Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration.
Wnt‐/Hedgehog‐signaling
functional shRNA screen
regeneration
reprogramming
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
15
02
2021
entrez:
26
7
2021
pubmed:
27
7
2021
medline:
4
1
2022
Statut:
epublish
Résumé
Somatic cell reprogramming and tissue repair share relevant factors and molecular programs. Here, Dickkopf-3 (DKK3) is identified as novel factor for organ regeneration using combined transcription-factor-induced reprogramming and RNA-interference techniques. Loss of
Identifiants
pubmed: 34306986
doi: 10.1002/advs.202100626
pii: ADVS2574
pmc: PMC8292873
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Dkk3 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2100626Informations de copyright
© 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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