Identification of Predictive Biomarkers for Lymph Node Involvement in Obese Women With Endometrial Cancer.
body mass index (BMI)
endometrial cancer
lymph node
molecular markers
obesity
tumor biomarkers
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2021
2021
Historique:
received:
14
04
2021
accepted:
23
06
2021
entrez:
26
7
2021
pubmed:
27
7
2021
medline:
27
7
2021
Statut:
epublish
Résumé
Obesity, an established risk factor for endometrial cancer (EC), is also associated to increased risks of intraoperative and postoperative complications. A reliable tool to identify patients at low risk for lymph node (LN) metastasis may allow minimizing the surgical staging and omit lymphadenectomy in obese patients. To identify molecular biomarkers that could predict LN involvement in obese patients with EC we performed gene expression analysis in 549 EC patients using publicly available transcriptomic datasets. Patients were filtrated according to cancer subtype, weight (>30 kg/m
Identifiants
pubmed: 34307159
doi: 10.3389/fonc.2021.695404
pmc: PMC8292832
doi:
Types de publication
Journal Article
Langues
eng
Pagination
695404Informations de copyright
Copyright © 2021 López-Ozuna, Kogan, Hachim, Matanes, Hachim, Mitric, Kiow, Lau, Salvador, Yasmeen and Gotlieb.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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