 20123614
Int J Mol Sci. 2020 Jan 08;21(2):
pubmed: 31936344
Arch Intern Med. 2012 Oct 8;172(18):1397-403
pubmed: 22945282
Int J Mol Sci. 2021 Jan 20;22(3):
pubmed: 33498193
J Endocrinol Invest. 2020 May;43(5):641-652
pubmed: 31776969
J Clin Endocrinol Metab. 2021 Jul 13;106(8):2495-2504
pubmed: 33890111
Am J Epidemiol. 2009 Nov 15;170(10):1268-78
pubmed: 19846564
Trends Biochem Sci. 2014 Mar;39(3):130-40
pubmed: 24534649
Diab Vasc Dis Res. 2020 Jan-Feb;17(1):1479164119892223
pubmed: 31841043
Lancet Diabetes Endocrinol. 2020 Aug;8(8):703-718
pubmed: 32707118
Thromb Haemost. 2010 Sep;104(3):456-63
pubmed: 20664896
Environ Health Perspect. 2014 Dec;122(12):1299-305
pubmed: 25260175
Environ Health Perspect. 2017 Oct 02;125(10):107001
pubmed: 28974480
Epidemiology. 2009 Nov;20(6):921-8
pubmed: 19797969
JAMA Netw Open. 2018 Aug 3;1(4):e181493
pubmed: 30646133
FASEB J. 2018 Jul;32(7):3912-3923
pubmed: 29481306
Environ Res. 2015 Oct;142:148-54
pubmed: 26142720
Chemosphere. 2020 Dec;261:127691
pubmed: 32717511
Environ Int. 2016 Sep;94:292-299
pubmed: 27288966
Sci Total Environ. 2018 Jun 1;625:566-574
pubmed: 29291571
J Thromb Haemost. 2010 Nov;8(11):2358-68
pubmed: 20695980
Diabetes Care. 2016 Oct;39(10):1745-51
pubmed: 27489335
Front Pharmacol. 2018 Jan 30;9:37
pubmed: 29441021
Eur J Nutr. 2016 Apr;55(3):1011-20
pubmed: 25939797
Environ Int. 2021 May 11;156:106621
pubmed: 33984575
Environ Int. 2019 Mar;124:249-258
pubmed: 30660025
Occup Environ Med. 2015 May;72(5):373-80
pubmed: 25601914