Single-step Replacement of an Unreactive C-H Bond by a C-S Bond Using Polysulfide as the Direct Sulfur Source in Anaerobic Ergothioneine Biosynthesis.

C-H bond activation crystal structure ergothioneine biosynthesis polysulfide transsulfuration

Journal

ACS catalysis
ISSN: 2155-5435
Titre abrégé: ACS Catal
Pays: United States
ID NLM: 101562209

Informations de publication

Date de publication:
21 Aug 2020
Historique:
entrez: 26 7 2021
pubmed: 27 7 2021
medline: 27 7 2021
Statut: ppublish

Résumé

Ergothioneine, a natural longevity vitamin and antioxidant, is a thiol-histidine derivative. Recently, two types of biosynthetic pathways were reported. In the aerobic ergothioneine biosynthesis, a non-heme iron enzyme incorporates a sulfoxide to an sp

Identifiants

pubmed: 34306804
doi: 10.1021/acscatal.0c01809
pmc: PMC8302205
mid: NIHMS1642409
doi:

Types de publication

Journal Article

Langues

eng

Pagination

8981-8994

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM106443
Pays : United States
Organisme : NCCIH NIH HHS
ID : R41 AT010878
Pays : United States

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Auteurs

Ronghai Cheng (R)

Department of Chemistry, Boston University, Boston, MA 02215, USA.

Lian Wu (L)

State Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Shanghai 200032, China.
Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Shanghai 200032, China.
College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.

Rui Lai (R)

Department of Chemistry, Boston University, Boston, MA 02215, USA.

Chao Peng (C)

National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Science, Shanghai 201210, China.

Nathchar Naowarojna (N)

Department of Chemistry, Boston University, Boston, MA 02215, USA.

Weiyao Hu (W)

Department of Chemistry, Boston University, Boston, MA 02215, USA.
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.

Xinhao Li (X)

School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.

Stephen A Whelan (SA)

Department of Chemistry, Boston University, Boston, MA 02215, USA.

Norman Lee (N)

Department of Chemistry, Boston University, Boston, MA 02215, USA.

Juan Lopez (J)

Department of Chemistry, Boston University, Boston, MA 02215, USA.

Changming Zhao (C)

Department of Chemistry, Boston University, Boston, MA 02215, USA.
Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Hubei 430072, People's Republic of China.

Youhua Yong (Y)

State Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Shanghai 200032, China.

Jiahui Xue (J)

Shanghai Key Laboratory of Green Chemistry and Chemical Process, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, P. R. China.

Xuefeng Jiang (X)

Shanghai Key Laboratory of Green Chemistry and Chemical Process, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, P. R. China.

Mark W Grinstaff (MW)

Department of Chemistry, Boston University, Boston, MA 02215, USA.
Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.

Zixin Deng (Z)

Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Hubei 430072, People's Republic of China.

Jiesheng Chen (J)

School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.

Qiang Cui (Q)

Department of Chemistry, Boston University, Boston, MA 02215, USA.

Jiahai Zhou (J)

State Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Shanghai 200032, China.

Pinghua Liu (P)

Department of Chemistry, Boston University, Boston, MA 02215, USA.

Classifications MeSH