CYP3A4
CYP3A4∗22
cytochrome P450
genotype-guided dosing
genotyping
personalized medicine
pharmacogenetics
rs35599367
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2021
2021
Historique:
received:
19
05
2021
accepted:
17
06
2021
entrez:
26
7
2021
pubmed:
27
7
2021
medline:
27
7
2021
Statut:
epublish
Résumé
Cytochrome P450 3A4 (CYP3A4) is the most important drug metabolizing enzyme in the liver, responsible for the oxidative metabolism of ∼50% of clinically prescribed drugs. Therefore, genetic variation in
Identifiants
pubmed: 34306041
doi: 10.3389/fgene.2021.711943
pmc: PMC8296839
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
711943Informations de copyright
Copyright © 2021 Mulder, van Eerden, de With, Elens, Hesselink, Matic, Bins, Mathijssen and van Schaik.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Naunyn Schmiedebergs Arch Pharmacol. 1999 Feb;359(2):147-51
pubmed: 10048600
J Clin Psychopharmacol. 2015 Jun;35(3):228-36
pubmed: 25868121
CPT Pharmacometrics Syst Pharmacol. 2014 Feb 12;3:e100
pubmed: 24522145
PLoS One. 2017 Jul 20;12(7):e0180192
pubmed: 28727815
Clin Cancer Res. 2015 Jan 15;21(2):322-8
pubmed: 25398452
Pharmacogenet Genomics. 2018 Feb;28(2):41-48
pubmed: 29256966
Ther Drug Monit. 2013 Oct;35(5):608-16
pubmed: 24052064
Clin Chem. 2013 Dec;59(12):1761-9
pubmed: 23974086
Adv Drug Deliv Rev. 2002 Nov 18;54(10):1271-94
pubmed: 12406645
Drug Metab Rev. 2000 Aug-Nov;32(3-4):339-61
pubmed: 11139133
Drug Metab Dispos. 1990 Jul-Aug;18(4):476-83
pubmed: 1976071
Clin Cancer Res. 2000 Apr;6(4):1255-8
pubmed: 10778948
Pharmacogenomics. 2015;16(6):601-17
pubmed: 25893704
Pharmacogenomics J. 2018 May 22;18(3):422-430
pubmed: 28719598
Pharmacogenomics. 2013 Jul;14(9):1027-36
pubmed: 23837477
Cancer Chemother Pharmacol. 2012 Jan;69(1):125-35
pubmed: 21626050
Clin Pharmacokinet. 2012 Jul 1;51(7):467-80
pubmed: 22624503
Pharmacogenomics. 2014 Jun;15(9):1207-21
pubmed: 25141896
Pharmacogenomics J. 2018 Apr;18(2):232-237
pubmed: 28440343
Clin Pharmacol Ther. 2002 Mar;71(3):196-204
pubmed: 11907494
J Natl Cancer Inst. 1998 Aug 19;90(16):1225-9
pubmed: 9719084
Cell Mol Neurobiol. 1997 Apr;17(2):227-33
pubmed: 9140699
Pharmacogenomics J. 2009 Oct;9(5):319-26
pubmed: 19506580
Biochem Biophys Res Commun. 1999 May 27;259(1):201-5
pubmed: 10334940
Pharmacogenet Genomics. 2011 Dec;21(12):861-6
pubmed: 21946898
Clin Pharmacokinet. 2003;42(9):819-50
pubmed: 12882588
Drug Metab Dispos. 2000 Oct;28(10):1168-75
pubmed: 10997935
Clin Pharmacol Ther. 2013 Aug;94(2):201-2
pubmed: 23588314
Pharmacogenomics J. 2015 Apr;15(2):144-52
pubmed: 25287072
Ther Drug Monit. 2016 Apr;38(2):143-69
pubmed: 26982492
Cancer Res. 1994 Aug 1;54(15):4026-35
pubmed: 7913410
J Antimicrob Chemother. 2019 Jun 1;74(6):1670-1678
pubmed: 30815689
Breast Cancer Res Treat. 2014 Jun;145(2):419-28
pubmed: 24744093
Am J Transplant. 2016 Jul;16(7):2085-96
pubmed: 26714287
Lancet. 2019 Aug 10;394(10197):521-532
pubmed: 31395440
Psychiatry Res. 2020 Aug;290:113017
pubmed: 32485484
Pharmacogenomics. 2018 Nov;19(16):1259-1268
pubmed: 30196760
Ther Drug Monit. 2017 Dec;39(6):589-595
pubmed: 29135906
Pharmacogenet Genomics. 2014 Oct;24(10):486-91
pubmed: 25051018
Cancer Res. 2004 Nov 15;64(22):8461-7
pubmed: 15548719
Pharmacogenet Genomics. 2017 Aug;27(8):307-312
pubmed: 28678138
AAPS J. 2017 Nov 27;20(1):4
pubmed: 29181807
Clin Cancer Res. 2013 Jun 15;19(12):3316-24
pubmed: 23640974
Biomedicines. 2020 Apr 22;8(4):
pubmed: 32331352
Pharmacogenet Genomics. 2012 May;22(5):373-80
pubmed: 22388796
J Pharmacol Exp Ther. 2005 Feb;312(2):583-91
pubmed: 15523003
Drug Metab Dispos. 2001 Aug;29(8):1102-9
pubmed: 11454728
Drug Metab Dispos. 2011 May;39(5):757-62
pubmed: 21266595
Clin Pharmacol Ther. 2021 May;109(5):1244-1255
pubmed: 33047329
Clin Pharmacol Ther. 2014 Jul;96(1):90-100
pubmed: 24598718
Clin Chem. 2000 Nov;46(11):1834-6
pubmed: 11067821
Pharmacogenomics. 2011 Oct;12(10):1383-96
pubmed: 21902502
J Toxicol Sci. 2013;38(3):349-54
pubmed: 23665933
Clin Pharmacol Ther. 2021 Jul;110(1):169-178
pubmed: 33452682
Breast Cancer Res Treat. 2013 May;139(1):95-105
pubmed: 23580071
Clin Pharmacol Ther. 2020 Feb;107(2):462-470
pubmed: 31513279
Br J Clin Pharmacol. 2017 Jun;83(6):1252-1262
pubmed: 28044353
Pharmacogenet Genomics. 2013 Aug;23(8):445-8
pubmed: 23778326
Pharmacogenomics. 2015 Jul;16(8):841-54
pubmed: 26067485
Endocr Relat Cancer. 2014 May 06;21(3):R235-46
pubmed: 24659478
Pharmacogenomics. 2014 Feb;15(2):179-88
pubmed: 24444408
Food Chem Toxicol. 2018 Aug;118:889-907
pubmed: 29960018
Kidney Int. 2010 Dec;78(11):1068-74
pubmed: 20703217
Nat Genet. 2001 Apr;27(4):383-91
pubmed: 11279519
Clin Pharmacol Ther. 2003 Sep;74(3):245-54
pubmed: 12966368
Cancers (Basel). 2021 Feb 12;13(4):
pubmed: 33673305
Pharmacogenet Genomics. 2017 Sep;27(9):313-322
pubmed: 28704257
J Clin Psychiatry. 2002 Sep;63(9):756-7
pubmed: 12363113
Clin Pharmacol Ther. 2012 Jun;91(6):1044-52
pubmed: 22510778
Clin Pharmacol Ther. 2015 Aug;98(2):127-34
pubmed: 25974703
Pharmacogenetics. 1998 Oct;8(5):391-401
pubmed: 9825831
Clin Pharmacol Ther. 2014 Jul;96(1):81-9
pubmed: 24566734
J Clin Psychopharmacol. 2014 Apr;34(2):256-60
pubmed: 24525658
Drug Metab Pers Ther. 2015 Mar;30(1):43-8
pubmed: 25274942
Eur Heart J. 2011 Dec;32(23):2933-44
pubmed: 22090660
Cancer Chemother Pharmacol. 2010 Jul;66(2):357-71
pubmed: 19967539
J Clin Oncol. 2002 Sep 1;20(17):3683-90
pubmed: 12202670
Eur J Clin Pharmacol. 2014 Jun;70(6):685-93
pubmed: 24658827
Eur J Clin Pharmacol. 2016 Feb;72(2):163-74
pubmed: 26521259
Gene. 2020 May 20;739:144513
pubmed: 32112986
Clin Pharmacol Ther. 1999 Sep;66(3):288-94
pubmed: 10511065
Clin Pharmacokinet. 2019 May;58(5):651-658
pubmed: 30367352
Clin Pharmacokinet. 2001;40(7):509-22
pubmed: 11510628
Pharmacogenomics J. 2011 Aug;11(4):274-86
pubmed: 20386561
Transplantation. 2016 Oct;100(10):2129-2137
pubmed: 27653228
J Cardiovasc Pharmacol. 2015 Jul;66(1):80-5
pubmed: 26164721
Curr Drug Metab. 2002 Dec;3(6):561-97
pubmed: 12369887
Drugs R D. 2017 Jun;17(2):279-286
pubmed: 28229376
Expert Opin Drug Metab Toxicol. 2006 Apr;2(2):171-82
pubmed: 16866606
Pharmacogenetics. 2002 Jul;12(5):355-66
pubmed: 12142725
Br J Clin Pharmacol. 2003 Jul;56(1):120-4
pubmed: 12848784
Am J Transplant. 2015 Mar;15(3):800-5
pubmed: 25588704
Clin Ther. 2002 Mar;24(3):330-50; discussion 329
pubmed: 11952020
J Natl Cancer Inst. 1999 Sep 15;91(18):1588-90
pubmed: 10491443
Lancet Oncol. 2018 Nov;19(11):1459-1467
pubmed: 30348537
Pharmacotherapy. 2018 Jul;38(7):e46-e52
pubmed: 29804290
Curr Drug Metab. 2019;20(8):682-694
pubmed: 31385766
Clin Pharmacokinet. 2015 Dec;54(12):1259-72
pubmed: 26129906
Basic Clin Pharmacol Toxicol. 2019 Mar;124(3):321-329
pubmed: 30281924
Am J Transplant. 2014 Dec;14(12):2796-806
pubmed: 25278376
Mol Pharmacol. 2002 Jul;62(1):162-72
pubmed: 12065767
Anesthesiology. 1992 Sep;77(3):467-74
pubmed: 1519785
Clin Pharmacol Ther. 2010 Jun;87(6):721-6
pubmed: 20393454
Br J Cancer. 2014 Nov 11;111(10):1909-16
pubmed: 25349968
Pharmacogenomics J. 2017 Dec;17(6):521-527
pubmed: 27549341
Front Pharmacol. 2020 Sep 11;11:575540
pubmed: 33041820
Clin Exp Nephrol. 2018 Apr;22(2):413-419
pubmed: 28699031
Pharmacogenet Genomics. 2014 Sep;24(9):459-63
pubmed: 24950369
Clin Chem. 2011 Nov;57(11):1574-83
pubmed: 21903774
Clin Pharmacol Ther. 2017 Oct;102(4):688-700
pubmed: 28378927
J Clin Oncol. 2006 Apr 1;24(10):1633-42
pubmed: 16575015
Pharmacogenetics. 1997 Feb;7(1):1-10
pubmed: 9110356
Clin Pharmacol Ther. 2019 Feb;105(2):448-457
pubmed: 29998574
Pharmacogenomics. 2013 Jan;14(2):137-49
pubmed: 23327575
Pharmacogenetics. 2002 Mar;12(2):121-32
pubmed: 11875366
Anesth Analg. 1996 Jan;82(1):167-72
pubmed: 8712396
Pharmacogenet Genomics. 2014 Apr;24(4):185-94
pubmed: 24469018
Clin Pharmacol Ther. 2018 May;103(5):770-777
pubmed: 29385237
Pharmacogenet Genomics. 2016 Jan;26(1):40-3
pubmed: 26488616