Stem Cell Therapies for Progressive Multiple Sclerosis.
clinical trial
mesenchymal stem cell
neural stem cell
progressive multiple sclerosis
regenerative neuroimmunology
stem cell therapy
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
04
2021
accepted:
10
06
2021
entrez:
26
7
2021
pubmed:
27
7
2021
medline:
27
7
2021
Statut:
epublish
Résumé
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination and axonal degeneration. MS patients typically present with a relapsing-remitting (RR) disease course, manifesting as sporadic attacks of neurological symptoms including ataxia, fatigue, and sensory impairment. While there are several effective disease-modifying therapies able to address the inflammatory relapses associated with RRMS, most patients will inevitably advance to a progressive disease course marked by a gradual and irreversible accrual of disabilities. Therapeutic intervention in progressive MS (PMS) suffers from a lack of well-characterized biological targets and, hence, a dearth of successful drugs. The few medications approved for the treatment of PMS are typically limited in their efficacy to
Identifiants
pubmed: 34307372
doi: 10.3389/fcell.2021.696434
pmc: PMC8299560
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
696434Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Smith, Nicaise, Ionescu, Hamel, Peruzzotti-Jametti and Pluchino.
Déclaration de conflit d'intérêts
SP is co-founder, CSO and shareholder (>5%) of CITC Ltd. and iSTEM Therapeutics, and co-founder and Non-Executive Director at Asitia Therapeutics. LP-J is shareholder of CITC Ltd. JAS is an employee of CITC Ltd. and Head of Research at iSTEM Tx. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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